The circle of life:Phases of podosome formation, turnover and reemergence
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The circle of life:Phases of podosome formation, turnover and reemergence. / Weber, Kathrin; Hey, Sven; Cervero, Pasquale; Linder, Stefan.
in: EUR J CELL BIOL, Jahrgang 101, Nr. 2, 151218, 04.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - The circle of life:Phases of podosome formation, turnover and reemergence
AU - Weber, Kathrin
AU - Hey, Sven
AU - Cervero, Pasquale
AU - Linder, Stefan
N1 - Copyright © 2022 The Authors. Published by Elsevier GmbH.. All rights reserved.
PY - 2022/4
Y1 - 2022/4
N2 - Podosomes are highly dynamic actin-rich structures in a variety of cell types, especially monocytic cells. They fulfill multiple functions such as adhesion, mechanosensing, or extracellular matrix degradation, thus allowing cells to detect and respond to a changing environment. These abilities are based on an intricate architecture that enables podosomes to sense mechanical properties of their substratum and to transduce them intracellularly in order to generate an appropriate cellular response. These processes are enabled through the tightly orchestrated interplay of more than 300 different components that are dynamically recruited during podosome formation and turnover. In this review, we discuss the different phases of the podosome life cycle and the current knowledge on regulatory factors that impact on the genesis, activity, dissolution and reemergence of podosomes. We also highlight mechanoregulatory processes that become important during these different stages, on the level of individual podosomes, and also at podosome sub- and superstructures.
AB - Podosomes are highly dynamic actin-rich structures in a variety of cell types, especially monocytic cells. They fulfill multiple functions such as adhesion, mechanosensing, or extracellular matrix degradation, thus allowing cells to detect and respond to a changing environment. These abilities are based on an intricate architecture that enables podosomes to sense mechanical properties of their substratum and to transduce them intracellularly in order to generate an appropriate cellular response. These processes are enabled through the tightly orchestrated interplay of more than 300 different components that are dynamically recruited during podosome formation and turnover. In this review, we discuss the different phases of the podosome life cycle and the current knowledge on regulatory factors that impact on the genesis, activity, dissolution and reemergence of podosomes. We also highlight mechanoregulatory processes that become important during these different stages, on the level of individual podosomes, and also at podosome sub- and superstructures.
KW - Actins/metabolism
KW - Podosomes/metabolism
U2 - 10.1016/j.ejcb.2022.151218
DO - 10.1016/j.ejcb.2022.151218
M3 - SCORING: Review article
C2 - 35334303
VL - 101
JO - EUR J CELL BIOL
JF - EUR J CELL BIOL
SN - 0171-9335
IS - 2
M1 - 151218
ER -