Research ExplorerScientific StaffJörg Heeren Publications

Prof. Dr. ID: 59947

Jörg Heeren

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Affiliations
101 - 150 out of 169Page size: 50

Publications

  1. 2015

  2. Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control

    Klünder, S., Heeren, J., Markmann, S., Santer, R., Braulke, T. & Pohl, S., 08.2015, In: J LIPID RES. 56, 8, p. 1625-32 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice

    Baumeier, C., Kaiser, D., Heeren, J., Scheja, L., John, C., Weise, C., Eravci, M., Lagerpusch, M., Schulze, G., Joost, H-G., Schwenk, R. W. & Schürmann, A., 05.2015, In: Biochim Biophys Acta. 1851, 5, p. 566-76 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

    Hoffmann, L. S., Etzrodt, J., Willkomm, L., Sanyal, A., Scheja, L., Fischer, A. W. C., Stasch, J-P., Bloch, W., Friebe, A., Heeren, J. & Pfeifer, A., 05.2015, In: NAT COMMUN. 6, p. Art. 7235

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Lrp1/LDL receptor play critical roles in mannose 6-phosphate-independent lysosomal enzyme targeting

    Markmann, S., Thelen, M., Cornils, K., Schweizer, M., Brocke-Ahmadinejad, N., Willnow, T., Heeren, J., Gieselmann, V., Braulke, T. & Kollmann, K., 18.03.2015, In: TRAFFIC.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

    Carambia, A., Freund, B., Schwinge, D., Bruns, O. T., Salmen, S. C., Ittrich, H., Reimer, R., Heine, M., Huber, S., Waurisch, C., Eychmüller, A., Wraith, D. C., Korn, T., Nielsen, P., Weller, H., Schramm, C., Lüth, S., Lohse, A. W., Heeren, J. & Herkel, J., 21.01.2015, In: J HEPATOL. 62, 6, p. 1349-1356

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice

    Bargheer, D., Giemsa, A., Freund, B., Heine, M., Waurisch, C., Stachowski, G. M., Hickey, S. G., Eychmüller, A., Heeren, J. & Nielsen, P., 09.01.2015, In: BEILSTEIN J NANOTECH. 6, p. 111-23 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. The fate of a designed protein corona on nanoparticles in vitro and in vivo

    Bargheer, D., Nielsen, J., Gébel, G., Heine, M., Salmen, S. C., Stauber, R., Weller, H., Heeren, J. & Nielsen, P., 06.01.2015, In: BEILSTEIN J NANOTECH. 6, p. 36-46 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

    Berbée, J. F. P., Boon, M. R., Khedoe, P. P. S. J., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., Jung, C., Vazirpanah, N., Brouwers, L. P. J., Gordts, P. L. S. M., Esko, J. D., Hiemstra, P. S., Havekes, L. M., Scheja, L., Heeren, J. & Rensen, P. C. N., 2015, In: NAT COMMUN. 6, p. 6356

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity

    Wagner, T., Bartelt, A., Schlein, C. & Heeren, J., 2015, In: PLOS ONE. 10, 12, e0145102.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. 2014

  12. Synthesis of radioactively labelled CdSe/CdS/ZnS quantum dots for in vivo experiments

    Stachowski, G. M., Bauer, C., Waurisch, C., Bargheer, D., Nielsen, P., Heeren, J., Hickey, S. G. & Eychmüller, A., 10.12.2014, In: BEILSTEIN J NANOTECH. 5, p. 2383-2387 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids

    John, C., Werner, P., Worthmann, A., Wegner, K., Tödter, K., Scheja, L., Rohn, S., Heeren, J. & Fischer, M., 05.12.2014, In: J CHROMATOGR A. 1371, p. 184-195 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. High density lipoprotein metabolism in low density lipoprotein receptor-deficient mice

    Rinninger, F., Heine, M., Singaraja, R., Hayden, M., Brundert, M., Ramakrishnan, R. & Heeren, J., 01.09.2014, In: J LIPID RES. 55, 9, p. 1914-1924 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. TGF-β-dependent induction of CD4⁺CD25⁺Foxp3⁺ Tregs by liver sinusoidal endothelial cells

    Carambia, A., Freund, B., Schwinge, D., Heine, M., Laschtowitz, A., Huber, S., Wraith, D. C., Korn, T., Schramm, C., Lohse, A. W., Heeren, J. & Herkel, J., 01.09.2014, In: J HEPATOL. 61, 3, p. 594-9 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. Dichloroacetate prevents restenosis in preclinical animal models of vessel injury

    Deuse, T., Hua, X., Wang, D., Maegdefessel, L., Heeren, J., Scheja, L., Bolaños, J. P., Rakovic, A., Spin, J. M., Stubbendorff, M., Ikeno, F., Länger, F., Zeller, T., Schulte-Uentrop, L., Stoehr, A., Itagaki, R., Haddad, F., Eschenhagen, T., Blankenberg, S., Kiefmann, R., Reichenspurner, H., Velden, J., Klein, C., Yeung, A., Robbins, R. C., Tsao, P. S. & Schrepfer, S., 29.05.2014, In: NATURE. 509, 7502, p. 641-644 4 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries

    Reverter, M., Rentero, C., Garcia-Melero, A., Hoque, M., Vilà de Muga, S., Alvarez-Guaita, A., Conway, J. R. W., Wood, P., Cairns, R., Lykopoulou, L., Grinberg, D., Vilageliu, L., Bosch, M., Heeren, J., Blasi, J., Timpson, P., Pol, A., Tebar, F., Murray, R. Z., Grewal, T. & Enrich, C., 08.05.2014, In: CELL REP. 7, 3, p. 883-897 15 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity

    Bartelt, A., Beil, T., Müller, B., Koehne, T., Yorgan, T. A., Heine, M., Yilmaz, T., Ruether, W., Heeren, J., Schinke, T. & Niemeier, A., 01.05.2014, In: BONE. 62, p. 90-98 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism

    Oehler, N., Volz, T., Bhadra, O. D., Kah, J., Allweiss, L., Giersch, K., Bierwolf, J., Riecken, K., Pollok, J. M., Lohse, A. W., Fehse, B., Petersen, J., Urban, S., Lütgehetmann, M., Heeren, J. & Dandri, M., 08.04.2014, In: HEPATOLOGY.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant

    Albers, K., Schlein, C., Wenner, K., Lohse, P., Bartelt, A., Heeren, J., Santer, R. & Merkel, M., 01.03.2014, In: ATHEROSCLEROSIS. 233, 1, p. 97-103 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Intraperitoneal Injection Improves the Uptake of Nanoparticle-Labeled High-Density Lipoprotein to Atherosclerotic Plaques Compared With Intravenous Injection: A Multimodal Imaging Study in ApoE Knockout Mice

    Jung, C., Kaul, M. G., Bruns, O. T., Dučić, T., Freund, B., Heine, M., Reimer, R., Meents, A., Salmen, S. C., Weller, H., Nielsen, P., Adam, G., Heeren, J. & Ittrich, H., 01.03.2014, In: CIRC-CARDIOVASC IMAG. 7, 2, p. 303-11 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Adipose tissue browning and metabolic health

    Bartelt, A. & Heeren, J., 01.01.2014, In: NAT REV ENDOCRINOL. 10, 1, p. 24-36 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. Selectins mediate small cell lung cancer systemic metastasis

    Heidemann, F., Schildt, A., Schmid, K., Bruns, O. T., Riecken, K., Jung, C., Ittrich, H., Wicklein, D., Reimer, R., Fehse, B., Heeren, J., Lüers, G., Schumacher, U. & Heine, M., 01.01.2014, In: PLOS ONE. 9, 4, p. e92327

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver

    Heine, M., Bartelt, A., Bruns, O. T., Bargheer, D., Giemsa, A., Freund, B., Scheja, L., Waurisch, C., Eychmüller, A., Reimer, R., Weller, H., Nielsen, P. & Heeren, J., 01.01.2014, In: BEILSTEIN J NANOTECH. 5, p. 1432-1440 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. 2013

  26. Effects of adipocyte lipoprotein lipase on de novo lipogenesis and white adipose tissue browning

    Bartelt, A., John, C., Cherradi, M. L., Niemeier, A., Tödter, K., Heeren, J. & Scheja, L., 01.05.2013, In: BBA-MOL CELL BIOL L. 1831, 5, p. 934-42 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. Novel aspects of brown adipose tissue biology

    Heeren, J. & Münzberg, H., 01.03.2013, In: ENDOCRIN METAB CLIN. 42, 1, p. 89-107 19 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

    Kornfeld, J-W., Baitzel, C., Könner, A. C., Nicholls, H. T., Vogt, M. C., Herrmanns, K., Scheja, L., Haumaitre, C., Wolf, A. M., Knippschild, U., Seibler, J., Cereghini, S., Heeren, J., Stoffel, M. & Brüning, J. C., 07.02.2013, In: NATURE. 494, 7435, p. 111-5 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. Pharmacological characterization of 1-nitrosocyclohexyl acetate, a long-acting nitroxyl donor that shows vasorelaxant and antiaggregatory effects

    Donzelli, S., Fischer, G., King, B. S., Niemann, C., DuMond, J. F., Heeren, J., Wieboldt, H., Baldus, S., Gerloff, C., Eschenhagen, T., Carrier, L., Böger, R. H. & Espey, M. G., 01.02.2013, In: J PHARMACOL EXP THER. 344, 2, p. 339-47 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain

    Carlo, A-S., Gustafsen, C., Mastrobuoni, G., Nielsen, M. S., Burgert, T., Hartl, D., Rohe, M., Nykjaer, A., Herz, J., Heeren, J., Kempa, S., Petersen, C. M. & Willnow, T. E., 02.01.2013, In: J NEUROSCI. 33, 1, p. 358-70 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

    Eissing, L., Scherer, T., Tödter, K., Knippschild, U., Greve, J. W., Buurman, W. A., Pinnschmidt, H. O., Rensen, S. S., Wolf, A. M., Bartelt, A., Heeren, J., Buettner, C. & Scheja, L., 01.01.2013, In: NAT COMMUN. 4, p. 1528

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Inhibition of mitogen-activated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells

    Mulay, V., Wood, P., Manetsch, M., Darabi, M., Cairns, R., Hoque, M., Chan, K. C., Reverter, M., Alvarez-Guaita, A., Rye, K-A., Rentero, C., Heeren, J., Enrich, C. & Grewal, T., 01.01.2013, In: PLOS ONE. 8, 4, p. e62667

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection

    Helk, E., Bernin, H., Ernst, T., Ittrich, H., Jacobs, T., Heeren, J., Tacke, F., Tannich, E. & Lotter, H., 01.01.2013, In: PLOS PATHOG. 9, 1, p. e1003096

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. Increased expression of transthyretin in leptin-deficient ob/ob mice is not causative for their major phenotypic abnormalities.

    Rendenbach, C., Ganswindt, S., Seitz, S., Barvencik, F., Hübner, A. K., Baranowsky, A., Streichert, T., Niemeier, A., Heeren, J., Amling, M., Bartelt, A. & Schinke, T., 2013, In: J NEUROENDOCRINOL. 25, 1, p. 14-22 9 p., 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. 2012

  36. A new, powerful player in lipoprotein metabolism: brown adipose tissue.

    Bartelt, A., Merkel, M. & Heeren, J., 2012, In: J MOL MED. 90, 8, p. 887-893 8.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. A simple and widely applicable method to 59Fe-radiolabel monodisperse superparamagnetic iron oxide nanoparticles for in vivo quantification studies.

    Freund, B., Tromsdorf, U. I., Bruns, O. T., Heine, M., Giemsa, A., Bartelt, A., Salmen, S. C., Raabe, N., Heeren, J., Ittrich, H., Reimer, R., Hohenberg, H., Schumacher, U., Weller, H. & Nielsen, P., 2012, In: ACS NANO. 6, 8, p. 7318-7325 8.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  38. Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice.

    Gordts, P. L. S. M., Bartelt, A., Nilsson, S. K., Annaert, W., Christoffersen, C., Nielsen, L. B., Heeren, J. & Roebroek, A. J. M., 2012, In: PLOS ONE. 7, 6, p. 38330 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  39. Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E.

    Laatsch, A., Panteli, M., Sornsakrin, M., Hoffzimmer, B., Grewal, T. & Heeren, J., 2012, In: PLOS ONE. 7, 1, p. 29385 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.

    Makrypidi, G., Damme, M., Müller-Loennies, S., Trusch, M., Schmidt, B., Schlüter, H., Heeren, J., Lübke, T., Saftig, P. & Braulke, T., 2012, In: MOL CELL BIOL. 32, 4, p. 774-782 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  41. Nanocrystals, a new tool to study lipoprotein metabolism and atherosclerosis.

    Heeren, J. & Bruns, O., 2012, In: CURR PHARM BIOTECHNO. 13, 2, p. 365-372 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.

    van Rahden, V., Brand, K., Najm, J., Heeren, J., Heeren, J., Braulke, T., Kutsche, K. & Kutsche, K., 2012, In: HUM MOL GENET. 21, 23, p. 5019-5038 23.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.

    Jaschke, A., Chung, B., Hesse, D., Kluge, R., Zahn, C., Moser, M., Petzke, K-J., Brigelius-Flohé, R., Puchkov, D., Koepsell, H., Heeren, J., Joost, H-G. & Schürmann, A., 2012, In: HUM MOL GENET. 21, 14, p. 3128-3142 14.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. The holy grail of metabolic disease: brown adipose tissue.

    Bartelt, A. & Heeren, J., 2012, In: CURR OPIN LIPIDOL. 23, 3, p. 190-195 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. The role of apolipoprotein E in bone metabolism.

    Niemeier, A., Schinke, T., Heeren, J. & Amling, M., 2012, In: BONE. 50, 2, p. 518-524 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. Triacylglycerol-rich lipoproteins protect lipoprotein lipase from inactivation by ANGPTL3 and ANGPTL4.

    Nilsson, S. K., Anderson, F., Ericsson, M., Larsson, M., Makoveichuk, E., Lookene, A., Heeren, J. & Olivecrona, G., 2012, In: Biochim Biophys Acta. 1821, 10, p. 1370-1378 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. 2011

  48. Altered endocannabinoid signalling after a high-fat diet in Apoe(-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance.

    Bartelt, A., Orlando, P., Mele, C., Ligresti, A., Tödter, K., Scheja, L., Heeren, J. & Di Marzo, V., 2011, In: DIABETOLOGIA. 54, 11, p. 2900-2910 11.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. Apolipoprotein A-V; a potent triglyceride reducer.

    Nilsson, S. K., Heeren, J., Olivecrona, G. & Merkel, M., 2011, In: ATHEROSCLEROSIS. 219, 1, p. 15-21 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  50. Brown adipose tissue activity controls triglyceride clearance.

    Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M., Tromsdorf, U. I., Weller, H., Waurisch, C., Eychmüller, A., Gordts, P. L. S. M., Rinninger, F., Brügelmann, K., Freund, B., Nielsen, P., Merkel, M. & Heeren, J., 2011, In: NAT MED. 17, 2, p. 200-205 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  51. [Energy, brown adipose tissue, obesity].

    Merkel, M. & Heeren, J., 2011, In: DEUT MED WOCHENSCHR. 136, 11, p. 548-550 11.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  52. PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication.

    Cuchet, D., Sykes, A., Nicolas, A., Orr, A., Murray, J., Sirma, H., Heeren, J., Bartelt, A. & Everett, R. D., 2011, In: J CELL SCI. 124, 2, p. 280-291 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  53. Ras/mitogen-activated protein kinase (MAPK) signaling modulates protein stability and cell surface expression of scavenger receptor SR-BI.

    Wood, P., Mulay, V., Darabi, M., Chan, K. C., Heeren, J., Pol, A., Lambert, G., Rye, K-A., Enrich, C. & Grewal, T., 2011, In: J BIOL CHEM. 286, 26, p. 23077-23092 26.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  54. Role for LAMP-2 in endosomal cholesterol transport.

    Schneede, A., Schmidt, C. K., Hölttä-Vuori, M., Heeren, J., Willenborg, M., Blanz, J., Domanskyy, M., Breiden, B., Brodesser, S., Landgrebe, J., Sandhoff, K., Ikonen, E., Saftig, P. & Eskelinen, E-L., 2011, In: J CELL MOL MED. 15, 2, p. 280-295 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  55. Scavenger receptor CD36 mediates uptake of high density lipoproteins in mice and by cultured cells.

    Brundert, M., Heeren, J., Merkel, M., Carambia, A., Herkel, J., Groitl, P., Dobner, T., Ramakrishnan, R., Moore, K. J. & Rinninger, F., 2011, In: J LIPID RES. 52, 4, p. 745-758 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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