Prof.Dr.rer.nat ID: 73722
Thorsten Schinke
Publications
- 2020
Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency
Oheim, R., Zimmerman, K., Maulding, N. D., Stürznickel, J., von Kroge, S., Kavanagh, D., Stabach, P. R., Kornak, U., Tommasini, S. M., Horowitz, M. C., Amling, M., Thompson, D., Schinke, T., Busse, B., Carpenter, T. O. & Braddock, D. T., 03.2020, In: J BONE MINER RES. 35, 3, p. 528-539 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Skeletal deterioration in COL2A1-related spondyloepiphyseal dysplasia occurs prior to osteoarthritis
Rolvien, T., Yorgan, T. A., Kornak, U., Hermans-Borgmeyer, I., Mundlos, S., Schmidt, T., Niemeier, A., Schinke, T., Amling, M. & Oheim, R., 03.2020, In: OSTEOARTHR CARTILAGE. 28, 3, p. 334-343 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice
Labitzky, V., Baranowsky, A., Maar, H., Hanika, S., Starzonek, S., Ahlers, A-K., Stübke, K., Koziolek, E. J., Heine, M., Schäfer, P., Windhorst, S., Jücker, M., Riecken, K., Amling, M., Schinke, T., Schumacher, U., Valentiner, U. & Lange, T., 07.02.2020, In: CANCERS. 12, 2Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A System to Determine Risk of Osteoporosis in Patients With Autoimmune Hepatitis
Schmidt, T., Schmidt, C., Strahl, A., Mussawy, H., Rolvien, T., Jandl, N. M., Casar, C., Oheim, R., Schinke, T., Lohse, A. W., Amling, M., Schramm, C. & Barvencik, F., 01.2020, In: CLIN GASTROENTEROL H. 18, 1, p. 226-233.e3Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mice lacking plastin-3 display a specific defect of cortical bone acquisition
Yorgan, T., Sari, H., Rolvien, T., Windhorst, S., Failla, A. V., Kornak, U., Oheim, R., Amling, M. & Schinke, T., 01.2020, In: BONE. 130, p. 115062Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Development of Enthesopathies and Joint Structural Damage in a Murine Model of X-Linked Hypophosphatemia
Faraji-Bellée, C-A., Cauliez, A., Salmon, B., Fogel, O., Zhukouskaya, V., Benoit, A., Schinke, T., Roux, C., Linglart, A., Miceli-Richard, C., Chaussain, C., Briot, K. & Bardet, C., 2020, In: FRONT CELL DEV BIOL. 8, p. 854Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2019
Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling
Yorgan, T., Peters, S., Amling, M. & Schinke, T., 10.2019, In: BONE. 127, p. 155-163 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Secreted factors from synovial fibroblasts immediately regulate gene expression in articular chondrocytes
Bonitz, M., Schaffer, C., Amling, M., Poertner, R., Schinke, T. & Jeschke, A., 25.05.2019, In: GENE. 698, p. 1-8 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Th17 cell frequency is associated with low bone mass in primary sclerosing cholangitis
Schmidt, T., Schwinge, D., Rolvien, T., Jeschke, A., Schmidt, C., Neven, M., Butscheidt, S., Kriz, M., Kunzmann, L., Mussawy, H., Hubert, J., Hawellek, T., Rüther, W., Oheim, R., Barvencik, F., Lohse, A. W., Schramm, C., Schinke, T. & Amling, M., 05.2019, In: J HEPATOL. 70, 5, p. 941-953 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A novel FAM20C mutation causing hypophosphatemic osteomalacia with osteosclerosis (mild Raine syndrome) in an elderly man with spontaneous osteonecrosis of the knee
Rolvien, T., Kornak, U., Schinke, T., Amling, M. & Oheim, R., 03.2019, In: OSTEOPOROSIS INT. 30, 3, p. 685-689 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Chemokines in Physiological and Pathological Bone Remodeling
Brylka, L. J. & Schinke, T., 2019, In: FRONT IMMUNOL. 10, p. 2182Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase
Heckt, T., Brylka, L. J., Neven, M., Amling, M. & Schinke, T., 2019, In: PLOS ONE. 14, 7, p. e0219734Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Impaired mineral quality in dentin in X-linked hypophosphatemia
Coyac, B. R., Falgayrac, G., Penel, G., Schmitt, A., Schinke, T., Linglart, A., McKee, M. D., Chaussain, C. & Bardet, C., 12.2018, In: CONNECT TISSUE RES. 59, Supp.1, p. 91-96 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover
Pohl, S., Angermann, A., Jeschke, A., Hendrickx, G., Yorgan, T. A., Makrypidi-Fraune, G., Steigert, A., Kuehn, S. C., Rolvien, T., Schweizer, M., Koehne, T., Neven, M., Winter, O., Velho, R. V., Albers, J., Streichert, T., Pestka, J. M., Baldauf, C., Breyer, S., Stuecker, R., Muschol, N., Cox, T. M., Saftig, P., Paganini, C., Rossi, A., Amling, M., Braulke, T. & Schinke, T., 12.2018, In: J BONE MINER RES. 33, 12, p. 2186-2201 16 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand
Luther, J., Yorgan, T. A., Rolvien, T., Ulsamer, L., Koehne, T., Liao, N., Keller, D., Vollersen, N., Teufel, S., Neven, M., Peters, S., Schweizer, M., Trumpp, A., Rosigkeit, S., Bockamp, E., Mundlos, S., Kornak, U., Oheim, R., Amling, M., Schinke, T. & David, J-P., 07.11.2018, In: SCI TRANSL MED. 10, 466, p. eaau7137Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Comparison of Bone Microarchitecture Between Adult Osteogenesis Imperfecta and Early-Onset Osteoporosis
Rolvien, T., Stürznickel, J., Schmidt, F. N., Butscheidt, S., Schmidt, T., Busse, B., Mundlos, S., Schinke, T., Kornak, U., Amling, M. & Oheim, R., 11.2018, In: CALCIFIED TISSUE INT. 103, 5, p. 512-521 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lysosomal Proteome and Secretome Analysis Identifies Missorted Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse Cells
Di Lorenzo, G., Velho, R. V., Winter, D., Thelen, M., Ahmadi, S., Schweizer, M., De Pace, R., Cornils, K., Yorgan, T. A., Grüb, S., Hermans-Borgmeyer, I., Schinke, T., Müller-Loennies, S., Braulke, T. & Pohl, S., 08.2018, In: MOL CELL PROTEOMICS. 17, 8, p. 1612-1626 15 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mutational analysis uncovers monogenic bone disorders in women with pregnancy-associated osteoporosis: three novel mutations in LRP5, COL1A1, and COL1A2
Butscheidt, S., Delsmann, A., Rolvien, T., Barvencik, F., Al-Bughaili, M., Mundlos, S., Schinke, T., Amling, M., Kornak, U. & Oheim, R., 07.2018, In: OSTEOPOROSIS INT. 29, 7, p. 1643-1651 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Disease duration and stage influence bone microstructure in patients with primary biliary cholangitis
Schmidt, T., Schmidt, C., Schmidt, F. N., Butscheidt, S., Mussawy, H., Hubert, J., Hawellek, T., Oehler, N., Barvencik, F., Lohse, A. W., Schinke, T., Schramm, C., Amling, M. & Rolvien, T., 06.2018, In: J BONE MINER RES. 33, 6, p. 1011-1019 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Gegenseitige Beeinflussung von Immunsystem und Knochen
Kamradt, T., Amling, M., Dankbar, B., Dudeck, A., Gunzer, M., Ignatius, A., Krönke, G., Kubatzky, K., Pap, T., Prinz, I., Schett, G., Schinke, T., Tuckermann, J. & Waisman, A., 05.2018, In: Z RHEUMATOL. 77, Suppl 1, p. 8-11 4 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis
Hendrickx, G., Borra, V. M., Steenackers, E., Yorgan, T. A., Hermans, C., Boudin, E., Waterval, J. J., Jansen, I. D. C., Aydemir, T. B., Kamerling, N., Behets, G. J., Plumeyer, C., D'Haese, P. C., Busse, B., Everts, V., Lammens, M., Mortier, G., Cousins, R. J., Schinke, T., Stokroos, R. J., Manni, J. J. & Van Hul, W., 04.2018, In: PLOS GENET. 14, 4, p. e1007321Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Differences in maxillomandibular morphology among patients with mucopolysaccharidoses I, II, III, IV and VI: a retrospective MRI study
Koehne, T., Köhn, A., Friedrich, R. E., Kordes, U., Schinke, T., Muschol, N. & Kahl-Nieke, B., 04.2018, In: CLIN ORAL INVEST. 22, 3, p. 1541-1549 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica
Chan, W. L., Steiner, M., Witkos, T., Egerer, J., Busse, B., Mizumoto, S., Pestka, J. M., Zhang, H., Hausser, I., Khayal, L. A., Ott, C-E., Kolanczyk, M., Willie, B., Schinke, T., Paganini, C., Rossi, A., Sugahara, K., Amling, M., Knaus, P., Chan, D., Lowe, M., Mundlos, S. & Kornak, U., 21.03.2018, In: PLOS GENET. 14, 3, p. e1007242Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The high bone mass phenotype of Lrp5-mutant mice is not affected by megakaryocyte depletion
Yorgan, T., David, J-P., Amling, M. & Schinke, T., 04.03.2018, In: BIOCHEM BIOPH RES CO. 497, 2, p. 659-666 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A novel COL1A2 C-propeptide cleavage site mutation causing high bone mass osteogenesis imperfecta with a regional distribution pattern
Rolvien, T., Kornak, U., Stürznickel, J., Schinke, T., Amling, M., Mundlos, S. & Oheim, R., 01.2018, In: OSTEOPOROSIS INT. 29, 1, p. 243-246 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Clinical Significance of DXA and HR-pQCT in Autosomal Dominant Osteopetrosis (ADO II)
Butscheidt, S., Rolvien, T., Kornak, U., Schmidt, F. N., Schinke, T., Amling, M. & Oheim, R., 01.2018, In: CALCIFIED TISSUE INT. 102, 1, p. 41-52 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High bone turnover in mice carrying a pathogenic Notch2-mutation causing Hajdu-Cheney syndrome
Vollersen, N., Hermans-Borgmeyer, I., Cornils, K., Fehse, B., Rolvien, T., Triviai, I., Jeschke, A., Oheim, R., Amling, M., Schinke, T. & Yorgan, T. A., 01.2018, In: J BONE MINER RES. 33, 1, p. 70-83 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation
Geissler, S., Textor, M., Stumpp, S., Seitz, S., Lekaj, A., Brunk, S., Klaassen, S., Schinke, T., Klein, C., Mundlos, S., Kornak, U. & Kühnisch, J., 2018, In: PLOS ONE. 13, 6, p. e0198510Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling
Bartelt, A., Behler-Janbeck, F., Beil, F. T., Koehne, T., Müller, B., Schmidt, T., Heine, M., Ochs, L., Yilmaz, T., Dietrich, M., Tuckermann, J. P., Amling, M., Herz, J., Schinke, T., Heeren, J. & Niemeier, A., 2018, In: BONE RES. 6, p. 4Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2017
Mast Cells Are Critical Regulators of Bone Fracture-Induced Inflammation and Osteoclast Formation and Activity
Kroner, J., Kovtun, A., Kemmler, J., Messmann, J. J., Strauss, G., Seitz, S., Schinke, T., Amling, M., Kotrba, J., Froebel, J., Dudeck, J., Dudeck, A. & Ignatius, A., 12.2017, In: J BONE MINER RES. 32, 12, p. 2431-2444Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Post-weaning epiphysiolysis causes distal femur dysplasia and foreshortened hindlimbs in fetuin-A-deficient mice
Brylka, L. J., Köppert, S., Babler, A., Kratz, B., Denecke, B., Yorgan, T. A., Etich, J., Costa, I. G., Brachvogel, B., Boor, P., Schinke, T. & Jahnen-Dechent, W., 31.10.2017, In: PLOS ONE. 12, 10, p. e0187030Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Severe bone loss and multiple fractures in SCN8A-related epileptic encephalopathy
Rolvien, T., Butscheidt, S., Jeschke, A., Neu, A., Denecke, J., Kubisch, C., Meisler, M. H., Püschel, K., Barvencik, F., Yorgan, T., Oheim, R., Schinke, T. & Amling, M., 10.2017, In: BONE. 103, p. 136-143Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Tissue-specific mineralization defects in the periodontium of the Hyp mouse model of X-linked hypophosphatemia
Coyac, B. R., Falgayrac, G., Baroukh, B., Slimani, L., Sadoine, J., Penel, G., Biosse-Duplan, M., Schinke, T., Linglart, A., McKee, M. D., Chaussain, C. & Bardet, C., 10.2017, In: BONE. 103, p. 334-346 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone
Rolvien, T., Krause, M., Jeschke, A., Yorgan, T., Püschel, K., Schinke, T., Busse, B., Demay, M. B. & Amling, M., 10.2017, In: BONE. 103, p. 78-87 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice
Fischer, V., Haffner-Luntzer, M., Prystaz, K., Scheidt, A. V., Busse, B., Schinke, T., Amling, M. & Ignatius, A., 03.08.2017, In: SCI REP-UK. 7, 1, p. Art. 7223Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta
Gioia, R., Tonelli, F., Ceppi, I., Biggiogera, M., Leikin, S., Fisher, S., Tenedini, E., Yorgan, T. A., Schinke, T., Tian, K., Schwartz, J-M., Forte, F., Wagener, R., Villani, S., Rossi, A. & Forlino, A., 01.08.2017, In: HUM MOL GENET. 26, 15, p. 2897-2911 15 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Lrp4R1170Q Homozygous Knock-In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans
Boudin, E., Yorgan, T., Fijalkowski, I., Sonntag, S., Steenackers, E., Hendrickx, G., Peeters, S., De Maré, A., Vervaet, B., Verhulst, A., Mortier, G., D'Haese, P., Schinke, T. & Van Hul, W., 08.2017, In: J BONE MINER RES. 32, 8, p. 1739-1749 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing
Bergdolt, S., Kovtun, A., Hägele, Y., Liedert, A., Schinke, T., Amling, M., Huber-Lang, M. & Ignatius, A., 14.06.2017, In: PLOS ONE. 12, 6, p. e0179512Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A Novel ANO5 Mutation Causing Gnathodiaphyseal Dysplasia With High Bone Turnover Osteosclerosis
Rolvien, T., Koehne, T., Kornak, U., Lehmann, W., Amling, M., Schinke, T. & Oheim, R., 02.2017, In: J BONE MINER RES. 32, 2, p. 277-284Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Differential effects of Calca-derived peptides in male mice with diet-induced obesity
Bartelt, A., Jeschke, A., Müller, B., Gaziano, I., Morales, M., Yorgan, T., Heckt, T., Heine, M., Gagel, R. F., Emeson, R. B., Amling, M., Niemeier, A., Heeren, J., Schinke, T. & Keller, J., 2017, In: PLOS ONE. 12, 6, p. e0180547Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Significance of DXA and HR-pQCT for the Diagnosis of Osteopetrosis (ADO II)-Establishment of a Diagnostic Threshold.
Butscheidt, S., Rolvien, T., Kornak, U., Schmidt, F. N., Schinke, T., Amling, M. & Oheim, R., 2017, In: J BONE MINER RES. 32, p. S167-S167Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review
- 2016
Letter to the Editor, concerning: "FGF23-regulated production of fetuin-A (AHSG) in osteocytes"
Jahnen-Dechent, W., Brylka, L., Schinke, T. & McKee, M. D., 12.2016, In: BONE. 93, p. 223-224 2 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Hypochlorhydria-induced calcium malabsorption does not affect fracture healing but increases post-traumatic bone loss in the intact skeleton
Haffner-Luntzer, M., Heilmann, A., Heidler, V., Liedert, A., Schinke, T., Amling, M., Yorgan, T. A., Vom Scheidt, A. & Ignatius, A., 11.2016, In: J ORTHOP RES. 34, 11, p. 1914-1921 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Parathyroid hormone induces expression and proteolytic processing of Rankl in primary murine osteoblasts
Heckt, T., Keller, J., Peters, S., Streichert, T., Chalaris, A., Rose-John, S., Mell, B., Joe, B., Amling, M. & Schinke, T., 11.2016, In: BONE. 92, p. 85-93 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mannose 6-phosphate-dependent targeting of lysosomal enzymes is required for normal craniofacial and dental development
Koehne, T., Markmann, S., Schweizer, M., Muschol, N., Friedrich, R. E., Hagel, C., Glatzel, M., Kahl-Nieke, B., Amling, M., Schinke, T. & Braulke, T., 09.2016, In: BBA-MOL BASIS DIS. 1862, 9, p. 1570–1580Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Antagonizing midkine accelerates fracture healing in mice by enhanced bone formation in the fracture callus
Haffner-Luntzer, M., Heilmann, A., Rapp, A. E., Roessler, R., Schinke, T., Amling, M., Ignatius, A. & Liedert, A., 07.2016, In: BRIT J PHARMACOL. 173, 14, p. 2237-49 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Osteoblast-specific Notch2 inactivation causes increased trabecular bone mass at specific sites of the appendicular skeleton
Yorgan, T., Vollersen, N., Riedel, C., Jeschke, A., Peters, S., Busse, B., Amling, M. & Schinke, T., 06.2016, In: BONE. 87, p. 136-46 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts
Uluçkan, Ö., Jimenez, M., Karbach, S., Jeschke, A., Graña, O., Keller, J., Busse, B., Croxford, A. L., Finzel, S., Koenders, M., van den Berg, W., Schinke, T., Amling, M., Waisman, A., Schett, G. & Wagner, E. F., 16.03.2016, In: SCI TRANSL MED. 8, 330, p. 330ra37Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Immediate effects of retinoic acid on gene expression in primary murine osteoblasts
Yorgan, T. A., Heckt, T., Rendenbach, C., Helmis, C., Seitz, S., Streichert, T., Amling, M. & Schinke, T., 01.03.2016, In: J BONE MINER METAB. 34, 2, p. 161-70Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Rsk2, the kinase in Coffin-Lowry syndrome controls cementum formation
Koehne, T., Jeschke, A., Petermann, F., Seitz, S., Neven, M., Peters, S., Luther, J., Schweizer, M., Schinke, T., Kahl-Nieke, B., Amling, M. & David, J-P., 29.02.2016, In: J DENT RES. 95, 7, p. 752-760Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review