Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

Inna M Yasinska; Giacomo Ceccone; Isaac Ojea-Jimenez; Jessica Ponti; Rohanah Hussain; Giuliano Siligardi; Steffen M Berger; Elizaveta Fasler-Kan; Marco Bardelli; Luca Varani; Walter Fiedler; Jasmin Wellbrock; Ulrike Raap; Bernhard F Gibbs; Luigi Calzolai; Vadim V Sumbayev

doi:10.1039/c7nr09436a

Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

Inna M Yasinska
Giacomo Ceccone
Isaac Ojea-Jimenez
Jessica Ponti
Rohanah Hussain
Giuliano Siligardi
Steffen M Berger
Elizaveta Fasler-Kan
Marco Bardelli
Luca Varani
Walter Fiedler
Jasmin Wellbrock
Ulrike Raap
Bernhard F Gibbs
Luigi Calzolai
Vadim V Sumbayev

Related Research units

II. Department of Medicine

Abstract

In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.

Bibliographical data

Original language	English
ISSN	2040-3364
DOIs	https://doi.org/10.1039/c7nr09436a
Publication status	Published - 29.03.2018

PubMed	29538473