Matrix metalloproteinases at a glance
Standard
Matrix metalloproteinases at a glance. / Hey, Sven; Linder, Stefan.
In: J CELL SCI, Vol. 137, No. 2, cs261898, 15.01.2024.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Matrix metalloproteinases at a glance
AU - Hey, Sven
AU - Linder, Stefan
N1 - © 2024. Published by The Company of Biologists Ltd.
PY - 2024/1/15
Y1 - 2024/1/15
N2 - Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that belong to the group of endopeptidases or matrixins. They are able to cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. Accordingly, MMPs play key roles in a variety of physiological and pathological processes, such as tissue homeostasis and cancer cell invasion. MMP activity is exquisitely regulated at several levels, including pro-domain removal, association with inhibitors, intracellular trafficking and transport via extracellular vesicles. Moreover, the regulation of MMP activity is currently being rediscovered for the development of respective therapies for the treatment of cancer, as well as infectious, inflammatory and neurological diseases. In this Cell Science at a Glance article and the accompanying poster, we present an overview of the current knowledge regarding the regulation of MMP activity, the intra- and extra-cellular trafficking pathways of these enzymes and their diverse groups of target proteins, as well as their impact on health and disease.
AB - Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that belong to the group of endopeptidases or matrixins. They are able to cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. Accordingly, MMPs play key roles in a variety of physiological and pathological processes, such as tissue homeostasis and cancer cell invasion. MMP activity is exquisitely regulated at several levels, including pro-domain removal, association with inhibitors, intracellular trafficking and transport via extracellular vesicles. Moreover, the regulation of MMP activity is currently being rediscovered for the development of respective therapies for the treatment of cancer, as well as infectious, inflammatory and neurological diseases. In this Cell Science at a Glance article and the accompanying poster, we present an overview of the current knowledge regarding the regulation of MMP activity, the intra- and extra-cellular trafficking pathways of these enzymes and their diverse groups of target proteins, as well as their impact on health and disease.
KW - Endopeptidases
KW - Extracellular Matrix
KW - Extracellular Vesicles
KW - Membrane Proteins
KW - Matrix Metalloproteinases
U2 - 10.1242/jcs.261898
DO - 10.1242/jcs.261898
M3 - SCORING: Review article
C2 - 38236162
VL - 137
JO - J CELL SCI
JF - J CELL SCI
SN - 0021-9533
IS - 2
M1 - cs261898
ER -