Dr. ID: 36004
Michaela Schweizer
Publications
- 2018
Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity
Schmiesing, J., Storch, S., Dörfler, A-C., Schweizer, M., Makrypidi-Fraune, G., Thelen, M., Sylvester, M., Gieselmann, V., Meyer-Schwesinger, C., Koch-Nolte, F., Tidow, H., Mühlhausen, C., Waheed, A., Sly, W. S. & Braulke, T., 11.09.2018, In: CELL REP. 24, 11, p. 2946-2956 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15
Seipold, L., Altmeppen, H., Koudelka, T., Tholey, A., Kasparek, P., Sedlacek, R., Schweizer, M., Bär, J., Mikhaylova, M., Glatzel, M. & Saftig, P., 09.2018, In: CELL MOL LIFE SCI. 75, 17, p. 3251-3267 17 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lysosomal Proteome and Secretome Analysis Identifies Missorted Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse Cells
Di Lorenzo, G., Velho, R. V., Winter, D., Thelen, M., Ahmadi, S., Schweizer, M., De Pace, R., Cornils, K., Yorgan, T. A., Grüb, S., Hermans-Borgmeyer, I., Schinke, T., Müller-Loennies, S., Braulke, T. & Pohl, S., 08.2018, In: MOL CELL PROTEOMICS. 17, 8, p. 1612-1626 15 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes
Gonzalez, A. C., Schweizer, M., Jagdmann, S., Bernreuther, C., Reinheckel, T., Saftig, P. & Damme, M., 23.01.2018, In: CELL REP. 22, 4, p. 1040-1053 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2017
Site-1 protease and lysosomal homeostasis
Velho, R. V., De Pace, R., Klünder, S., Di Lorenzo, G., Schweizer, M., Braulke, T. & Pohl, S., 11.2017, In: BBA-MOL CELL RES. 1864, 11 Pt B, p. 2162-2168Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior
Hu, C., Petersen, M., Hoyer, N., Spitzweck, B., Tenedini, F., Wang, D., Gruschka, A., Burchardt, L. S., Szpotowicz, E., Schweizer, M., Guntur, A. R., Yang, C-H. & Soba, P., 08.2017, In: NAT NEUROSCI. 20, 8, p. 1085-1095Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments
Schneppenheim, J., Loock, A-C., Hüttl, S., Schweizer, M., Lüllmann-Rauch, R., Oberg, H-H., Arnold, P., Lehmann, C. H. K., Dudziak, D., Kabelitz, D., Lucius, R., Lennon-Duménil, A-M., Saftig, P. & Schröder, B., 01.07.2017, In: J IMMUNOL. 199, 1, p. 172-185 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction
Grochowska, K. M., Yuanxiang, P., Bär, J., Raman, R., Brugal, G., Sahu, G., Schweizer, M., Bikbaev, A., Schilling, S., Demuth, H-U. & Kreutz, M. R., 06.2017, In: EMBO REP. 18, 6, p. 962-981Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Proteomics insights into infantile neuronal ceroid lipofuscinosis (CLN1) point to the involvement of cilia pathology in the disease
Segal-Salto, M., Hansson, K., Sapir, T., Kaplan, A., Levy, T., Schweizer, M., Frotscher, M., James, P. & Reiner, O., 01.05.2017, In: HUM MOL GENET. 26, 9, p. 1678Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II
Markmann, S., Krambeck, S., Hughes, C. J., Mirzaian, M., Aerts, J. M. F. G., Saftig, P., Schweizer, M., Vissers, J. P. C., Braulke, T. & Damme, M., 03.2017, In: MOL CELL PROTEOMICS. 16, 3, p. 438-450 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Disease-causing mutations affecting surface residues of mitochondrial glutaryl-CoA dehydrogenase impair stability, heteromeric complex formation, and mitochondria architecture
Schmiesing, J., Lohmöller, B., Schweizer, M., Tidow, H., Gersting, S. W., Muntau, A. C., Braulke, T. & Mühlhausen, C., 01.02.2017, In: HUM MOL GENET. 26, 3, p. 538-551Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Formation of Calcified Nanospherites during Micropetrosis Represents a Unique Mineralization Mechanism in Aged Human Bone
Milovanovic, P., Zimmermann, E. A., vom Scheidt, A., Hoffmann, B., Sarau, G., Yorgan, T., Schweizer, M., Amling, M., Christiansen, S. & Busse, B., 18.01.2017, In: SMALL. 13, 3, p. n/a-n/aResearch output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2016
Mannose 6-phosphate-dependent targeting of lysosomal enzymes is required for normal craniofacial and dental development
Koehne, T., Markmann, S., Schweizer, M., Muschol, N., Friedrich, R. E., Hagel, C., Glatzel, M., Kahl-Nieke, B., Amling, M., Schinke, T. & Braulke, T., 09.2016, In: BBA-MOL BASIS DIS. 1862, 9, p. 1570–1580Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mesenchymal Stromal/Stem Cells Do Not Ameliorate Experimental Autoimmune Encephalomyelitis and Are Not Detectable in the Central Nervous System of Transplanted Mice
Abramowski, P., Krasemann, S., Ernst, T., Lange, C., Ittrich, H., Schweizer, M., Zander, A. R., Martin, R. & Fehse, B., 01.08.2016, In: STEM CELLS DEV. 25, 15, p. 1134-48Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory
Muhia, M., Thies, E., Labonté, D., Ghiretti, A. E., Gromova, K. V., Xompero, F., Lappe-Siefke, C., Hermans-Borgmeyer, I., Kuhl, D., Schweizer, M., Ohana, O., Schwarz, J., Holzbaur, E. L. F. & Kneussel, M., 03.05.2016, In: CELL REP. 15, 5, p. 968-77 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Rsk2, the kinase in Coffin-Lowry syndrome controls cementum formation
Koehne, T., Jeschke, A., Petermann, F., Seitz, S., Neven, M., Peters, S., Luther, J., Schweizer, M., Schinke, T., Kahl-Nieke, B., Amling, M. & David, J-P., 29.02.2016, In: J DENT RES. 95, 7, p. 752-760Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lysosomal dysfunction and impaired autophagy in a novel mouse model deficient for the lysosomal membrane protein Cln7
Brandenstein, L., Schweizer, M., Sedlacik, J., Fiehler, J. & Storch, S., 15.02.2016, In: HUM MOL GENET. 25, 4, p. 777-91Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
Kuhn, P-H., Colombo, A. V., Schusser, B., Dreymueller, D., Wetzel, S., Schepers, U., Herber, J., Ludwig, A., Kremmer, E., Montag, D., Müller, U., Schweizer, M., Saftig, P., Bräse, S. & Lichtenthaler, S. F., 23.01.2016, In: ELIFE. 5, p. e12748Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines
Köster, J-D., Leggewie, B., Blechner, C., Brandt, N., Fester, L., Rune, G., Schweizer, M., Kindler, S. & Windhorst, S., 01.2016, In: CELL SIGNAL. 28, 1, p. 83-90 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2015
Impaired bone remodeling and its correction by combination therapy in a mouse model of mucopolysaccharidosis-I
Kühn, S. C., Koehne, T., Cornils, K., Markmann, S., Riedel, C., Pestka, J. M., Schweizer, M., Baldauf, C., Yorgan, T. A., Krause, M., Keller, J., Neven, M., Breyer, S., Stücker, R., Muschol, N., Busse, B., Braulke, T., Fehse, B., Amling, M. & Schinke, T., 15.12.2015, In: HUM MOL GENET. 24, 24, p. 7075-7086Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells
Jeschke, A., Catala-Lehnen, P., Sieber, S., Bickert, T., Schweizer, M., Koehne, T., Wintges, K., Marshall, R. P., Mautner, A., Duchstein, L., Otto, B., Horst, A. K., Amling, M., Kreienkamp, H-J. & Schinke, T., 15.10.2015, In: J IMMUNOL. 195, 8, p. 3675-84 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical fot B Cell Receptor Signaling in Transitional B Cells.
Hüttl, S., Kläsener, K., Schweizer, M., Schneppenheim, J., Oberg, H-H., Kabelitz, D., Reth, M., Saftig, P. & Schröder, B., 15.08.2015, In: J IMMUNOL. 195 , 4, p. 1548-1563Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Biological Relevance and Therapeutic Potential of the Hypusine Modification System
Pallmann, N., Braig, M., Sievert, H., Preukschas, M., Hermans-Borgmeyer, I., Schweizer, M., Nagel, C. H., Neumann, M., Wild, P., Haralambieva, E., Hagel, C., Bokemeyer, C., Hauber, J. & Balabanov, S., 02.06.2015, In: J BIOL CHEM. 290, 30, p. 18343-18360Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lrp1/LDL receptor play critical roles in mannose 6-phosphate-independent lysosomal enzyme targeting
Markmann, S., Thelen, M., Cornils, K., Schweizer, M., Brocke-Ahmadinejad, N., Willnow, T., Heeren, J., Gieselmann, V., Braulke, T. & Kollmann, K., 18.03.2015, In: TRAFFIC.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease
Rothaug, M., Stroobants, S., Schweizer, M., Peters, J., Zunke, F., Allerding, M., D Hooge, R., Saftig, P. & Blanz, J., 31.01.2015, In: ACTA NEUROPATHOL COM. 3, 1, p. 6Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions
Otomo, T., Schweizer, M., Kollmann, K., Schumacher, V., Muschol, N., Tolosa, E., Mittrücker, H-W. & Braulke, T., 19.01.2015, In: J CELL BIOL. 208, 2, p. 171-80 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2014
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance
Rothaug, M., Zunke, F., Mazzulli, J. R., Schweizer, M., Altmeppen, H., Lüllmann-Rauch, R., Kallemeijn, W. W., Gaspar, P., Aerts, J. M., Glatzel, M., Saftig, P., Krainc, D., Schwake, M. & Blanz, J., 28.10.2014, In: P NATL ACAD SCI USA. 111, 43, p. 15573-8 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A spastic paraplegia mouse model reveals REEP1-dependent ER shaping
Beetz, C., Koch, N., Khundadze, M., Zimmer, G., Nietzsche, S., Hertel, N., Huebner, A-K., Mumtaz, R., Schweizer, M., Dirren, E., Karle, K. N., Irintchev, A., Alvarez, V., Redies, C., Westermann, M., Kurth, I., Deufel, T., Kessels, M. M., Qualmann, B. & Hübner, C. A., 02.06.2014, In: J CLIN INVEST. 124, 6, p. 2809Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
A novel mouse model for inhibition of DOHH mediated hypusine modification reveals crucial function for embryonic development, proliferation and oncogenic transformation
Sievert, H., Pällmann, N., Miller, K. K., Hermans-Borgmeyer, I., Venz, S., Sendoel, A., Preukschas, M., Schweizer, M., Böttcher, S., Janiesch, P. C., Streichert, T., Walther, R., Hengartner, M. O., Manz, M. G., Brümmendorf, T. H., Bokemeyer, C., Balabanov, M., Hauber, J., Duncan, K. E. & Balabanov, S., 15.05.2014, In: DIS MODEL MECH.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Gene disruption of Mfsd8 in mice provides the first animal model for CLN7 disease
Damme, M., Brandenstein, L., Fehr, S., Jankowiak, W., Bartsch, U., Schweizer, M., Hermans-Borgmeyer, I. & Storch, S., 01.05.2014, In: NEUROBIOL DIS. 65, p. 12-24 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites
Heisler, F. F., Lee, H. K., Gromova, K. V., Pechmann, Y., Schurek, B., Ruschkies, L., Schroeder, M., Schweizer, M. & Kneussel, M., 2014, In: P NATL ACAD SCI USA. 111, 13, p. 5030-5 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders
Kurt, S., Zuccotti, A., Pirone, A., Rüttiger, L., Pilz, P., Brown, D. H., Franz, C., Schweizer, M., Rust, M. B., Rübsamen, R., Friauf, E., Knipper, M. & Engel, J., 2014, In: J NEUROSCI. 34, 2, p. 434-45 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2013
Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II
Kollmann, K., Pestka, J-M., Kühn, S. C., Schöne, E., Schweizer, M., Karkmann, K., Otomo, T., Catala-Lehnen, P., Failla, A. V., Marshall, R. P., Krause, M., Santer, R., Amling, M., Braulke, T. & Schinke, T., 01.12.2013, In: EMBO MOL MED. 5, 12, p. 1871-86 16 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Acute renal proximal tubule alterations during induced metabolic crises in a mouse model of glutaric aciduria type 1
Thies, B., Meyer-Schwesinger, C., Lamp, J., Schweizer, M., Koeller, D. M., Ullrich, K., Braulke, T. & Mühlhausen, C., 01.10.2013, In: BBA-MOL BASIS DIS. 1832, 10, p. 1463-72 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5)
Wintges, K., Beil, F. T., Albers, J., Jeschke, A., Schweizer, M., Claass, B., Tiegs, G., Amling, M. & Schinke, T., 01.10.2013, In: J BONE MINER RES. 28, 10, p. 2070-80 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Ultrastructural analysis of neuronal and non-neuronal lysosomal storage in mucolipidosis type II knock-in mice
Schweizer, M., Markmann, S., Braulke, T. & Kollmann, K., 01.10.2013, In: ULTRASTRUCT PATHOL. 37, 5, p. 366-72 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions
Prox, J., Bernreuther, C., Altmeppen, H., Grendel, J., Glatzel, M., D'Hooge, R., Stroobants, S., Ahmed, T., Balschun, D., Willem, M., Lammich, S., Isbrandt, D., Schweizer, M., Horré, K., De Strooper, B. & Saftig, P., 07.08.2013, In: J NEUROSCI. 33, 32, p. 12915-28, 12928aResearch output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A novel interaction between aging and ER overload in a protein conformational dementia
Schipanski, A., Lange, S., Segref, A., Gutschmidt, A., Lomas, D. A., Miranda, E., Schweizer, M., Hoppe, T. & Glatzel, M., 01.03.2013, In: GENETICS. 193, 3, p. 865-76 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons
Zivraj, K. H., Rehbein, M., Ölschläger-Schütt, J., Schob, C., Falley, K., Buck, F., Schweizer, M., Schepis, A., Kremmer, E., Richter, D., Kreienkamp, H-J. & Kindler, S., 01.03.2013, In: J NEUROCHEM. 124, 5, p. 670-84 15 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma
Grapp, M., Wrede, A., Schweizer, M., Hüwel, S., Galla, H-J., Snaidero, N., Simons, M., Bückers, J., Low, P. S., Urlaub, H., Gärtner, J. & Steinfeld, R., 01.01.2013, In: NAT COMMUN. 4, p. 2123Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Malignant H1299 tumour cells preferentially internalize iron-bound inositol hexakisphosphate
Helmis, C., Blechner, C., Lin, H., Schweizer, M., Mayr, G. W., Nielsen, P. & Windhorst, S., 01.01.2013, In: BIOSCIENCE REP. 33, 5Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2012
Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis.
Thelen, M., Damme, M., Daμμe, M., Schweizer, M., Hagel, C., Wong, A. M. S., Cooper, J. D., Braulke, T. & Galliciotti, G., 2012, In: PLOS ONE. 7, 4, p. 35493 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High expression of disease-related Cln6 in the cerebral cortex, purkinje cells, dentate gyrus, and hippocampal ca1 neurons.
Thelen, M., Fehr, S., Schweizer, M., Braulke, T. & Galliciotti, G., 2012, In: J NEUROSCI RES. 90, 3, p. 568-574 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.
Kollmann, K., Damme, M., Markmann, S., Morelle, W., Schweizer, M., Hermans-Borgmeyer, I., Röchert, A. K., Pohl, S., Lübke, T., Michalski, J-C., Käkelä, R., Walkley, S. U. & Braulke, T., 2012, In: BRAIN. 135, Pt 9, p. 2661-2675 Pt 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
M-phase phosphoprotein 11 is a highly immunogenic tumor antigen in patients with acute myeloid leukemia.
Siegel, S., Wirth, S., Schweizer, M., Schmitz, N. & Zeis, M., 2012, In: ACTA HAEMATOL-BASEL. 127, 4, p. 193-197 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2011
A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism.
Marschner, K., Kollmann, K., Schweizer, M., Braulke, T. & Pohl, S., 2011, In: SCIENCE. 333, 6038, p. 87-90 6038.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissue.
Hein, S., Müller, V., Köhler, N., Wikman, H., Krenkel, S., Streichert, T., Schweizer, M., Riethdorf, S., Assmann, V., Henningsen, M., Beck, K., Issa, R., Jänicke, F., Pantel, K. & Milde-Langosch, K., 2011, In: BREAST CANCER RES TR. 129, 2, p. 347-360 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impaired stria vascularis integrity upon loss of E-cadherin in basal cells.
Trowe, M-O., Maier, H., Petry, M., Schweizer, M., Schuster-Gossler, K. & Kispert, A., 2011, In: DEV BIOL. 359, 1, p. 95-107 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.
Heisler, F., Löbrich, S., Pechmann, Y., Maier, N., Zivkovic, A. R., Tokito, M., Hausrat, T., Schweizer, M., Bähring, R., Holzbaur, E. L. F., Schmitz, D. & Kneussel, M., 2011, In: NEURON. 70, 1, p. 66-81 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Synapsin I is an oligomannose-carrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes.
Wang, S., Cesca, F., Loers, G., Schweizer, M., Buck, F., Benfenati, F., Schachner, M. & Kleene, R., 2011, In: J NEUROSCI. 31, 20, p. 7275-7290 20.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review