Matrix metalloproteinases at a glance

Sven Hey; Stefan Linder

doi:10.1242/jcs.261898

Matrix metalloproteinases at a glance

Standard

Matrix metalloproteinases at a glance. / Hey, Sven ; Linder, Stefan.

in: J CELL SCI, Jahrgang 137, Nr. 2, cs261898, 15.01.2024.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Hey, S & Linder, S 2024, 'Matrix metalloproteinases at a glance', J CELL SCI, Jg. 137, Nr. 2, cs261898. https://doi.org/10.1242/jcs.261898

APA

Hey, S., & Linder, S. (2024). Matrix metalloproteinases at a glance. J CELL SCI, 137(2), [cs261898]. https://doi.org/10.1242/jcs.261898

Vancouver

Hey S , Linder S. Matrix metalloproteinases at a glance. J CELL SCI. 2024 Jan 15;137(2). cs261898. https://doi.org/10.1242/jcs.261898

Bibtex

@article{92bb3a4cc6e24b6b8a0d323029851714,

title = "Matrix metalloproteinases at a glance",

abstract = "Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that belong to the group of endopeptidases or matrixins. They are able to cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. Accordingly, MMPs play key roles in a variety of physiological and pathological processes, such as tissue homeostasis and cancer cell invasion. MMP activity is exquisitely regulated at several levels, including pro-domain removal, association with inhibitors, intracellular trafficking and transport via extracellular vesicles. Moreover, the regulation of MMP activity is currently being rediscovered for the development of respective therapies for the treatment of cancer, as well as infectious, inflammatory and neurological diseases. In this Cell Science at a Glance article and the accompanying poster, we present an overview of the current knowledge regarding the regulation of MMP activity, the intra- and extra-cellular trafficking pathways of these enzymes and their diverse groups of target proteins, as well as their impact on health and disease.",

keywords = "Endopeptidases, Extracellular Matrix, Extracellular Vesicles, Membrane Proteins, Matrix Metalloproteinases",

author = "Sven Hey and Stefan Linder",

note = "{\textcopyright} 2024. Published by The Company of Biologists Ltd.",

year = "2024",

month = jan,

day = "15",

doi = "10.1242/jcs.261898",

language = "English",

volume = "137",

journal = "J CELL SCI",

issn = "0021-9533",

publisher = "Company of Biologists Ltd",

number = "2",

}

RIS

TY - JOUR

T1 - Matrix metalloproteinases at a glance

AU - Hey, Sven

AU - Linder, Stefan

PY - 2024/1/15

Y1 - 2024/1/15

N2 - Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that belong to the group of endopeptidases or matrixins. They are able to cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. Accordingly, MMPs play key roles in a variety of physiological and pathological processes, such as tissue homeostasis and cancer cell invasion. MMP activity is exquisitely regulated at several levels, including pro-domain removal, association with inhibitors, intracellular trafficking and transport via extracellular vesicles. Moreover, the regulation of MMP activity is currently being rediscovered for the development of respective therapies for the treatment of cancer, as well as infectious, inflammatory and neurological diseases. In this Cell Science at a Glance article and the accompanying poster, we present an overview of the current knowledge regarding the regulation of MMP activity, the intra- and extra-cellular trafficking pathways of these enzymes and their diverse groups of target proteins, as well as their impact on health and disease.

AB - Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that belong to the group of endopeptidases or matrixins. They are able to cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. Accordingly, MMPs play key roles in a variety of physiological and pathological processes, such as tissue homeostasis and cancer cell invasion. MMP activity is exquisitely regulated at several levels, including pro-domain removal, association with inhibitors, intracellular trafficking and transport via extracellular vesicles. Moreover, the regulation of MMP activity is currently being rediscovered for the development of respective therapies for the treatment of cancer, as well as infectious, inflammatory and neurological diseases. In this Cell Science at a Glance article and the accompanying poster, we present an overview of the current knowledge regarding the regulation of MMP activity, the intra- and extra-cellular trafficking pathways of these enzymes and their diverse groups of target proteins, as well as their impact on health and disease.

KW - Endopeptidases

KW - Extracellular Matrix

KW - Extracellular Vesicles

KW - Membrane Proteins

KW - Matrix Metalloproteinases

U2 - 10.1242/jcs.261898

DO - 10.1242/jcs.261898

M3 - SCORING: Review article

C2 - 38236162

VL - 137

JO - J CELL SCI

JF - J CELL SCI

SN - 0021-9533

IS - 2

M1 - cs261898

ER -