Research ExplorerScientific StaffManfred Jücker Publications

Prof.Dr. ID: 59733

Manfred Jücker

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Publications

  1. "Alkohol und Nikotin"-Konzept und Evaluation eines interdisziplinären Wahlfachs mit OSPE im Studienabschnitt Medizin 1

    Bergelt, C., Lauke-Wettwer, H., Petersen-Ewert, C., Jücker, M. & Bauer, C. K., 2014, In: GMS Z Med Ausbild. 31, 1, p. 1-20 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Education › peer-review

  2. Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling.

    Brauer, H., Strauss, J., Wegner, W., Müller-Tidow, C., Horstmann, M. & Jücker, M., 2012, In: CELL SIGNAL. 24, 11, p. 2095-2101 11.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. H2S preconditioning of human adipose tissue-derived stem cells increases their efficacy in an in vitro model of cell therapy for simulated ischemia

    Dongó, E., Benkő, Z., Csizmazia, Á., Marosi, G., Grottke, A., Jücker, M., Schumacher, U. & Kiss, L., 15.09.2014, In: LIFE SCI. 113, 1-2, p. 14-21 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia

    Ecker, V., Stumpf, M., Brandmeier, L., Neumayer, T., Pfeuffer, L., Engleitner, T., Ringshausen, I., Nelson, N., Jücker, M., Wanninger, S., Zenz, T., Wendtner, C., Manske, K., Steiger, K., Rad, R., Müschen, M., Ruland, J. & Buchner, M., 10.06.2021, In: NAT COMMUN. 12, 1, p. 3526

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies

    Ehm, P., Nalaskowski, M. M., Wundenberg, T. & Jücker, M., 03.2015, In: NUCLEUS-PHILA. 6, 2, p. 154-64 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins

    Ehm, P. A. H., Lange, F., Hentschel, C., Jepsen, A., Glück, M., Nelson, N., Bettin, B., de Bruyn Kops, C., Kirchmair, J., Nalaskowski, M. & Jücker, M., 11.2019, In: CELL SIGNAL. 63, p. 109380

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. Investigation of the function of the PI3-Kinase / AKT signaling pathway for leukemogenesis and therapy of acute childhood lymphoblastic leukemia (ALL)

    Ehm, P., Grottke, A., Bettin, B. & Jücker, M., 05.2022, In: CELL SIGNAL. 93, 110301.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Reduced expression and activity of patient-derived SHIP1 phosphatase domain mutants

    Ehm, P., Nelson, N., Giehler, S., Schaks, M., Bettin, B., Kirchmair, J. & Jücker, M., 01.2023, In: CELL SIGNAL. 101, 110485.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases

    Ehm, P. A. H., Linnebacher, M., Block, A., Rehbach, C. & Jücker, M., 08.2023, In: CELL SIGNAL. 108, p. 110720

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model

    Ehm, P., Rietow, R., Wegner, W., Bußmann, L., Kriegs, M., Dierck, K., Horn, S., Streichert, T., Horstmann, M. & Jücker, M., 06.07.2023, In: CELLS-BASEL. 12, 13, p. 1798

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. Activated Src kinases downstream of BCR-ABL and Flt3 induces proteasomal degradation of SHIP1 by phosphorylation of tyrosine 1021

    Ehm, P., Bettin, B. & Jücker, M., 06.2023, In: BBA-MOL CELL RES. 1870, 5, 119467.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer

    Elakad, O., Häupl, B., Labitzky, V., Yao, S., Küffer, S., von Hammerstein-Equord, A., Danner, B. C., Jücker, M., Urlaub, H., Lange, T., Ströbel, P., Oellerich, T. & Bohnenberger, H., 19.07.2022, In: NPJ PRECIS ONCOL. 6, 1, 52.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma

    Ewald, F., Grabinski, N., Grottke, A., Windhorst, S., Nörz, D., Carstensen, L., Staufer, K., Hofmann, B. T., Diehl, F., David, K., Schumacher, U., Nashan, B. & Jücker, M., 01.11.2013, In: INT J CANCER. 133, 9, p. 2065-76 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors

    Ewald, F., Nörz, D., Grottke, A., Hofmann, B. T., Nashan, B. & Jücker, M., 2014, In: INVEST NEW DRUG. 32, 6, p. 1144-54 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma

    Ewald, F., Nörz, D., Grottke, A., Bach, J., Herzberger, C., Hofmann, B. T., Nashan, B. & Jücker, M., 2015, In: J CANCER. 6, 12, p. 1195-205 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. Hierarchy of stroma-derived factors in supporting growth of stroma-dependent hemopoietic cells membrane-bound SCF is sufficient to confer stroma competence to epithelial cells

    Friel, J., Itoh, K., Bergholz, U., Jücker, M., Stocking, C., Harrison, P. & Ostertag, W., 01.03.2002, In: GROWTH FACTORS. 20, 1, p. 35-51 17 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3

    Geißert, R., Lammert, A., Wirth, S., Hönig, R., Lohfink, D., Unger, M., Pek, D., Schlüter, K., Scheftschik, T., Smit, D. J., Jücker, M., Menke, A. & Giehl, K., 30.01.2024, In: CELL COMMUN SIGNAL. 22, 1, p. 85

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo

    Genduso, S., Freytag, V., Schetler, D., Kirchner, L., Schiecke, A., Maar, H., Wicklein, D., Gebauer, F., Bröker, K., Stürken, C., Milde-Langosch, K., Oliveira-Ferrer, L., Ricklefs, F. L., Ewald, F., Wolters-Eisfeld, G., Riecken, K., Unrau, L., Krause, L., Bohnenberger, H., Offermann, A., Perner, S., Sebens, S., Lamszus, K., Diehl, L., Linder, S., Jücker, M., Schumacher, U. & Lange, T., 17.03.2023, In: J HEMATOL ONCOL. 16, 1, 23.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. JAK2-V617F is a negative regulation factor of SHIP1 protein and thus influences the AKT signaling pathway in patients with Myeloproliferative Neoplasm (MPN)

    Glück, M., Dally, L., Jücker, M. & Ehm, P., 08.2022, In: INT J BIOCHEM CELL B. 149, 106229.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells.

    Grabinski, N., Ewald, F., Hofmann, B. T., Staufer, K., Schumacher, U., Nashan, B. & Jücker, M., 2012, In: MOL CANCER. 11, p. 85

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells

    Grabinski, N., Bartkowiak, K., Grupp, K., Brandt, B., Pantel, K. & Jücker, M., 12.2011, In: CELL SIGNAL. 23, 12, p. 1952-1960 9 p., 12.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. AKT3 regulates ErbB2, ErbB3 and estrogen receptor α expression and contributes to endocrine therapy resistance of ErbB2(+) breast tumor cells from Balb-neuT mice

    Grabinski, N., Möllmann, K., Milde-Langosch, K., Müller, V., Schumacher, U., Brandt, B., Pantel, K. & Jücker, M., 01.05.2014, In: CELL SIGNAL. 26, 5, p. 1021-9 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4

    Grottke, A., Ewald, F., Lange, T., Nörz, D., Herzberger, C., Bach, J., Grabinski, N., Gräser, L., Höppner, F., Nashan, B., Schumacher, U. & Jücker, M., 2016, In: PLOS ONE. 11, 1, p. e0146370

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. Distinct functions of AKT isoforms in breast cancer: a comprehensive review

    Hinz, N. & Jücker, M., 21.11.2019, In: CELL COMMUN SIGNAL. 17, 1, p. 154

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  25. Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis

    Hinz, N., Baranowsky, A., Horn, M., Kriegs, M., Sibbertsen, F., Smit, D. J., Clezardin, P., Lange, T., Schinke, T. & Jücker, M., 18.02.2021, In: CELLS-BASEL. 10, 2, 430.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. AKT in Bone Metastasis of Solid Tumors: A Comprehensive Review

    Hinz, N. & Jücker, M., 11.05.2021, In: CANCERS. 13, 10, p. 2287

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  27. Activation of PI3K/Akt signaling by n-terminal SH2 domain mutants of the p85α regulatory subunit of PI3K is enhanced by deletion of its c-terminal SH2 domain.

    Hofmann, B. T. & Jücker, M., 2012, In: CELL SIGNAL. 24, 10, p. 1950-1954 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. Posttranscriptional regulation of the p85α adapter subunit of phosphatidylinositol 3-kinase in human leukemia cells

    Hofmann, B. T., Hoxha, E., Mohr, E., Schulz, K. & Jücker, M., 01.03.2011, In: LEUKEMIA LYMPHOMA. 52, 3, p. 467-477 11 p., 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer

    Hofmann, B. T., Schlüter, L., Lange, P., Mercanoglu, B., Ewald, F., Fölster, A., Picksak, A-S., Harder, S., El Gammal, A. T., Grupp, K., Güngör, C., Drenckhan, A., Schlüter, H., Wagener, C., Izbicki, J. R., Jücker, M., Bockhorn, M. & Wolters-Eisfeld, G., 01.01.2015, In: MOL CANCER. 14, 1, p. 109

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. Truncated O-GalNAc glycans impact on fundamental signaling pathways in pancreatic cancer

    Hofmann, B. T., Picksak, A-S., Kwiatkowski, M., Grupp, K., Jücker, M., Bachmann, K., Mercanoglu, B., Izbicki, J. R., Kahlert, C., Bockhorn, M., Güngör, C., Ewald, F. & Wolters-Eisfeld, G., 18.08.2021, In: GLYCOBIOLOGY. 2021, cwab088.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression

    Hohensee, I., Chuang, H-N., Grottke, A., Werner, S., Schulte, A., Horn, S., Lamszus, K., Bartkowiak, K., Witzel, I., Westphal, M., Matschke, J., Glatzel, M., Jücker, M., Pukrop, T., Pantel, K. & Wikman, H., 01.2017, In: ONCOTARGET. 8, 4, p. 6155-6168

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells

    Holler, M., Grottke, A., Mueck, K., Manes, J., Jücker, M., Rodemann, H. P. & Toulany, M., 2016, In: PLOS ONE. 11, 5, p. e0154745

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells.

    Horn, S., Bergholz, U., Jücker, M., McCubrey, J. A., Trümper, L., Stocking, C. & Bäsecke, J., 2008, In: ONCOGENE. 27, 29, p. 4096-4106 29.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. An increase in the expression and total activity of endogenous p60(c-Src) in several factor-independent mutants of a human GM-CSF-dependent leukemia cell line (TF-1)

    Horn, S., Meyer, J., Stocking, C., Ostertag, W. & Jücker, M., 16.10.2003, In: ONCOGENE. 22, 46, p. 7170-80 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. The inositol 5-phosphatase SHIP is expressed as 145 and 135 kDa proteins in blood and bone marrow cells in vivo, whereas carboxyl-truncated forms of SHIP are generated by proteolytic cleavage in vitro

    Horn, S., Meyer, J., Heukeshoven, J., Fehse, B., Schulze, C., Li, S., Frey, J., Poll, S., Stocking, C. & Jücker, M., 01.2001, In: LEUKEMIA. 15, 1, p. 112-20 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  36. Expression of the neural adhesion molecule L1 in the deafferented dentate gyrus

    Jucker, M., D'Amato, F., Mondadori, C., Mohajeri, H., Magyar, J., Bartsch, U. & Schachner, M., 12.1996, In: NEUROSCIENCE. 75, 3, p. 703-15 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts

    Kebenko, M., Drenckhan, A., Gros, S. J., Jücker, M., Grabinski, N., Ewald, F., Grottke, A., Schultze, A., Izbicki, J. R., Bokemeyer, C., Wellbrock, J. & Fiedler, W., 01.02.2015, In: CELL SIGNAL. 27, 2, p. 373-81 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  38. Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis

    Kempska, J., Oliveira-Ferrer, L., Grottke, A., Qi, M., Alawi, M., Meyer, F., Borgmann, K., Hamester, F., Eylmann, K., Rossberg, M., Smit, D. J., Jücker, M., Laakmann, E., Witzel, I., Schmalfeldt, B., Müller, V. & Legler, K., 06.07.2023, In: FRONT ONCOL. 13, p. 1129682 1129682.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  39. Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity

    Koch, C., Kuske, A., Joosse, S. A., Yigit, G., Sflomos, G., Thaler, S., Smit, D. J., Werner, S., Borgmann, K., Gärtner, S., Mossahebi Mohammadi, P., Battista, L., Cayrefourcq, L., Altmüller, J., Salinas-Riester, G., Raithatha, K., Zibat, A., Goy, Y., Ott, L., Bartkowiak, K., Tan, T. Z., Zhou, Q., Speicher, M. R., Müller, V., Gorges, T. M., Jücker, M., Thiery, J-P., Brisken, C., Riethdorf, S., Alix-Panabières, C. & Pantel, K., 07.09.2020, In: EMBO MOL MED. 12, 9, e11908.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice

    Labitzky, V., Baranowsky, A., Maar, H., Hanika, S., Starzonek, S., Ahlers, A-K., Stübke, K., Koziolek, E. J., Heine, M., Schäfer, P., Windhorst, S., Jücker, M., Riecken, K., Amling, M., Schinke, T., Schumacher, U., Valentiner, U. & Lange, T., 07.02.2020, In: CANCERS. 12, 2

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  41. Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia

    Latuske, E-M., Stamm, H., Klokow, M., Vohwinkel, G., Muschhammer, J., Bokemeyer, C., Jücker, M., Kebenko, M., Fiedler, W. & Wellbrock, J., 25.04.2017, In: ONCOTARGET. 8, 17, p. 29187-29201

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. Akt isoform specific effects in ovarian cancer progression

    Linnerth-Petrik, N. M., Santry, L. A., Moorehead, R., Jücker, M., Wootton, S. K. & Petrik, J., 15.11.2016, In: ONCOTARGET. 7, 46, p. 74820-74833 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer

    Marquard, F. E. & Jücker, M., 02.2020, In: BIOCHEM PHARMACOL. 172, p. 113729

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  44. Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.

    Metzner, A., Horstmann, M., Fehse, B., Ortmeyer, G., Niemeyer, C. M., Stocking, C., Mayr, G. W. & Jücker, M., 2007, In: GENE THER. 14, 8, p. 699-703 8.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D.

    Metzner, A., Precht, C., Fehse, B., Fiedler, W., Stocking, C., Günther, A., Mayr, G. W. & Jücker, M., 2009, In: GENE THER. 16, 4, p. 570-573 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM+ and CD90+ Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model

    Moustafa, M., Dähling, K-K., Günther, A., Riebandt, L., Smit, D. J., Riecken, K., Schröder, C., Zhuang, R., Krech, T., Kriegs, M., Fehse, B., Izbicki, J., Fischer, L., Nashan, B., Li, J. & Jücker, M., 08.04.2022, In: CANCERS. 14, 8, 1882.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. The inositol 5-phosphatase SHIP1 is a nucleo-cytoplasmic shuttling protein and enzymatically active in cell nuclei.

    Nalaskowski, M., Metzner, A., Brehm, M., Labiadh, S., Brauer, H., Grabinski, N., Mayr, G. W. & Jücker, M., 2012, In: CELL SIGNAL. 24, 3, p. 621-628 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  48. Nuclear accumulation of SHIP1 mutants derived from AML patients leads to increased proliferation of leukemic cells

    Nalaskowski, M. M., Ehm, P., Rehbach, C., Nelson, N., Täger, M., Modest, K. & Jücker, M., 09.2018, In: CELL SIGNAL. 49, p. 87-94 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. Characterization of the substrate specificity of the inositol 5-phosphatase SHIP1

    Nelson, N., Wundenberg, T., Lin, H., Rehbach, C., Horn, S., Windhorst, S. & Jücker, M., 02.04.2020, In: BIOCHEM BIOPH RES CO. 524, 2, p. 366-370 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  50. AKT1 and PTEN show the highest affinities among phosphoinositide binding proteins for the second messengers PtdIns(3,4,5)P3 and PtdIns(3,4)P2

    Nelson, N., Razeto, A., Gilardi, A., Grättinger, M., Kirchmair, J. & Jücker, M., 03.09.2021, In: BIOCHEM BIOPH RES CO. 568, p. 110-115 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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