Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentation.

  • Thomas Karn
  • Lajos Pusztai
  • Eugen Ruckhäberle
  • Cornelia Liedtke
  • Volkmar Müller
  • Marcus Schmidt
  • Dirk Metzler
  • Jing Wang
  • Kevin R Coombes
  • Regine Gätje
  • Lars Hanker
  • Christine Solbach
  • Andre Ahr
  • Uwe Holtrich
  • Achim Rody
  • Manfred Kaufmann

Related Research units

Abstract

Molecular markers displaying bimodal expression distribution can reveal distinct disease subsets and may serve as prognostic or predictive markers or represent therapeutic targets. Oestrogen (ER) and human epidermal growth factor receptor 2 (HER2) receptors are strongly bimodally expressed genes in breast cancer.

Bibliographical data

Original languageEnglish
Article number1
ISSN0959-8049
Publication statusPublished - 2012
pubmed 21741824