DNA Repair
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DNA Repair. / Borgmann, Kerstin; Köcher, Sabrina; Kriegs, Malte; Mansour Khalfallah, Wael Yassin; Parplys, Ann Christin; Rieckmann, Thorsten; Rothkamm, Kai.
Molecular Radio-Oncology. ed. / Michael Baumann; Mechthild Krause; Nils Cordes. Vol. 198 1. ed. Berlin Heidelberg : Springer, 2016. p. 1-24 (Recent Results in Cancer Research).Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
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TY - CHAP
T1 - DNA Repair
AU - Borgmann, Kerstin
AU - Köcher, Sabrina
AU - Kriegs, Malte
AU - Mansour Khalfallah, Wael Yassin
AU - Parplys, Ann Christin
AU - Rieckmann, Thorsten
AU - Rothkamm, Kai
PY - 2016
Y1 - 2016
N2 - Cellular chromosomal DNA is the principal target through which ionising radiation exerts it diverse biological effects. This chapter summarises the relevant DNA damage signalling and repair pathways used by normal and tumour cells in response to irradiation. Strategies for tumour radiosensitisation are reviewed which exploit tumour-specific DNA repair deficiencies or signalling pathway addictions, with a special focus on growth factor signalling, PARP, cancer stem cells, cell cycle checkpoints and DNA replication. This chapter concludes with a discussion of DNA repair-related candidate biomarkers of tumour response which are of crucial importance for implementing precision medicine in radiation oncology.
AB - Cellular chromosomal DNA is the principal target through which ionising radiation exerts it diverse biological effects. This chapter summarises the relevant DNA damage signalling and repair pathways used by normal and tumour cells in response to irradiation. Strategies for tumour radiosensitisation are reviewed which exploit tumour-specific DNA repair deficiencies or signalling pathway addictions, with a special focus on growth factor signalling, PARP, cancer stem cells, cell cycle checkpoints and DNA replication. This chapter concludes with a discussion of DNA repair-related candidate biomarkers of tumour response which are of crucial importance for implementing precision medicine in radiation oncology.
M3 - SCORING: Contribution to collected editions/anthologies
C2 - 27318679
SN - 978-3-662-49649-7
VL - 198
T3 - Recent Results in Cancer Research
SP - 1
EP - 24
BT - Molecular Radio-Oncology
A2 - Baumann, Michael
A2 - Krause, Mechthild
A2 - Cordes, Nils
PB - Springer
CY - Berlin Heidelberg
ER -