Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk

Thi Thanh Truc Nguyen; Robin Kobbe; Ulf Schulze-Sturm; Martin Blohm; Bettina Hollwitz; Sandra Hertling; Christina Becker; Prasad Thomas Oommen; Hans-Jürgen Laws; Franca Martignoni; Björn-Erik Ole Jensen; Karen Olah; Susanne Schmidtke; Benno Kreuels; Malte Kohns Vasconcelos; Jennifer Neubert

doi:10.1097/INF.0000000000002357

Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk

Thi Thanh Truc Nguyen
Robin Kobbe
Ulf Schulze-Sturm
Martin Blohm
Bettina Hollwitz
Sandra Hertling
Christina Becker
Prasad Thomas Oommen
Hans-Jürgen Laws
Franca Martignoni
Björn-Erik Ole Jensen
Karen Olah
Susanne Schmidtke
Benno Kreuels
Malte Kohns Vasconcelos
Jennifer Neubert

Related Research units

Department of Pediatrics
Department of Obstetrics and Fetal Medicine
I. Medical Clinic and Polyclinic

Abstract

Using retrospectively collected data from 383 infants born to HIV-1-infected mothers receiving antiretroviral therapy, we compared transmission rates and hematologic toxicity between infants receiving 2-week (short course) versus longer duration zidovudine postexposure prophylaxis. Short course resulted in lower hematologic toxicity without evidence of increased vertical transmission risk.

Bibliographical data

Original language	English
ISSN	0891-3668
DOIs	https://doi.org/10.1097/INF.0000000000002357
Publication status	Published - 07.2019

PubMed	31033907