Get a grip: Podosomes as potential players in phagocytosis
Related Research units
Abstract
Podosomes have been known for several decades as micron-sized, F-actin-rich structures that play a pivotal role in cell migration and invasion, as they are able to mediate both cell-matrix attachment as well as extracellular matrix degradation. Particularly in monocytic cells, podosomes have been shown to fulfill a variety of additional functions such as sensing of substrate rigidity and topography, or cell-cell fusion. Increasing evidence now points to the involvement of podosome-like structures also during phagocytosis by immune cells such as macrophages, dendritic cells, and neutrophils. Here, we compare the different cell models and experimental set ups where "phagocytic podosomes" have been described. We also discuss the composition and architecture of these structures, their potential involvement in mechanosensing and particle disruption, as well as the pros and cons for addressing them as bona fide podosomes.
Bibliographical data
Original language | English |
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Article number | 151356 |
ISSN | 0171-9335 |
DOIs | |
Publication status | Published - 12.2023 |
Comment Deanary
Copyright © 2023 The Authors. Published by Elsevier GmbH.. All rights reserved.
PubMed | 37625234 |
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