High-sensitivity cardiac troponin I in the general population--defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study
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High-sensitivity cardiac troponin I in the general population--defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study. / Zeller, Tanja; Ojeda, Francisco; Brunner, Fabian J; Peitsmeyer, Philipp; Münzel, Thomas; Binder, Harald; Pfeiffer, Norbert; Michal, Matthias; Wild, Philipp S; Blankenberg, Stefan; Lackner, Karl J.
in: CLIN CHEM LAB MED, Jahrgang 53, Nr. 5, 04.2015, S. 699-706.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - High-sensitivity cardiac troponin I in the general population--defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study
AU - Zeller, Tanja
AU - Ojeda, Francisco
AU - Brunner, Fabian J
AU - Peitsmeyer, Philipp
AU - Münzel, Thomas
AU - Binder, Harald
AU - Pfeiffer, Norbert
AU - Michal, Matthias
AU - Wild, Philipp S
AU - Blankenberg, Stefan
AU - Lackner, Karl J
PY - 2015/4
Y1 - 2015/4
N2 - BACKGROUND: The 99th percentile of cardiac troponin levels, determined in a reference population, is accepted as threshold for diagnosis of acute myocardial infarction (AMI). However, there is no common consensus of how to define the reference population. The aim of the present study was to determine 99th percentile reference values, determined by a high-sensitivity assay (hsTnI), according to different health status and cardiovascular risk factor prevalence in a large population-based sample.METHODS: Troponin I was determined using the Abbott ARCHITECT STAT highly sensitive troponin I immunoassay in 4138 participants of the Gutenberg Health Study.RESULTS: hsTnI was detectable in 81.6% of all individuals. The 99th percentile of the overall population was 27 ng/L. Age and gender had a prominent influence on these values. Exclusion of individuals with elevated natriuretic peptide levels or cardiac abnormalities resulted in lower 99th percentile values, whereas exclusion of individuals with an impaired estimated glomerular filtration rate (eGFR) or with prevalent coronary artery disease/myocardial infarction (CAD/MI) did not result in a meaningful change.CONCLUSIONS: Troponin I, measured by a high-sensitivity assay, can be reliably detected in the vast majority of the general population. hsTnI values were dependent on age, gender as well as structural and functional cardiac abnormalities.
AB - BACKGROUND: The 99th percentile of cardiac troponin levels, determined in a reference population, is accepted as threshold for diagnosis of acute myocardial infarction (AMI). However, there is no common consensus of how to define the reference population. The aim of the present study was to determine 99th percentile reference values, determined by a high-sensitivity assay (hsTnI), according to different health status and cardiovascular risk factor prevalence in a large population-based sample.METHODS: Troponin I was determined using the Abbott ARCHITECT STAT highly sensitive troponin I immunoassay in 4138 participants of the Gutenberg Health Study.RESULTS: hsTnI was detectable in 81.6% of all individuals. The 99th percentile of the overall population was 27 ng/L. Age and gender had a prominent influence on these values. Exclusion of individuals with elevated natriuretic peptide levels or cardiac abnormalities resulted in lower 99th percentile values, whereas exclusion of individuals with an impaired estimated glomerular filtration rate (eGFR) or with prevalent coronary artery disease/myocardial infarction (CAD/MI) did not result in a meaningful change.CONCLUSIONS: Troponin I, measured by a high-sensitivity assay, can be reliably detected in the vast majority of the general population. hsTnI values were dependent on age, gender as well as structural and functional cardiac abnormalities.
KW - Blood Chemical Analysis/standards
KW - Europe
KW - Female
KW - Health Status
KW - Humans
KW - Limit of Detection
KW - Male
KW - Middle Aged
KW - Myocardium/metabolism
KW - Public Health
KW - Reference Values
KW - Troponin I/blood
U2 - 10.1515/cclm-2014-0619
DO - 10.1515/cclm-2014-0619
M3 - SCORING: Journal article
C2 - 25283141
VL - 53
SP - 699
EP - 706
JO - CLIN CHEM LAB MED
JF - CLIN CHEM LAB MED
SN - 1434-6621
IS - 5
ER -