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Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability

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Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability. / Mognato, Maddalena; Burdak-Rothkamm, Susanne; Rothkamm, Kai.

in: MUTAT RES-REV MUTAT, Jahrgang 787, 108346, 05.06.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Mognato, M, Burdak-Rothkamm, S & Rothkamm, K 2021, 'Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability', MUTAT RES-REV MUTAT, Jg. 787, 108346. https://doi.org/10.1016/j.mrrev.2020.108346

APA

Mognato, M., Burdak-Rothkamm, S., & Rothkamm, K. (2021). Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability. MUTAT RES-REV MUTAT, 787, [108346]. https://doi.org/10.1016/j.mrrev.2020.108346

Vancouver

Mognato M, Burdak-Rothkamm S, Rothkamm K. Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability. MUTAT RES-REV MUTAT. 2021 Jun 5;787. 108346. https://doi.org/10.1016/j.mrrev.2020.108346

Bibtex

@article{77d50e61b1a24486aaa57c65a37b45a5,
title = "Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability",
abstract = "DNA replication stress is a major source of DNA damage, including double-stranded breaks that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can affect genome integrity. During DNA replication different factors act on chromatin remodeling in a coordinated way. While recent studies have highlighted individual molecular mechanisms of interaction, less is known about the orchestration of chromatin changes under replication stress. In this review we attempt to explore the complex relationship between DNA replication stress, DDR and genome integrity in mammalian cells, taking into account the role of chromatin disposition as an important modulator of DNA repair. Recent data on chromatin restoration and epigenetic re-establishment after DNA replication stress are reviewed.",
keywords = "Animals, Chromatin/metabolism, Chromatin Assembly and Disassembly/genetics, DNA Damage/genetics, DNA Replication/genetics, Genomic Instability/genetics, Humans",
author = "Maddalena Mognato and Susanne Burdak-Rothkamm and Kai Rothkamm",
note = "Copyright {\textcopyright} 2020 Elsevier B.V. All rights reserved.",
year = "2021",
month = jun,
day = "5",
doi = "10.1016/j.mrrev.2020.108346",
language = "English",
volume = "787",
journal = "MUTAT RES-REV MUTAT",
issn = "1383-5742",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability

AU - Mognato, Maddalena

AU - Burdak-Rothkamm, Susanne

AU - Rothkamm, Kai

N1 - Copyright © 2020 Elsevier B.V. All rights reserved.

PY - 2021/6/5

Y1 - 2021/6/5

N2 - DNA replication stress is a major source of DNA damage, including double-stranded breaks that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can affect genome integrity. During DNA replication different factors act on chromatin remodeling in a coordinated way. While recent studies have highlighted individual molecular mechanisms of interaction, less is known about the orchestration of chromatin changes under replication stress. In this review we attempt to explore the complex relationship between DNA replication stress, DDR and genome integrity in mammalian cells, taking into account the role of chromatin disposition as an important modulator of DNA repair. Recent data on chromatin restoration and epigenetic re-establishment after DNA replication stress are reviewed.

AB - DNA replication stress is a major source of DNA damage, including double-stranded breaks that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can affect genome integrity. During DNA replication different factors act on chromatin remodeling in a coordinated way. While recent studies have highlighted individual molecular mechanisms of interaction, less is known about the orchestration of chromatin changes under replication stress. In this review we attempt to explore the complex relationship between DNA replication stress, DDR and genome integrity in mammalian cells, taking into account the role of chromatin disposition as an important modulator of DNA repair. Recent data on chromatin restoration and epigenetic re-establishment after DNA replication stress are reviewed.

KW - Animals

KW - Chromatin/metabolism

KW - Chromatin Assembly and Disassembly/genetics

KW - DNA Damage/genetics

KW - DNA Replication/genetics

KW - Genomic Instability/genetics

KW - Humans

U2 - 10.1016/j.mrrev.2020.108346

DO - 10.1016/j.mrrev.2020.108346

M3 - SCORING: Review article

C2 - 34083038

VL - 787

JO - MUTAT RES-REV MUTAT

JF - MUTAT RES-REV MUTAT

SN - 1383-5742

M1 - 108346

ER -