Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentation.

  • Thomas Karn
  • Lajos Pusztai
  • Eugen Ruckhäberle
  • Cornelia Liedtke
  • Volkmar Müller
  • Marcus Schmidt
  • Dirk Metzler
  • Jing Wang
  • Kevin R Coombes
  • Regine Gätje
  • Lars Hanker
  • Christine Solbach
  • Andre Ahr
  • Uwe Holtrich
  • Achim Rody
  • Manfred Kaufmann

Beteiligte Einrichtungen

Abstract

Molecular markers displaying bimodal expression distribution can reveal distinct disease subsets and may serve as prognostic or predictive markers or represent therapeutic targets. Oestrogen (ER) and human epidermal growth factor receptor 2 (HER2) receptors are strongly bimodally expressed genes in breast cancer.

Bibliografische Daten

OriginalspracheEnglisch
Aufsatznummer1
ISSN0959-8049
StatusVeröffentlicht - 2012
pubmed 21741824