Research ExplorerScientific StaffSabine Windhorst Publications

PD.Dr. ID: 48363

Sabine Windhorst

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  1. 2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: identification of a new and potent inhibitor

    Löhndorf, A., Hosang, L., Dohle, W., Odoardi, F., Waschkowski, S-A., Rosche, A., Bauche, A., Winzer, R., Tolosa, E., Windhorst, S., Marry, S., Flügel, A., Potter, B. V. L., Diercks, B-P. & Guse, A. H., 05.2021, In: BBA-MOL CELL RES. 1868, 6, p. 118988

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  2. Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase.

    Mayr, G. W., Windhorst, S. & Hillemeier, K., 2005, In: J BIOL CHEM. 280, 14, p. 13229-13240 14.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5

    Riley, A. M., Windhorst, S., Lin, H. & Potter, B. V. L., 03.01.2014, In: CHEMBIOCHEM. 15, 1, p. 57-67 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. Characterization of the substrate specificity of the inositol 5-phosphatase SHIP1

    Nelson, N., Wundenberg, T., Lin, H., Rehbach, C., Horn, S., Windhorst, S. & Jücker, M., 02.04.2020, In: BIOCHEM BIOPH RES CO. 524, 2, p. 366-370 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Clinical relevance of cytoskeleton associated proteins for ovarian cancer

    Schiewek, J., Schumacher, U., Lange, T., Joosse, S. A., Wikman, H., Pantel, K., Mikhaylova, M., Kneussel, M., Linder, S., Schmalfeldt, B., Oliveira-Ferrer, L. & Windhorst, S., 11.2018, In: J CANCER RES CLIN. 144, 11, p. 2195-2205 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma

    Ewald, F., Grabinski, N., Grottke, A., Windhorst, S., Nörz, D., Carstensen, L., Staufer, K., Hofmann, B. T., Diehl, F., David, K., Schumacher, U., Nashan, B. & Jücker, M., 01.11.2013, In: INT J CANCER. 133, 9, p. 2065-76 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. Conserved Tao Kinase Activity Regulates Dendritic Arborization, Cytoskeletal Dynamics, and Sensory Function in Drosophila

    Hu, C., Kanellopoulos, A. K., Richter, M., Petersen, M., Konietzny, A., Tenedini, F. M., Hoyer, N., Cheng, L., Poon, C. L. C., Harvey, K. F., Windhorst, S., Parrish, J. Z., Mikhaylova, M., Bagni, C., Calderon de Anda, F. & Soba, P., 26.02.2020, In: J NEUROSCI. 40, 9, p. 1819-1833 15 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Control of aromatase in hippocampal neurons

    Fester, L., Brandt, N., Windhorst, S., Pröls, F., Bläute, C. & Rune, G. M., 01.06.2016, In: J STEROID BIOCHEM. 160, p. 9-14

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Cryo-EM structures of actin binding proteins as tool for drug discovery

    Dahlstroem, C., Paraschiakos, T., Sun, H. & Windhorst, S., 08.2023, In: BIOCHEM PHARMACOL. 214, p. 115680

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  10. DIAPH1 facilitates paclitaxel-mediated cytotoxicity of ovarian cancer cells

    Flat, W., Borowski, S., Paraschiakos, T., Blechner, C. & Windhorst, S., 03.2022, In: BIOCHEM PHARMACOL. 197, 114898.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. DIAPH1 regulates chromosomal instability of cancer cells by controlling microtubule dynamics

    Miao, S., Schäfer, P., Nojszewski, J., Meyer, F. & Windhorst, S., 04.2021, In: EUR J CELL BIOL. 100, 3, 151156.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. Diaphanous-related formin 1 as a target for tumor therapy

    Lin, Y-N. & Windhorst, S., 15.10.2016, In: BIOCHEM SOC T. 44, 5, p. 1289-1293 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Differential Proteome Analysis of Human Neuroblastoma Xenograft Primary Tumors and Matched Spontaneous Distant Metastases

    Hänel, L., Gosau, T., Maar, H., Valentiner, U., Schumacher, U., Riecken, K., Windhorst, S., Hansen, N-O., Heikaus, L., Wurlitzer, M., Nolte, I., Schlüter, H. & Lange, T., 09.2018, In: SCI REP-UK. 8, 1, p. 13986

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion

    Lin, Y-N., Bhuwania, R., Gromova, K., Failla, A. V., Lange, T., Riecken, K., Linder, S., Kneussel, M., Izbicki, J. R. & Windhorst, S., 30.07.2015, In: ONCOTARGET. 6, 21, p. 18577-89 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells

    Bäder, S., Glaubke, E., Grüb, S., Muhs, S., Wellbrock, J., Nalaskowski, M., Lange, T. & Windhorst, S., 26.06.2018, In: BIOCHEM J. 475, 12, p. 2057-2071 15 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. Expression of DIAPH1 is up-regulated in colorectal cancer and its down-regulation strongly reduces the metastatic capacity of colon carcinoma cells

    Lin, Y-N., Izbicki, J. R., König, A., Habermann, J. K., Blechner, C., Lange, T., Schumacher, U. & Windhorst, S., 01.04.2014, In: INT J CANCER. 134, 7, p. 1571-82 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. Expression, Purification and preliminary X-Ray diffraction of a pathogenic bacterial protease from Stenotrophomonas maltophilia

    Negm, A., Windhorst, S., Betzel, C., Akrem, A. & Weber, W., 2014, In: World J Pharm Pharm Sci. 3, 10, p. 13-23

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.

    Chang, L., Schwarzenbach, H., Meyer-Staeckling, S., Brandt, B., Mayr, G. W., Weitzel, J. M. & Windhorst, S., 2013, In: MOL CANCER RES.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Ex vivo aorta patch model for analysis of cellular adhesion

    Lin, Y-N., Thata, R. N., Failla, A. V., Geissen, M., Daum, G. & Windhorst, S., 06.2015, In: TISSUE CELL. 47, 3, p. 266-272 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. Ex Vivo Model of Neuroblastoma Plasticity

    Schäfer, P., Muhs, S., Turnbull, L., Garwal, P., Maar, H., Yorgan, T. A., Tolosa, E., Lange, T. & Windhorst, S., 17.02.2023, In: CANCERS. 15, 4, 1274.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.

    Windhorst, S., Kalinina, T., Schmid, K., Blechner, C., Kriebitzsch, N., Hinsch, R., Chang, L., Herich, L., Schumacher, U. & Mayr, G. W., 2011, In: INT J CANCER. 129, 6, p. 1300-1309 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.

    Nalaskowski, M., Fliegert, R., Ernst, O., Brehm, M., Fanick, W., Windhorst, S., Lin, H., Giehler, S., Hein, J., Lin, Y-N. & Mayr, G. W., 2011, In: J BIOL CHEM. 286, 6, p. 4500-4510 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A

    Schröder, D., Rehbach, C., Seyffarth, C., Neuenschwander, M., Kries, J. V. & Windhorst, S., 20.09.2013, In: BIOCHEM BIOPH RES CO. 439, 2, p. 228-34 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines

    Köster, J-D., Leggewie, B., Blechner, C., Brandt, N., Fester, L., Rune, G., Schweizer, M., Kindler, S. & Windhorst, S., 01.2016, In: CELL SIGNAL. 28, 1, p. 83-90 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. Inositol-1,4,5-trisphosphate-3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumour cells by two functional activities.

    Windhorst, S., Fliegert, R., Blechner, C., Möllmann, K., Hosseini, Z., Guenther, T., Eiben, M., Chang, L., Lin, H., Fanick, W., Schumacher, U., Brandt, B. & Mayr, G. W., 2010, In: J BIOL CHEM. 285, 8, p. 5541-5554 8.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types

    Windhorst, S., Song, K. & Gazdar, A. F., 01.08.2017, In: BIOCHEM PHARMACOL. 137, p. 1-9 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  27. Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients.

    Windhorst, S., Minge, D., Bähring, R., Hüser, S., Schob, C., Blechner, C., Lin, H., Mayr, G. W. & Kindler, S., 2012, In: CELL SIGNAL. 24, 3, p. 750-757 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. Inositol hexakisphosphate increases the size of platelet aggregates

    Brehm, M. A., Klemm, U., Rehbach, C., Erdmann, N., Kolšek, K., Lin, H., Aponte-Santamaría, C., Gräter, F., Rauch, B. H., Riley, A. M., Mayr, G. W., Potter, B. V. L. & Windhorst, S., 03.2019, In: BIOCHEM PHARMACOL. 161, p. 14-25 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.

    Windhorst, S., Blechner, C., Lin, H., Elling, C., Nalaskowski, M., Kirchberger, T., Guse, A. H. & Mayr, G. W., 2008, In: BIOCHEM J. 414, 3, p. 407-417 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase.

    Brehm, M. A., Schenk, T. M. H., Zhou, X., Fanick, W., Lin, H., Windhorst, S., Nalaskowski, M., Kobras, M., Shears, S. B. & Mayr, G. W., 2007, In: BIOCHEM J. 408, 3, p. 335-345 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. Key Role of Hyaluronan Metabolism for the Development of Brain Metastases in Triple-Negative Breast Cancer

    Hamester, F., Stürken, C., Legler, K., Eylmann, K., Möller, K., Roßberg, M., Gorzelanny, C., Bauer, A. T., Windhorst, S., Schmalfeldt, B., Laakmann, E., Müller, V., Witzel, I. & Oliveira-Ferrer, L., 18.10.2022, In: CELLS-BASEL. 11, 20, 3275.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Malignant H1299 tumour cells preferentially internalize iron-bound inositol hexakisphosphate

    Helmis, C., Blechner, C., Lin, H., Schweizer, M., Mayr, G. W., Nielsen, P. & Windhorst, S., 01.01.2013, In: BIOSCIENCE REP. 33, 5

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. Mechanism of BIP-4 mediated inhibition of InsP3Kinase-A

    Paraschiakos, T., Flat, W., Chen, Y., Kirchmair, J. & Windhorst, S., 30.07.2021, In: BIOSCIENCE REP. 41, 7, BSR20211259.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. Mice lacking plastin-3 display a specific defect of cortical bone acquisition

    Yorgan, T., Sari, H., Rolvien, T., Windhorst, S., Failla, A. V., Kornak, U., Oheim, R., Amling, M. & Schinke, T., 01.2020, In: BONE. 130, p. 115062

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. Microtubules Modulate F-actin Dynamics during Neuronal Polarization

    Zhao, B., Meka, P., Scharrenberg, R., König, T., Schwanke, B., Kobler, O., Windhorst, S., Kreutz, M. R., Mikhaylova, M. & Calderon de Anda, F., 29.08.2017, In: SCI REP-UK. 7, 1, p. 9583

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  36. Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice

    Labitzky, V., Baranowsky, A., Maar, H., Hanika, S., Starzonek, S., Ahlers, A-K., Stübke, K., Koziolek, E. J., Heine, M., Schäfer, P., Windhorst, S., Jücker, M., Riecken, K., Amling, M., Schinke, T., Schumacher, U., Valentiner, U. & Lange, T., 07.02.2020, In: CANCERS. 12, 2

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. New options of cancer treatment employing InsP6

    Brehm, M. A. & Windhorst, S., 05.2019, In: BIOCHEM PHARMACOL. 163, p. 206-214 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  38. Oncogenic activity and cellular functionality of melanoma associated antigen A3

    Schäfer, P., Paraschiakos, T. & Windhorst, S., 10.2021, In: BIOCHEM PHARMACOL. 192, 114700.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  39. Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density

    Middelkamp, M., Ruck, L., Krisp, C., Sumisławski, P., Mohammadi, B., Dottermusch, M., Meister, V., Küster, L., Schlüter, H., Windhorst, S. & Neumann, J. E., 20.11.2021, In: ACTA NEUROPATHOL COM. 9, 1, p. 185

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice

    Blechner, C., Becker, L., Fuchs, H., Rathkolb, B., Prehn, C., Adler, T., Calzada-Wack, J., Garrett, L., Gailus-Durner, V., Morellini, F., Conrad, S., Hölter, S. M., Wolf, E., Klopstock, T., Adamski, J., Busch, D., de Angelis, M. H., Schmeisser, M. J. & Windhorst, S., 14.09.2020, In: NEUROSCI LETT. 735, p. 135206

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  41. Radial somatic F-actin organization affects growth cone dynamics during early neuronal development

    Meka, D. P., Scharrenberg, R., Zhao, B., Kobler, O., König, T., Schaefer, I., Schwanke, B., Klykov, S., Richter, M., Eggert, D., Windhorst, S., Dotti, C. G., Kreutz, M. R., Mikhaylova, M. & Calderon de Anda, F., 05.12.2019, In: EMBO REP. 20, 12, p. e47743

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis.

    Kasten-Pisula, U., Windhorst, S., Dahm-Daphi, J., Mayr, G. W. & Dikomey, E., 2007, In: RADIOTHER ONCOL. 83, 3, p. 296-303 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity

    Chen, L., DeWispelaere, A., Dastvan, F., Osborne, W. R. A., Blechner, C., Windhorst, S. & Daum, G., 2016, In: PLOS ONE. 11, 5, p. e0155726

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. Strong fascin expression promotes metastasis independent of its F-actin bundling activity

    Heinz, L. S., Muhs, S., Schiewek, J., Grüb, S., Nalaskowski, M., Lin, Y-N., Wikman, H., Oliveira-Ferrer, L., Lange, T., Wellbrock, J., Konietzny, A., Mikhaylova, M. & Windhorst, S., 15.12.2017, In: ONCOTARGET. 8, 66, p. 110077-110091 15 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. Structural basis for subversion of host cell actin cytoskeleton during Salmonella infection

    Yuan, B., Scholz, J., Wald, J., Thuenauer, R., Hennell James, R., Ellenberg, I., Windhorst, S., Faix, J. & Marlovits, T. C., 08.12.2023, In: SCI ADV. 9, 49, p. eadj5777

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains.

    Nalaskowski, M., Windhorst, S., Stockebrand, M. C. & Mayr, G. W., 2006, In: BIOL CHEM. 387, 5, p. 583-593 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia

    Velthaus, A., Cornils, K., Hennigs, J. K., Grüb, S., Stamm, H., Wicklein, D., Bokemeyer, C., Heuser, M., Windhorst, S., Fiedler, W. & Wellbrock, J., 26.10.2019, In: CANCERS. 11, 11

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  48. The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells

    Küster, L., Paraschiakos, T., Karakurt, K. E., Schumacher, U., Diercks, B-P. & Windhorst, S., 27.02.2023, In: BIOSCIENCE REP. 43, 2, BSR20222150.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin

    Ashour, D. J., Pelka, B., Jaaks, P., Wundenberg, T., Blechner, C., Zobiak, B., Failla, A. V. & Windhorst, S., 02.2015, In: CYTOSKELETON. 72, 2, p. 93-100 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  50. The formin Drosophila homologue of Diaphanous2 (Diaph2) controls microtubule dynamics in colorectal cancer cells independent of its FH2-domain

    Grueb, S. S., Muhs, S., Popp, Y., Schmitt, S., Geyer, M., Lin, Y-N. & Windhorst, S., 29.03.2019, In: SCI REP-UK. 9, 1, p. 5352

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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