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High-sensitivity cardiac troponin I in the general population--defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study

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High-sensitivity cardiac troponin I in the general population--defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study. / Zeller, Tanja; Ojeda, Francisco; Brunner, Fabian J; Peitsmeyer, Philipp; Münzel, Thomas; Binder, Harald; Pfeiffer, Norbert; Michal, Matthias; Wild, Philipp S; Blankenberg, Stefan; Lackner, Karl J.

In: CLIN CHEM LAB MED, Vol. 53, No. 5, 04.2015, p. 699-706.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zeller, T, Ojeda, F, Brunner, FJ, Peitsmeyer, P, Münzel, T, Binder, H, Pfeiffer, N, Michal, M, Wild, PS, Blankenberg, S & Lackner, KJ 2015, 'High-sensitivity cardiac troponin I in the general population--defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study', CLIN CHEM LAB MED, vol. 53, no. 5, pp. 699-706. https://doi.org/10.1515/cclm-2014-0619

APA

Zeller, T., Ojeda, F., Brunner, F. J., Peitsmeyer, P., Münzel, T., Binder, H., Pfeiffer, N., Michal, M., Wild, P. S., Blankenberg, S., & Lackner, K. J. (2015). High-sensitivity cardiac troponin I in the general population--defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study. CLIN CHEM LAB MED, 53(5), 699-706. https://doi.org/10.1515/cclm-2014-0619

Vancouver

Zeller T, Ojeda F, Brunner FJ, Peitsmeyer P, Münzel T, Binder H et al. High-sensitivity cardiac troponin I in the general population--defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study. CLIN CHEM LAB MED. 2015 Apr;53(5):699-706. https://doi.org/10.1515/cclm-2014-0619

Bibtex

@article{5ac114c4a05d4bfd8049c8e5fcd3f27f,
title = "High-sensitivity cardiac troponin I in the general population--defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study",
abstract = "BACKGROUND: The 99th percentile of cardiac troponin levels, determined in a reference population, is accepted as threshold for diagnosis of acute myocardial infarction (AMI). However, there is no common consensus of how to define the reference population. The aim of the present study was to determine 99th percentile reference values, determined by a high-sensitivity assay (hsTnI), according to different health status and cardiovascular risk factor prevalence in a large population-based sample.METHODS: Troponin I was determined using the Abbott ARCHITECT STAT highly sensitive troponin I immunoassay in 4138 participants of the Gutenberg Health Study.RESULTS: hsTnI was detectable in 81.6% of all individuals. The 99th percentile of the overall population was 27 ng/L. Age and gender had a prominent influence on these values. Exclusion of individuals with elevated natriuretic peptide levels or cardiac abnormalities resulted in lower 99th percentile values, whereas exclusion of individuals with an impaired estimated glomerular filtration rate (eGFR) or with prevalent coronary artery disease/myocardial infarction (CAD/MI) did not result in a meaningful change.CONCLUSIONS: Troponin I, measured by a high-sensitivity assay, can be reliably detected in the vast majority of the general population. hsTnI values were dependent on age, gender as well as structural and functional cardiac abnormalities.",
keywords = "Blood Chemical Analysis/standards, Europe, Female, Health Status, Humans, Limit of Detection, Male, Middle Aged, Myocardium/metabolism, Public Health, Reference Values, Troponin I/blood",
author = "Tanja Zeller and Francisco Ojeda and Brunner, {Fabian J} and Philipp Peitsmeyer and Thomas M{\"u}nzel and Harald Binder and Norbert Pfeiffer and Matthias Michal and Wild, {Philipp S} and Stefan Blankenberg and Lackner, {Karl J}",
year = "2015",
month = apr,
doi = "10.1515/cclm-2014-0619",
language = "English",
volume = "53",
pages = "699--706",
journal = "CLIN CHEM LAB MED",
issn = "1434-6621",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "5",

}

RIS

TY - JOUR

T1 - High-sensitivity cardiac troponin I in the general population--defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study

AU - Zeller, Tanja

AU - Ojeda, Francisco

AU - Brunner, Fabian J

AU - Peitsmeyer, Philipp

AU - Münzel, Thomas

AU - Binder, Harald

AU - Pfeiffer, Norbert

AU - Michal, Matthias

AU - Wild, Philipp S

AU - Blankenberg, Stefan

AU - Lackner, Karl J

PY - 2015/4

Y1 - 2015/4

N2 - BACKGROUND: The 99th percentile of cardiac troponin levels, determined in a reference population, is accepted as threshold for diagnosis of acute myocardial infarction (AMI). However, there is no common consensus of how to define the reference population. The aim of the present study was to determine 99th percentile reference values, determined by a high-sensitivity assay (hsTnI), according to different health status and cardiovascular risk factor prevalence in a large population-based sample.METHODS: Troponin I was determined using the Abbott ARCHITECT STAT highly sensitive troponin I immunoassay in 4138 participants of the Gutenberg Health Study.RESULTS: hsTnI was detectable in 81.6% of all individuals. The 99th percentile of the overall population was 27 ng/L. Age and gender had a prominent influence on these values. Exclusion of individuals with elevated natriuretic peptide levels or cardiac abnormalities resulted in lower 99th percentile values, whereas exclusion of individuals with an impaired estimated glomerular filtration rate (eGFR) or with prevalent coronary artery disease/myocardial infarction (CAD/MI) did not result in a meaningful change.CONCLUSIONS: Troponin I, measured by a high-sensitivity assay, can be reliably detected in the vast majority of the general population. hsTnI values were dependent on age, gender as well as structural and functional cardiac abnormalities.

AB - BACKGROUND: The 99th percentile of cardiac troponin levels, determined in a reference population, is accepted as threshold for diagnosis of acute myocardial infarction (AMI). However, there is no common consensus of how to define the reference population. The aim of the present study was to determine 99th percentile reference values, determined by a high-sensitivity assay (hsTnI), according to different health status and cardiovascular risk factor prevalence in a large population-based sample.METHODS: Troponin I was determined using the Abbott ARCHITECT STAT highly sensitive troponin I immunoassay in 4138 participants of the Gutenberg Health Study.RESULTS: hsTnI was detectable in 81.6% of all individuals. The 99th percentile of the overall population was 27 ng/L. Age and gender had a prominent influence on these values. Exclusion of individuals with elevated natriuretic peptide levels or cardiac abnormalities resulted in lower 99th percentile values, whereas exclusion of individuals with an impaired estimated glomerular filtration rate (eGFR) or with prevalent coronary artery disease/myocardial infarction (CAD/MI) did not result in a meaningful change.CONCLUSIONS: Troponin I, measured by a high-sensitivity assay, can be reliably detected in the vast majority of the general population. hsTnI values were dependent on age, gender as well as structural and functional cardiac abnormalities.

KW - Blood Chemical Analysis/standards

KW - Europe

KW - Female

KW - Health Status

KW - Humans

KW - Limit of Detection

KW - Male

KW - Middle Aged

KW - Myocardium/metabolism

KW - Public Health

KW - Reference Values

KW - Troponin I/blood

U2 - 10.1515/cclm-2014-0619

DO - 10.1515/cclm-2014-0619

M3 - SCORING: Journal article

C2 - 25283141

VL - 53

SP - 699

EP - 706

JO - CLIN CHEM LAB MED

JF - CLIN CHEM LAB MED

SN - 1434-6621

IS - 5

ER -