Get a grip: Podosomes as potential players in phagocytosis

Stefan Linder; Bryan Barcelona

doi:10.1016/j.ejcb.2023.151356

Get a grip: Podosomes as potential players in phagocytosis

Standard

Get a grip: Podosomes as potential players in phagocytosis. / Linder, Stefan ; Barcelona, Bryan.

In: EUR J CELL BIOL, Vol. 102, No. 4, 151356, 12.2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Linder, S & Barcelona, B 2023, 'Get a grip: Podosomes as potential players in phagocytosis', EUR J CELL BIOL, vol. 102, no. 4, 151356. https://doi.org/10.1016/j.ejcb.2023.151356

APA

Linder, S., & Barcelona, B. (2023). Get a grip: Podosomes as potential players in phagocytosis. EUR J CELL BIOL, 102(4), [151356]. https://doi.org/10.1016/j.ejcb.2023.151356

Vancouver

Linder S , Barcelona B. Get a grip: Podosomes as potential players in phagocytosis. EUR J CELL BIOL. 2023 Dec;102(4). 151356. https://doi.org/10.1016/j.ejcb.2023.151356

Bibtex

@article{9c9dff1ad56f4ca38b62d107a79b4acb,

title = "Get a grip: Podosomes as potential players in phagocytosis",

abstract = "Podosomes have been known for several decades as micron-sized, F-actin-rich structures that play a pivotal role in cell migration and invasion, as they are able to mediate both cell-matrix attachment as well as extracellular matrix degradation. Particularly in monocytic cells, podosomes have been shown to fulfill a variety of additional functions such as sensing of substrate rigidity and topography, or cell-cell fusion. Increasing evidence now points to the involvement of podosome-like structures also during phagocytosis by immune cells such as macrophages, dendritic cells, and neutrophils. Here, we compare the different cell models and experimental set ups where {"}phagocytic podosomes{"} have been described. We also discuss the composition and architecture of these structures, their potential involvement in mechanosensing and particle disruption, as well as the pros and cons for addressing them as bona fide podosomes.",

author = "Stefan Linder and Bryan Barcelona",

year = "2023",

month = dec,

doi = "10.1016/j.ejcb.2023.151356",

language = "English",

volume = "102",

journal = "EUR J CELL BIOL",

issn = "0171-9335",

publisher = "Urban und Fischer Verlag GmbH und Co. KG",

number = "4",

}

RIS

TY - JOUR

T1 - Get a grip: Podosomes as potential players in phagocytosis

AU - Linder, Stefan

AU - Barcelona, Bryan

PY - 2023/12

Y1 - 2023/12

N2 - Podosomes have been known for several decades as micron-sized, F-actin-rich structures that play a pivotal role in cell migration and invasion, as they are able to mediate both cell-matrix attachment as well as extracellular matrix degradation. Particularly in monocytic cells, podosomes have been shown to fulfill a variety of additional functions such as sensing of substrate rigidity and topography, or cell-cell fusion. Increasing evidence now points to the involvement of podosome-like structures also during phagocytosis by immune cells such as macrophages, dendritic cells, and neutrophils. Here, we compare the different cell models and experimental set ups where "phagocytic podosomes" have been described. We also discuss the composition and architecture of these structures, their potential involvement in mechanosensing and particle disruption, as well as the pros and cons for addressing them as bona fide podosomes.

AB - Podosomes have been known for several decades as micron-sized, F-actin-rich structures that play a pivotal role in cell migration and invasion, as they are able to mediate both cell-matrix attachment as well as extracellular matrix degradation. Particularly in monocytic cells, podosomes have been shown to fulfill a variety of additional functions such as sensing of substrate rigidity and topography, or cell-cell fusion. Increasing evidence now points to the involvement of podosome-like structures also during phagocytosis by immune cells such as macrophages, dendritic cells, and neutrophils. Here, we compare the different cell models and experimental set ups where "phagocytic podosomes" have been described. We also discuss the composition and architecture of these structures, their potential involvement in mechanosensing and particle disruption, as well as the pros and cons for addressing them as bona fide podosomes.

U2 - 10.1016/j.ejcb.2023.151356

DO - 10.1016/j.ejcb.2023.151356

M3 - SCORING: Journal article

C2 - 37625234

VL - 102

JO - EUR J CELL BIOL

JF - EUR J CELL BIOL

SN - 0171-9335

IS - 4

M1 - 151356

ER -