Novel aspects of brown adipose tissue biology
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Novel aspects of brown adipose tissue biology. / Heeren, Joerg; Münzberg, Heike.
In: ENDOCRIN METAB CLIN, Vol. 42, No. 1, 01.03.2013, p. 89-107.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Novel aspects of brown adipose tissue biology
AU - Heeren, Joerg
AU - Münzberg, Heike
N1 - Copyright © 2013 Elsevier Inc. All rights reserved.
PY - 2013/3/1
Y1 - 2013/3/1
N2 - During the last decades, obesity research has focused on food intake regulation, whereas energy expenditure has been mainly measured based on whole-body oxygen consumption. With the renaissance of brown adipose tissue (BAT) thermogenesis as a potential drug target in humans, more thought is put into alternative heat-producing mechanisms. Also, the interaction of peripheral and central components to regulate thermogenesis requires further studies. Certainly, several of the novel molecular genetic tools available now, compared with 40 years ago, will be helpful to gain new insights in BAT-controlled energy homeostasis and promises new approaches to pharmacologically control body weight.
AB - During the last decades, obesity research has focused on food intake regulation, whereas energy expenditure has been mainly measured based on whole-body oxygen consumption. With the renaissance of brown adipose tissue (BAT) thermogenesis as a potential drug target in humans, more thought is put into alternative heat-producing mechanisms. Also, the interaction of peripheral and central components to regulate thermogenesis requires further studies. Certainly, several of the novel molecular genetic tools available now, compared with 40 years ago, will be helpful to gain new insights in BAT-controlled energy homeostasis and promises new approaches to pharmacologically control body weight.
KW - Adipocytes
KW - Adipose Tissue, Brown
KW - Adipose Tissue, White
KW - Animals
KW - Body Temperature Regulation
KW - Energy Metabolism
KW - Humans
KW - Thermogenesis
U2 - 10.1016/j.ecl.2012.11.004
DO - 10.1016/j.ecl.2012.11.004
M3 - SCORING: Journal article
C2 - 23391242
VL - 42
SP - 89
EP - 107
JO - ENDOCRIN METAB CLIN
JF - ENDOCRIN METAB CLIN
SN - 0889-8529
IS - 1
ER -