Research ExplorerScientific StaffWael Yassin Mansour Publications

Dr.rer.nat. ID: 43619

Wael Yassin Mansour

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Affiliations
ORCID: 0000-0003-0641-2885
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Publications

  1. 2024

  2. Synthesis and new DNA targeting activity of 6- and 7-tert-butylfascaplysins

    Dyshlovoy, S. A., Mansour, W. Y., Ramm, N. A., Hauschild, J., Zhidkov, M. E., Kriegs, M., Zielinski, A., Hoffer, K., Busenbender, T., Glumakova, K. A., Spirin, P. V., Prassolov, V. S., Tilki, D., Graefen, M., Bokemeyer, C. & von Amsberg, G., 23.05.2024, In: SCI REP-UK. 14, 1, p. 11788

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. Multimodal image-guided laser ablation system for precise 3D tissue sampling and subsequent analysis of biomolecules for cancer research

    Hahn, J., Moritz, M., Walter, A., Wieck, T., Moustafa, A., Mansour, W. Y., Harms, C., Stenzel, P., Heeren, J., Haider, M-T., Lange, T. & Schlüter, H., 2024, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII: 29-31 January 2024, San Francisco, California, United States. Tárnok, A. & Houston, J. P. (eds.). 1 ed. Bellingham, Washington: SPIE , 128460C. (Proceedings of SPIE; vol. 12846).

    Research output: SCORING: Contribution to book/anthology › Conference contribution - Article for conference › Research › peer-review

  4. 2023

  5. Preclinical patient-derived modeling of castration-resistant prostate cancer facilitates individualized assessment of homologous recombination repair deficient disease

    Elsesy, M. E., Oh-Hohenhorst, S. J., Oing, C., Eckhardt, A., Burdak-Rothkamm, S., Alawi, M., Müller, C., Schüller, U., Maurer, T., von Amsberg, G., Petersen, C., Rothkamm, K. & Mansour, W. Y., 06.2023, In: MOL ONCOL. 17, 6, p. 1129-1147 19 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. 2022

  7. Salvage Chemotherapy with Cisplatin, Ifosfamide, and Paclitaxel in Aggressive Variant of Metastatic Castration-Resistant Prostate Cancer

    Amsberg, G. V., Zilles, M., Mansour, W., Gild, P., Alsdorf, W., Kaune, M., Böckelmann, L. C., Hauschild, J., Krisp, C., Rohlfing, T., Saygi, C., Alawi, M., Zielinski, A., Langebrake, C., Su, X., Perner, S., Tilki, D., Schluter, H., Graefen, M., Dyshlovoy, S. & Bokemeyer, C., 29.11.2022, In: INT J MOL SCI. 23, 23, 14948.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Increased replication stress and R-loop accumulation in EGFRvIII expressing glioblastoma present new therapeutic opportunities

    Struve, N., Hoffer, K., Weik, A-S., Riepen, B., Krug, L., Cetin, M. H., Burmester, J., Ott, L., Liebing, J., Gatzemeier, F., Müller-Goebel, J., Bußmann, L., Parplys, A. C., Unger, K., Mansour, W. Y., Schüller, U., Rieckmann, T., Petersen, C., Rothkamm, K., Short, S. C. & Kriegs, M., 12.03.2022, In: NEURO-ONCOL ADV. 4, 1, p. vdab180 vdab180.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Patient derived ex vivo tissue slice cultures demonstrate a profound DNA double-strand break repair defect in HPV-positive oropharyngeal head and neck cancer

    Zech, H. B., Berger, J., Mansour, W. Y., Nordquist, L., von Bargen, C., Bußmann, L., Oetting, A., Christiansen, S., Möckelmann, N., Böttcher, A., Busch, C-J., Petersen, C., Betz, C., Rothkamm, K., Kriegs, M., Köcher, S. & Rieckmann, T., 03.2022, In: RADIOTHER ONCOL. 168, p. 138-146 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. A Lack of Effectiveness in the ATM-Orchestrated DNA Damage Response Contributes to the DNA Repair Defect of HPV-Positive Head and Neck Cancer Cells

    Köcher, S., Zech, H. B., Krug, L., Gatzemeier, F., Christiansen, S., Meyer, F., Rietow, R., Struve, N., Mansour, W. Y., Kriegs, M., Petersen, C., Betz, C., Rothkamm, K. & Rieckmann, T., 2022, In: FRONT ONCOL. 12, 765968.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. 2021

  12. Emerging Insights into Keratin 16 Expression during Metastatic Progression of Breast Cancer

    Elazezy, M., Schwentesius, S., Stegat, L., Wikman, H., Werner, S., Mansour, W. Y., Failla, A. V., Peine, S., Müller, V., Thiery, J. P., Ebrahimi Warkiani, M., Pantel, K. & Joosse, S. A., 31.07.2021, In: CANCERS. 13, 15, 3869.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Fully automated counting of DNA damage foci in tumor cell culture: A matter of cell separation

    Köcher, S., Volquardsen, J., Perugachi Heinsohn, A., Petersen, C., Roggenbuck, D., Rothkamm, K. & Mansour, W. Y., 06.2021, In: DNA REPAIR. 102, 103100.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. X-ray Fluorescence Uptake Measurement of Functionalized Gold Nanoparticles in Tumor Cell Microsamples

    Schmutzler, O., Graf, S., Behm, N., Mansour, W. Y., Blumendorf, F., Staufer, T., Körnig, C., Salah, D., Kang, Y., Peters, J. N., Liu, Y., Feliu, N., Parak, W. J., Burkhardt, A., Gargioni, E., Gennis, S., Chandralingam, S., Höeg, F., Maison, W., Rothkamm, K., Schulz, F. & Grüner, F., 01.04.2021, In: INT J MOL SCI. 22, 7, p. 3691

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. 2020

  16. DNA Damage Repair Deficiency in Prostate Cancer

    Burdak-Rothkamm, S., Mansour, W. Y. & Rothkamm, K., 11.2020, In: TRENDS CANCER. 6, 11, p. 974-984 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  17. Induction of DNA damage, apoptosis and cell cycle perturbation mediate cytotoxic activity of new 5-aminosalicylate-4-thiazolinone hybrid derivatives

    S Ramadan, W., Saleh, E. M., Menon, V., Vazhappilly, C. G., Abdu-Allah, H. H. M., El-Shorbagi, A-N. A., Mansour, W. & El-Awady, R., 11.2020, In: BIOMED PHARMACOTHER. 131, p. 110571

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Second-Generation Antiandrogen Therapy Radiosensitizes Prostate Cancer Regardless of Castration State through Inhibition of DNA Double Strand Break Repair

    Elsesy, M. E., Oh-Hohenhorst, S. J., Löser, A., Oing, C., Mutiara, S., Köcher, S., Meien, S., Zielinski, A., Burdak-Rothkamm, S., Tilki, D., Huland, H., Schwarz, R., Petersen, C., Bokemeyer, C., Rothkamm, K. & Mansour, W. Y., 31.08.2020, In: CANCERS. 12, 9

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer

    Meyer, F., Becker, S., Classen, S., Parplys, A. C., Mansour, W. Y., Riepen, B., Timm, S., Ruebe, C., Jasin, M., Wikman, H., Petersen, C., Rothkamm, K. & Borgmann, K., 17.01.2020, In: CELLS-BASEL. 9, 1

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. Establishment of a Transformation Coupled in vitro End Joining Assay to Estimate Radiosensitivity in Tumor Cells

    Degenhardt, S., Dreffke, K., Schötz, U., Petersen, C., Engenhart-Cabillic, R., Rothkamm, K., Dahm-Daphi, J., Dikomey, E. & Mansour, W. Y., 2020, In: FRONT ONCOL. 10, p. 1480

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. 2019

  22. A functional ex vivo assay to detect PARP1-EJ repair and radiosensitization by PARP-inhibitor in prostate cancer

    Köcher, S., Beyer, B., Lange, T., Nordquist, L., Volquardsen, J., Burdak-Rothkamm, S., Schlomm, T., Petersen, C., Rothkamm, K. & Mansour, W. Y., 01.04.2019, In: INT J CANCER. 144, 7, p. 1685-1696 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness

    Kari, V., Raul, S. K., Henck, J. M., Kitz, J., Kramer, F., Kosinsky, R. L., Übelmesser, N., Mansour, W. Y., Eggert, J., Spitzner, M., Najafova, Z., Bastians, H., Grade, M., Gaedcke, J., Wegwitz, F. & Johnsen, S. A., 07.01.2019, In: CLIN EPIGENETICS. 11, 1, p. 4

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. 2018

  25. 5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells

    Oing, C., Verem, I., Mansour, W. Y., Bokemeyer, C., Dyshlovoy, S. & Honecker, F., 21.12.2018, In: INT J MOL SCI. 20, 1, p. 21

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy

    Oing, C., Tennstedt, P., Simon, R., Volquardsen, J., Borgmann, K., Bokemeyer, C., Petersen, C., Dikomey, E., Rothkamm, K. & Mansour, W. Y., 01.06.2018, In: CANCER LETT. 423, p. 60-70 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer

    Mansour, W. Y., Tennstedt, P., Volquardsen, J., Oing, C., Kluth, M., Hube-Magg, C., Borgmann, K., Simon, R., Petersen, C., Dikomey, E. & Rothkamm, K., 02.03.2018, In: SCI REP-UK. 8, 1, p. 3947 1 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. 2017

  29. Monoubiquitination of histone H2B – a potential new target in treatment resistant germ cell tumors.

    Oing, C., Dyshlovoy, S., Burandt, E., Amsberg, G. V., Honecker, F., Bokemeyer, C., Rothkamm, K. & Mansour, W. Y., 2017, In: ONCOL RES TREAT. 40, p. 95-96

    Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review

  30. 2016

  31. Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

    Kari, V., Mansour Khalfallah, W. Y., Raul, S. K., Baumgart, S. J., Mund, A., Grade, M., Sirma, H., Simon, R., Will, H., Dobbelstein, M., Dikomey, E. & Johnsen, S. A., 11.2016, In: EMBO REP. 17, 11, p. 1609-1623 15 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1

    Bakr, A., Köcher, S., Volquardsen, J., Petersen, C., Borgmann, K., Dikomey, E., Rothkamm, K. & Mansour Khalfallah, W. Y., 06.09.2016, In: ONCOTARGET. 7, 36, p. 57679-57693

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer

    Toulany, M., Iida, M., Keinath, S., Iyi, F. F., Mueck, K., Fehrenbacher, B., Mansour Khalfallah, W. Y., Schaller, M., Wheeler, D. L. & Rodemann, H. P., 12.07.2016, In: ONCOTARGET. 7, 28, p. 43746-43761 16 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice

    Bakr, A., Köcher, S., Volquardsen, J., Reimer, R., Borgmann, K., Dikomey, E., Rothkamm, K. & Mansour Khalfallah, W. Y., 05.2016, In: RADIOTHER ONCOL. 119, 2, p. 276-81 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response

    Wurster, S., Hennes, F., Parplys, A. C., Seelbach, J. I., Mansour Khalfallah, W. Y., Zielinski, A., Petersen, C., Clauditz, T. S., Münscher, A., Friedl, A. A. & Borgmann, K., 01.03.2016, In: ONCOTARGET. 7, 9, p. 9732-41

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  36. Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair

    Penterling, C., Drexler, G. A., Böhland, C., Stamp, R., Wilke, C., Braselmann, H., Caldwell, R. B., Reindl, J., Girst, S., Greubel, C., Siebenwirth, C., Mansour Khalfallah, W. Y., Borgmann, K., Dollinger, G., Unger, K. & Friedl, A. A., 2016, In: PLOS ONE. 11, 6, p. e0156599

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. DNA Repair

    Borgmann, K., Köcher, S., Kriegs, M., Mansour Khalfallah, W. Y., Parplys, A. C., Rieckmann, T. & Rothkamm, K., 2016, Molecular Radio-Oncology. Baumann, M., Krause, M. & Cordes, N. (eds.). 1 ed. Berlin Heidelberg: Springer, Vol. 198. p. 1-24 24 p. (Recent Results in Cancer Research).

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  38. DNA repair after oncological therapy (radiotherapy and chemotherapy)

    Dikomey, E., Borgmann, K., Kriegs, M., Mansour Khalfallah, W. Y., Petersen, C. & Rieckmann, T., 2016, Oxford Textbook of Oncology. Kerr, D. J., Haller, D. G., van de Velde, C. J. H. & Baumann, M. (eds.). 3 ed. Oxford: Oxford University Press, p. 82-85 4 p. Chapter 9

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  39. PARP-Inhibition - eine neue Therapieoption bei Prostatakarzinomen mit DNA-Reparaturdefizienz

    Oing, C., Mansour, W. Y. & Bokemeyer, C., 2016, In: InFo Onkologie. 02, p. 2-3

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  40. Radiation DNA damage and use in cancer/therapeutics-translation of radiation modifiers

    Dikomey, E., Borgmann, K., Köcher, S., Kriegs, M., Mansour Khalfallah, W. Y., Parplys, A. C., Rieckmann, T. & Rothkamm, K., 2016, DNA Repair in Cancer Therapy: Molecular Targets and Clinical Applications. Kelley, M. R. & Fishel, M. L. (eds.). 2 ed. London: Elsevier Science, p. 329 - 352 23 p. Chapter11

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  41. 2015

  42. High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation

    Parplys, A. C., Seelbach, J. I., Becker, S., Behr, M., Wrona, A., Jend, C., Mansour Khalfallah, W. Y., Joosse, S. A., Stuerzbecher, H-W., Pospiech, H., Petersen, C., Dikomey, E. & Borgmann, K., 02.10.2015, In: CELL CYCLE. 14, 19, p. 3190-202 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. 5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair

    Srinivas, U. S., Dyczkowski, J., Beißbarth, T., Gaedcke, J., Mansour Khalfallah, W. Y., Borgmann, K. & Dobbelstein, M., 20.05.2015, In: ONCOTARGET. 6, 14, p. 12574-86 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation

    Bakr, A., Oing, C., Köcher, S., Borgmann, K., Dornreiter, I., Petersen, C., Dikomey, E. & Mansour Khalfallah, W. Y., 31.03.2015, In: NUCLEIC ACIDS RES. 43, 6, p. 3154-66 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. 2014

  46. Inhibition of PARP1-dependent end-joining contributes to Olaparib-mediated radiosensitization in tumor cells

    Kötter, A., Cornils, K., Borgmann, K., Dahm-Daphi, J., Petersen, C., Dikomey, E. & Mansour Khalfallah, W. Y., 01.12.2014, In: MOL ONCOL. 8, 8, p. 1616-25 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. 2013

  48. The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining

    Mansour Khalfallah, W. Y., Borgmann, K., Petersen, C., Dikomey, E. & Dahm-Daphi, J., 01.12.2013, In: DNA REPAIR. 12, 12, p. 1134-42 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma.

    Mansour Khalfallah, W. Y., Bogdanova, N. V., Kasten-Pisula, U., Rieckmann, T., Köcher, S., Borgmann, K., Baumann, M., Krause, M., Petersen, C., Hu, H., Gatti, R. A., Dikomey, E., Dörk, T. & Dahm-Daphi, J., 2013, In: RADIOTHER ONCOL. 106, 1, p. 147-154 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  50. 2012

  51. Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase.

    Köcher, S., Rieckmann, T., Rohaly, G., Mansour, W., Dikomey, E., Dornreiter, I. & Dahm-Daphi, J., 2012, In: NUCLEIC ACIDS RES. 40, 17, p. 8336-8347 17.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  52. 2010

  53. The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies.

    Mansour, W., Rhein, T. & Dahm-Daphi, J., 2010, In: NUCLEIC ACIDS RES. 38, 18, p. 6065-6077 18.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  54. 2009

  55. The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair.

    Kasten-Pisula, U., Menegakis, A., Brammer, I., Borgmann, K., Mansour, W., Degenhardt, S., Krause, M., Schreiber, A., Dahm-Daphi, J., Petersen, C., Dikomey, E. & Baumann, M., 2009, In: RADIOTHER ONCOL. 90, 2, p. 257-264 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  56. 2008

  57. Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks.

    Mansour, W., Schumacher, S., Rosskopf, R., Rhein, T., Schmidt-Petersen, F., Gatzemeier, F., Haag, F., Borgmann, K., Willers, H. & Dahm-Daphi, J., 2008, In: NUCLEIC ACIDS RES. 36, 12, p. 4088-4098 12.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review