The circle of life:Phases of podosome formation, turnover and reemergence

Kathrin Weber; Sven Hey; Pasquale Cervero; Stefan Linder

doi:10.1016/j.ejcb.2022.151218

The circle of life:Phases of podosome formation, turnover and reemergence

Standard

The circle of life:Phases of podosome formation, turnover and reemergence. / Weber, Kathrin; Hey, Sven ; Cervero, Pasquale ; Linder, Stefan.

In: EUR J CELL BIOL, Vol. 101, No. 2, 151218, 04.2022.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Weber, K, Hey, S , Cervero, P & Linder, S 2022, 'The circle of life:Phases of podosome formation, turnover and reemergence', EUR J CELL BIOL, vol. 101, no. 2, 151218. https://doi.org/10.1016/j.ejcb.2022.151218

APA

Weber, K., Hey, S., Cervero, P., & Linder, S. (2022). The circle of life:Phases of podosome formation, turnover and reemergence. EUR J CELL BIOL, 101(2), [151218]. https://doi.org/10.1016/j.ejcb.2022.151218

Vancouver

Weber K, Hey S , Cervero P , Linder S. The circle of life:Phases of podosome formation, turnover and reemergence. EUR J CELL BIOL. 2022 Apr;101(2). 151218. https://doi.org/10.1016/j.ejcb.2022.151218

Bibtex

@article{97d8e63b36d74d67936b2db319697e46,

title = "The circle of life:Phases of podosome formation, turnover and reemergence",

abstract = "Podosomes are highly dynamic actin-rich structures in a variety of cell types, especially monocytic cells. They fulfill multiple functions such as adhesion, mechanosensing, or extracellular matrix degradation, thus allowing cells to detect and respond to a changing environment. These abilities are based on an intricate architecture that enables podosomes to sense mechanical properties of their substratum and to transduce them intracellularly in order to generate an appropriate cellular response. These processes are enabled through the tightly orchestrated interplay of more than 300 different components that are dynamically recruited during podosome formation and turnover. In this review, we discuss the different phases of the podosome life cycle and the current knowledge on regulatory factors that impact on the genesis, activity, dissolution and reemergence of podosomes. We also highlight mechanoregulatory processes that become important during these different stages, on the level of individual podosomes, and also at podosome sub- and superstructures.",

keywords = "Actins/metabolism, Podosomes/metabolism",

author = "Kathrin Weber and Sven Hey and Pasquale Cervero and Stefan Linder",

year = "2022",

month = apr,

doi = "10.1016/j.ejcb.2022.151218",

language = "English",

volume = "101",

journal = "EUR J CELL BIOL",

issn = "0171-9335",

publisher = "Urban und Fischer Verlag GmbH und Co. KG",

number = "2",

}

RIS

TY - JOUR

T1 - The circle of life:Phases of podosome formation, turnover and reemergence

AU - Weber, Kathrin

AU - Hey, Sven

AU - Cervero, Pasquale

AU - Linder, Stefan

PY - 2022/4

Y1 - 2022/4

N2 - Podosomes are highly dynamic actin-rich structures in a variety of cell types, especially monocytic cells. They fulfill multiple functions such as adhesion, mechanosensing, or extracellular matrix degradation, thus allowing cells to detect and respond to a changing environment. These abilities are based on an intricate architecture that enables podosomes to sense mechanical properties of their substratum and to transduce them intracellularly in order to generate an appropriate cellular response. These processes are enabled through the tightly orchestrated interplay of more than 300 different components that are dynamically recruited during podosome formation and turnover. In this review, we discuss the different phases of the podosome life cycle and the current knowledge on regulatory factors that impact on the genesis, activity, dissolution and reemergence of podosomes. We also highlight mechanoregulatory processes that become important during these different stages, on the level of individual podosomes, and also at podosome sub- and superstructures.

AB - Podosomes are highly dynamic actin-rich structures in a variety of cell types, especially monocytic cells. They fulfill multiple functions such as adhesion, mechanosensing, or extracellular matrix degradation, thus allowing cells to detect and respond to a changing environment. These abilities are based on an intricate architecture that enables podosomes to sense mechanical properties of their substratum and to transduce them intracellularly in order to generate an appropriate cellular response. These processes are enabled through the tightly orchestrated interplay of more than 300 different components that are dynamically recruited during podosome formation and turnover. In this review, we discuss the different phases of the podosome life cycle and the current knowledge on regulatory factors that impact on the genesis, activity, dissolution and reemergence of podosomes. We also highlight mechanoregulatory processes that become important during these different stages, on the level of individual podosomes, and also at podosome sub- and superstructures.

KW - Actins/metabolism

KW - Podosomes/metabolism

U2 - 10.1016/j.ejcb.2022.151218

DO - 10.1016/j.ejcb.2022.151218

M3 - SCORING: Review article

C2 - 35334303

VL - 101

JO - EUR J CELL BIOL

JF - EUR J CELL BIOL

SN - 0171-9335

IS - 2

M1 - 151218

ER -