Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability
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Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability. / Mognato, Maddalena; Burdak-Rothkamm, Susanne; Rothkamm, Kai.
In: MUTAT RES-REV MUTAT, Vol. 787, 108346, 05.06.2021.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability
AU - Mognato, Maddalena
AU - Burdak-Rothkamm, Susanne
AU - Rothkamm, Kai
N1 - Copyright © 2020 Elsevier B.V. All rights reserved.
PY - 2021/6/5
Y1 - 2021/6/5
N2 - DNA replication stress is a major source of DNA damage, including double-stranded breaks that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can affect genome integrity. During DNA replication different factors act on chromatin remodeling in a coordinated way. While recent studies have highlighted individual molecular mechanisms of interaction, less is known about the orchestration of chromatin changes under replication stress. In this review we attempt to explore the complex relationship between DNA replication stress, DDR and genome integrity in mammalian cells, taking into account the role of chromatin disposition as an important modulator of DNA repair. Recent data on chromatin restoration and epigenetic re-establishment after DNA replication stress are reviewed.
AB - DNA replication stress is a major source of DNA damage, including double-stranded breaks that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can affect genome integrity. During DNA replication different factors act on chromatin remodeling in a coordinated way. While recent studies have highlighted individual molecular mechanisms of interaction, less is known about the orchestration of chromatin changes under replication stress. In this review we attempt to explore the complex relationship between DNA replication stress, DDR and genome integrity in mammalian cells, taking into account the role of chromatin disposition as an important modulator of DNA repair. Recent data on chromatin restoration and epigenetic re-establishment after DNA replication stress are reviewed.
KW - Animals
KW - Chromatin/metabolism
KW - Chromatin Assembly and Disassembly/genetics
KW - DNA Damage/genetics
KW - DNA Replication/genetics
KW - Genomic Instability/genetics
KW - Humans
U2 - 10.1016/j.mrrev.2020.108346
DO - 10.1016/j.mrrev.2020.108346
M3 - SCORING: Review article
C2 - 34083038
VL - 787
JO - MUTAT RES-REV MUTAT
JF - MUTAT RES-REV MUTAT
SN - 1383-5742
M1 - 108346
ER -