During the last decades, obesity research has focused on food intake regulation, whereas energy expenditure has been mainly measured based on whole-body oxygen consumption. With the renaissance of brown adipose tissue (BAT) thermogenesis as a potential drug target in humans, more thought is put into alternative heat-producing mechanisms. Also, the interaction of peripheral and central components to regulate thermogenesis requires further studies. Certainly, several of the novel molecular genetic tools available now, compared with 40 years ago, will be helpful to gain new insights in BAT-controlled energy homeostasis and promises new approaches to pharmacologically control body weight.
