Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma.
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Abstract
Cellular and clinical sensitivity to ionizing radiation (IR) is determined by DNA double-strand breaks (DSB) repair. Here, we investigate the molecular mechanism underlying the extreme response of a head and neck tumor case (SKX) to standard radiotherapy.
Bibliographical data
| Original language | English |
|---|---|
| Article number | 1 |
| ISSN | 0167-8140 |
| Publication status | Published - 2013 |
| pubmed | 23199656 |
|---|
