Research ExplorerScientific StaffSabine Windhorst Publications

PD.Dr. ID: 48363

Sabine Windhorst

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Publications

  1. 2005

  2. Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase.

    Mayr, G. W., Windhorst, S. & Hillemeier, K., 2005, In: J BIOL CHEM. 280, 14, p. 13229-13240 14.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. 2006

  4. Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains.

    Nalaskowski, M., Windhorst, S., Stockebrand, M. C. & Mayr, G. W., 2006, In: BIOL CHEM. 387, 5, p. 583-593 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. 2007

  6. Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase.

    Brehm, M. A., Schenk, T. M. H., Zhou, X., Fanick, W., Lin, H., Windhorst, S., Nalaskowski, M., Kobras, M., Shears, S. B. & Mayr, G. W., 2007, In: BIOCHEM J. 408, 3, p. 335-345 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis.

    Kasten-Pisula, U., Windhorst, S., Dahm-Daphi, J., Mayr, G. W. & Dikomey, E., 2007, In: RADIOTHER ONCOL. 83, 3, p. 296-303 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. 2008

  9. Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.

    Windhorst, S., Blechner, C., Lin, H., Elling, C., Nalaskowski, M., Kirchberger, T., Guse, A. H. & Mayr, G. W., 2008, In: BIOCHEM J. 414, 3, p. 407-417 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. 2010

  11. Inositol-1,4,5-trisphosphate-3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumour cells by two functional activities.

    Windhorst, S., Fliegert, R., Blechner, C., Möllmann, K., Hosseini, Z., Guenther, T., Eiben, M., Chang, L., Lin, H., Fanick, W., Schumacher, U., Brandt, B. & Mayr, G. W., 2010, In: J BIOL CHEM. 285, 8, p. 5541-5554 8.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. 2011

  13. Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.

    Windhorst, S., Kalinina, T., Schmid, K., Blechner, C., Kriebitzsch, N., Hinsch, R., Chang, L., Herich, L., Schumacher, U. & Mayr, G. W., 2011, In: INT J CANCER. 129, 6, p. 1300-1309 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.

    Nalaskowski, M., Fliegert, R., Ernst, O., Brehm, M., Fanick, W., Windhorst, S., Lin, H., Giehler, S., Hein, J., Lin, Y-N. & Mayr, G. W., 2011, In: J BIOL CHEM. 286, 6, p. 4500-4510 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. 2012

  16. Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients.

    Windhorst, S., Minge, D., Bähring, R., Hüser, S., Schob, C., Blechner, C., Lin, H., Mayr, G. W. & Kindler, S., 2012, In: CELL SIGNAL. 24, 3, p. 750-757 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. 2013

  18. Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.

    Chang, L., Schwarzenbach, H., Meyer-Staeckling, S., Brandt, B., Mayr, G. W., Weitzel, J. M. & Windhorst, S., 2013, In: MOL CANCER RES.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Malignant H1299 tumour cells preferentially internalize iron-bound inositol hexakisphosphate

    Helmis, C., Blechner, C., Lin, H., Schweizer, M., Mayr, G. W., Nielsen, P. & Windhorst, S., 01.01.2013, In: BIOSCIENCE REP. 33, 5

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation

    Windhorst, S., Lin, H., Blechner, C., Fanick, W., Brandt, L., Brehm, M. A. & Mayr, G. W., 15.02.2013, In: BIOCHEM J. 450, 1, p. 115-25 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A

    Schröder, D., Rehbach, C., Seyffarth, C., Neuenschwander, M., Kries, J. V. & Windhorst, S., 20.09.2013, In: BIOCHEM BIOPH RES CO. 439, 2, p. 228-34 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma

    Ewald, F., Grabinski, N., Grottke, A., Windhorst, S., Nörz, D., Carstensen, L., Staufer, K., Hofmann, B. T., Diehl, F., David, K., Schumacher, U., Nashan, B. & Jücker, M., 01.11.2013, In: INT J CANCER. 133, 9, p. 2065-76 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. 2014

  24. Expression, Purification and preliminary X-Ray diffraction of a pathogenic bacterial protease from Stenotrophomonas maltophilia

    Negm, A., Windhorst, S., Betzel, C., Akrem, A. & Weber, W., 2014, In: World J Pharm Pharm Sci. 3, 10, p. 13-23

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5

    Riley, A. M., Windhorst, S., Lin, H. & Potter, B. V. L., 03.01.2014, In: CHEMBIOCHEM. 15, 1, p. 57-67 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. Expression of DIAPH1 is up-regulated in colorectal cancer and its down-regulation strongly reduces the metastatic capacity of colon carcinoma cells

    Lin, Y-N., Izbicki, J. R., König, A., Habermann, J. K., Blechner, C., Lange, T., Schumacher, U. & Windhorst, S., 01.04.2014, In: INT J CANCER. 134, 7, p. 1571-82 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. 2015

  28. The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin

    Ashour, D. J., Pelka, B., Jaaks, P., Wundenberg, T., Blechner, C., Zobiak, B., Failla, A. V. & Windhorst, S., 02.2015, In: CYTOSKELETON. 72, 2, p. 93-100 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. Ex vivo aorta patch model for analysis of cellular adhesion

    Lin, Y-N., Thata, R. N., Failla, A. V., Geissen, M., Daum, G. & Windhorst, S., 06.2015, In: TISSUE CELL. 47, 3, p. 266-272 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells

    Schröder, D., Tödter, K., Gonzalez, B., Franco-Echevarría, E., Rohaly, G., Blechner, C., Lin, H., Mayr, G. W. & Windhorst, S., 15.07.2015, In: BIOCHEM PHARMACOL. 96, 2, p. 143-50 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion

    Lin, Y-N., Bhuwania, R., Gromova, K., Failla, A. V., Lange, T., Riecken, K., Linder, S., Kneussel, M., Izbicki, J. R. & Windhorst, S., 30.07.2015, In: ONCOTARGET. 6, 21, p. 18577-89 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. 2016

  33. Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity

    Chen, L., DeWispelaere, A., Dastvan, F., Osborne, W. R. A., Blechner, C., Windhorst, S. & Daum, G., 2016, In: PLOS ONE. 11, 5, p. e0155726

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines

    Köster, J-D., Leggewie, B., Blechner, C., Brandt, N., Fester, L., Rune, G., Schweizer, M., Kindler, S. & Windhorst, S., 01.2016, In: CELL SIGNAL. 28, 1, p. 83-90 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. Control of aromatase in hippocampal neurons

    Fester, L., Brandt, N., Windhorst, S., Pröls, F., Bläute, C. & Rune, G. M., 01.06.2016, In: J STEROID BIOCHEM. 160, p. 9-14

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  36. Diaphanous-related formin 1 as a target for tumor therapy

    Lin, Y-N. & Windhorst, S., 15.10.2016, In: BIOCHEM SOC T. 44, 5, p. 1289-1293 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. 2017

  38. Tight Junction Proteins Claudin-1 and Occludin Are Important for Cutaneous Wound Healing

    Volksdorf, T., Heilmann, J., Eming, S. A., Schawjinski, K., Zorn-Kruppa, M., Ueck, C., Vidal-Y-Sy, S., Windhorst, S., Jücker, M., Moll, I. & Brandner, J. M., 06.2017, In: AM J PATHOL. 187, 6, p. 1301-1312

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  39. Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types

    Windhorst, S., Song, K. & Gazdar, A. F., 01.08.2017, In: BIOCHEM PHARMACOL. 137, p. 1-9 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  40. Microtubules Modulate F-actin Dynamics during Neuronal Polarization

    Zhao, B., Meka, P., Scharrenberg, R., König, T., Schwanke, B., Kobler, O., Windhorst, S., Kreutz, M. R., Mikhaylova, M. & Calderon de Anda, F., 29.08.2017, In: SCI REP-UK. 7, 1, p. 9583

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  41. Strong fascin expression promotes metastasis independent of its F-actin bundling activity

    Heinz, L. S., Muhs, S., Schiewek, J., Grüb, S., Nalaskowski, M., Lin, Y-N., Wikman, H., Oliveira-Ferrer, L., Lange, T., Wellbrock, J., Konietzny, A., Mikhaylova, M. & Windhorst, S., 15.12.2017, In: ONCOTARGET. 8, 66, p. 110077-110091 15 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. 2018

  43. Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells

    Bäder, S., Glaubke, E., Grüb, S., Muhs, S., Wellbrock, J., Nalaskowski, M., Lange, T. & Windhorst, S., 26.06.2018, In: BIOCHEM J. 475, 12, p. 2057-2071 15 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. Differential Proteome Analysis of Human Neuroblastoma Xenograft Primary Tumors and Matched Spontaneous Distant Metastases

    Hänel, L., Gosau, T., Maar, H., Valentiner, U., Schumacher, U., Riecken, K., Windhorst, S., Hansen, N-O., Heikaus, L., Wurlitzer, M., Nolte, I., Schlüter, H. & Lange, T., 09.2018, In: SCI REP-UK. 8, 1, p. 13986

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. Clinical relevance of cytoskeleton associated proteins for ovarian cancer

    Schiewek, J., Schumacher, U., Lange, T., Joosse, S. A., Wikman, H., Pantel, K., Mikhaylova, M., Kneussel, M., Linder, S., Schmalfeldt, B., Oliveira-Ferrer, L. & Windhorst, S., 11.2018, In: J CANCER RES CLIN. 144, 11, p. 2195-2205 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. 2019

  47. Inositol hexakisphosphate increases the size of platelet aggregates

    Brehm, M. A., Klemm, U., Rehbach, C., Erdmann, N., Kolšek, K., Lin, H., Aponte-Santamaría, C., Gräter, F., Rauch, B. H., Riley, A. M., Mayr, G. W., Potter, B. V. L. & Windhorst, S., 03.2019, In: BIOCHEM PHARMACOL. 161, p. 14-25 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  48. The formin Drosophila homologue of Diaphanous2 (Diaph2) controls microtubule dynamics in colorectal cancer cells independent of its FH2-domain

    Grueb, S. S., Muhs, S., Popp, Y., Schmitt, S., Geyer, M., Lin, Y-N. & Windhorst, S., 29.03.2019, In: SCI REP-UK. 9, 1, p. 5352

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. New options of cancer treatment employing InsP6

    Brehm, M. A. & Windhorst, S., 05.2019, In: BIOCHEM PHARMACOL. 163, p. 206-214 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  50. The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia

    Velthaus, A., Cornils, K., Hennigs, J. K., Grüb, S., Stamm, H., Wicklein, D., Bokemeyer, C., Heuser, M., Windhorst, S., Fiedler, W. & Wellbrock, J., 26.10.2019, In: CANCERS. 11, 11

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  51. Radial somatic F-actin organization affects growth cone dynamics during early neuronal development

    Meka, D. P., Scharrenberg, R., Zhao, B., Kobler, O., König, T., Schaefer, I., Schwanke, B., Klykov, S., Richter, M., Eggert, D., Windhorst, S., Dotti, C. G., Kreutz, M. R., Mikhaylova, M. & Calderon de Anda, F., 05.12.2019, In: EMBO REP. 20, 12, p. e47743

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  52. 2020

  53. Mice lacking plastin-3 display a specific defect of cortical bone acquisition

    Yorgan, T., Sari, H., Rolvien, T., Windhorst, S., Failla, A. V., Kornak, U., Oheim, R., Amling, M. & Schinke, T., 01.2020, In: BONE. 130, p. 115062

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  54. Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice

    Labitzky, V., Baranowsky, A., Maar, H., Hanika, S., Starzonek, S., Ahlers, A-K., Stübke, K., Koziolek, E. J., Heine, M., Schäfer, P., Windhorst, S., Jücker, M., Riecken, K., Amling, M., Schinke, T., Schumacher, U., Valentiner, U. & Lange, T., 07.02.2020, In: CANCERS. 12, 2

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  55. Conserved Tao Kinase Activity Regulates Dendritic Arborization, Cytoskeletal Dynamics, and Sensory Function in Drosophila

    Hu, C., Kanellopoulos, A. K., Richter, M., Petersen, M., Konietzny, A., Tenedini, F. M., Hoyer, N., Cheng, L., Poon, C. L. C., Harvey, K. F., Windhorst, S., Parrish, J. Z., Mikhaylova, M., Bagni, C., Calderon de Anda, F. & Soba, P., 26.02.2020, In: J NEUROSCI. 40, 9, p. 1819-1833 15 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  56. Characterization of the substrate specificity of the inositol 5-phosphatase SHIP1

    Nelson, N., Wundenberg, T., Lin, H., Rehbach, C., Horn, S., Windhorst, S. & Jücker, M., 02.04.2020, In: BIOCHEM BIOPH RES CO. 524, 2, p. 366-370 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  57. Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice

    Blechner, C., Becker, L., Fuchs, H., Rathkolb, B., Prehn, C., Adler, T., Calzada-Wack, J., Garrett, L., Gailus-Durner, V., Morellini, F., Conrad, S., Hölter, S. M., Wolf, E., Klopstock, T., Adamski, J., Busch, D., de Angelis, M. H., Schmeisser, M. J. & Windhorst, S., 14.09.2020, In: NEUROSCI LETT. 735, p. 135206

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  58. Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells is associated with brain metastasis and alters exosome biogenesis

    Arnold, J., Schattschneider, J., Blechner, C., Krisp, C., Schlüter, H., Schweizer, M., Nalaskowski, M., Oliveira-Ferrer, L. & Windhorst, S., 30.09.2020, In: J EXP CLIN CANC RES. 39, 1, p. 205

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  59. 2021

  60. DIAPH1 regulates chromosomal instability of cancer cells by controlling microtubule dynamics

    Miao, S., Schäfer, P., Nojszewski, J., Meyer, F. & Windhorst, S., 04.2021, In: EUR J CELL BIOL. 100, 3, 151156.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  61. 2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: identification of a new and potent inhibitor

    Löhndorf, A., Hosang, L., Dohle, W., Odoardi, F., Waschkowski, S-A., Rosche, A., Bauche, A., Winzer, R., Tolosa, E., Windhorst, S., Marry, S., Flügel, A., Potter, B. V. L., Diercks, B-P. & Guse, A. H., 05.2021, In: BBA-MOL CELL RES. 1868, 6, p. 118988

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  62. Mechanism of BIP-4 mediated inhibition of InsP3Kinase-A

    Paraschiakos, T., Flat, W., Chen, Y., Kirchmair, J. & Windhorst, S., 30.07.2021, In: BIOSCIENCE REP. 41, 7, BSR20211259.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  63. Oncogenic activity and cellular functionality of melanoma associated antigen A3

    Schäfer, P., Paraschiakos, T. & Windhorst, S., 10.2021, In: BIOCHEM PHARMACOL. 192, 114700.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  64. Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density

    Middelkamp, M., Ruck, L., Krisp, C., Sumisławski, P., Mohammadi, B., Dottermusch, M., Meister, V., Küster, L., Schlüter, H., Windhorst, S. & Neumann, J. E., 20.11.2021, In: ACTA NEUROPATHOL COM. 9, 1, p. 185

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  65. 2022

  66. DIAPH1 facilitates paclitaxel-mediated cytotoxicity of ovarian cancer cells

    Flat, W., Borowski, S., Paraschiakos, T., Blechner, C. & Windhorst, S., 03.2022, In: BIOCHEM PHARMACOL. 197, 114898.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  67. Key Role of Hyaluronan Metabolism for the Development of Brain Metastases in Triple-Negative Breast Cancer

    Hamester, F., Stürken, C., Legler, K., Eylmann, K., Möller, K., Roßberg, M., Gorzelanny, C., Bauer, A. T., Windhorst, S., Schmalfeldt, B., Laakmann, E., Müller, V., Witzel, I. & Oliveira-Ferrer, L., 18.10.2022, In: CELLS-BASEL. 11, 20, 3275.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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