Prevalence of key resistance mutations K65R, K103N, and M184V as minority HIV-1 variants in chronically HIV-1 infected, treatment-naïve patients.

  • Karin J Metzner
  • Pia Rauch
  • Patrick Braun
  • Heribert Knechten
  • Robert Ehret
  • Klaus Korn
  • Rolf Kaiser
  • Nadine Sichtig
  • Britta Ranneberg
  • Jan van Lunzen
  • Hauke Walter

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Abstract

Minority drug-resistant HIV-1 variants, undetected by conventional genotyping, may impair the outcome of antiretroviral therapy (ART). Thus, we retrospectively analyzed the prevalence of minority drug-resistant HIV-1 variants before ART in chronically HIV-1 infected patients initiating first-line therapy and assessed the impact on clinical outcome in the prospective German Truvada cohort.

Bibliographical data

Original languageGerman
Article number2
ISSN1386-6532
Publication statusPublished - 2011
pubmed 21056001