Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates
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Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates. / Yasinska, Inna M; Ceccone, Giacomo; Ojea-Jimenez, Isaac; Ponti, Jessica; Hussain, Rohanah; Siligardi, Giuliano; Berger, Steffen M; Fasler-Kan, Elizaveta; Bardelli, Marco; Varani, Luca; Fiedler, Walter; Wellbrock, Jasmin; Raap, Ulrike; Gibbs, Bernhard F; Calzolai, Luigi; Sumbayev, Vadim V.
In: NANOSCALE, Vol. 10, No. 13, 29.03.2018, p. 5827-5833.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates
AU - Yasinska, Inna M
AU - Ceccone, Giacomo
AU - Ojea-Jimenez, Isaac
AU - Ponti, Jessica
AU - Hussain, Rohanah
AU - Siligardi, Giuliano
AU - Berger, Steffen M
AU - Fasler-Kan, Elizaveta
AU - Bardelli, Marco
AU - Varani, Luca
AU - Fiedler, Walter
AU - Wellbrock, Jasmin
AU - Raap, Ulrike
AU - Gibbs, Bernhard F
AU - Calzolai, Luigi
AU - Sumbayev, Vadim V
PY - 2018/3/29
Y1 - 2018/3/29
N2 - In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.
AB - In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.
KW - Journal Article
U2 - 10.1039/c7nr09436a
DO - 10.1039/c7nr09436a
M3 - SCORING: Journal article
C2 - 29538473
VL - 10
SP - 5827
EP - 5833
JO - NANOSCALE
JF - NANOSCALE
SN - 2040-3364
IS - 13
ER -