Research ExplorerScientific StaffKai Rothkamm

Prof. Dr. ID: 2375364

Kai Rothkamm

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ORCID: 0000-0001-7414-5729
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Research Interests

  • DNA double-strand break repair: mechanisms and regulation

  • Biomarkers of radiation exposure and effect

  • Strategies for molecular-targeted tumor radiosensitization, based on tumor-specific deficiencies in the DNA damage response.
  • Deputy Director (Science) of the University Cancer Center Hamburg (UCCH)

Publications

Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

The prognostic impact of B7-H3 and B7-H4 in head and neck squamous cell carcinoma

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Preclinical patient-derived modeling of castration-resistant prostate cancer facilitates individualized assessment of homologous recombination repair deficient disease

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Src family kinase targeting in head and neck tumor cells using SU6656, PP2 and dasatinib

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Partial Reduction in BRCA1 Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Tissue Microarray Analyses Suggest Axl as a Predictive Biomarker in HPV-Negative Head and Neck Cancer

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Increased replication stress and R-loop accumulation in EGFRvIII expressing glioblastoma present new therapeutic opportunities

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Patient derived ex vivo tissue slice cultures demonstrate a profound DNA double-strand break repair defect in HPV-positive oropharyngeal head and neck cancer

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Efficient DNA repair mitigates replication stress resulting in less immunogenic cytosolic DNA in radioresistant breast cancer stem cells

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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projects

Stipendium DAAD

Project: Research

195, PSMA

Project: Research

Stiftungen und Vereine < 20.000

Project: Research

02NUK032 DNA-Doppelstrangbruchreparatur

Project: Research

02NUK035B DNA-Reparaturfoci

Project: Research

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