Dr. ID: 33519
Kerstin Borgmann
Publications
- 2024
USP7 Deregulation Impairs S Phase Specific DNA Repair after Irradiation in Breast Cancer Cells
Vogt, M., Classen, S., Krause, A. K., Peter, N. J., Petersen, C., Rothkamm, K., Borgmann, K. & Meyer, F., 29.03.2024, In: BIOMEDICINES. 12, 4, 762.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Successful implementation of online educational lectures of the German Society for Radiation Oncology (DEGRO)
Büttner, M., Melton, P., Fietkau, R., Petersen, C., Krause, M., Borgmann, K., Wolf, U., Niyazi, M., Christiansen, H., Höller, U., Schmitt, D., Käsmann, L., Linde, P., Fleischmann, D. F., Ziegler, S., Bresch, A. & Mäurer, M., 02.2024, In: STRAHLENTHER ONKOL. 200, 2, p. 151-158 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2023
Crosstalk between immune checkpoint and DNA damage response inhibitors for radiosensitization of tumors
Classen, S., Petersen, C. & Borgmann, K., 12.2023, In: STRAHLENTHER ONKOL. 199, 12, p. 1152-1163 12 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Das BRCA-like-Mammakarzinom profitiert von Cisplatin plus Veliparib; Ergebnisse der S1416-Phase-II-Studie
Hintelmann, K. & Borgmann, K., 12.2023, In: STRAHLENTHER ONKOL. 199, 12, p. 1258-1261 4 p.Research output: SCORING: Contribution to journal › Editorial › Research
DNA as the main target in radiotherapy-a historical overview from first isolation to anti-tumour immune response
Frey, B., Borgmann, K., Jost, T., Greve, B., Oertel, M., Micke, O. & Eckert, F., 12.2023, In: STRAHLENTHER ONKOL. 199, 12, p. 1080-1090 11 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis
Kempska, J., Oliveira-Ferrer, L., Grottke, A., Qi, M., Alawi, M., Meyer, F., Borgmann, K., Hamester, F., Eylmann, K., Rossberg, M., Smit, D. J., Jücker, M., Laakmann, E., Witzel, I., Schmalfeldt, B., Müller, V. & Legler, K., 06.07.2023, In: FRONT ONCOL. 13, p. 1129682 1129682.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The prognostic impact of B7-H3 and B7-H4 in head and neck squamous cell carcinoma
Borgmann, M., Oetting, A., Meyer, F., Möckelmann, N., Droste, C., von Bargen, C. M., Möller-Koop, C., Witt, M., Borgmann, K., Rothkamm, K., Betz, C., Münscher, A., Clauditz, T. S. & Rieckmann, T., 07.2023, In: J CANCER RES CLIN. 149, 7, p. 3383-3393 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Radiotherapeutic Strategies to Overcome Resistance of Breast Cancer Brain Metastases by Considering Immunogenic Aspects of Cancer Stem Cells
Hintelmann, K., Petersen, C. & Borgmann, K., 01.2023, In: CANCERS. 15, 1, 211.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells
Gehre, S., Meyer, F., Sengedorj, A., Grottker, F., Reichardt, C. M., Alomo, J., Borgmann, K., Frey, B., Fietkau, R., Rückert, M. & Gaipl, U. S., 2023, In: FRONT ONCOL. 13, p. 981239Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2022
Partial Reduction in BRCA1 Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance
Classen, S., Rahlf, E., Jungwirth, J., Albers, N., Hebestreit, L. P., Zielinski, A., Poole, L., Groth, M., Koch, P., Liehr, T., Kankel, S., Cordes, N., Petersen, C., Rothkamm, K., Pospiech, H. & Borgmann, K., 01.11.2022, In: INT J MOL SCI. 23, 21, 13363.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Efficient DNA repair mitigates replication stress resulting in less immunogenic cytosolic DNA in radioresistant breast cancer stem cells
Meyer, F., Engel, A. M., Krause, A. K., Wagner, T., Poole, L., Dubrovska, A., Peitzsch, C., Rothkamm, K., Petersen, C. & Borgmann, K., 22.02.2022, In: FRONT IMMUNOL. 13, p. 765284 765284.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2021
Beyond the Double-Strand Breaks: The Role of DNA Repair Proteins in Cancer Stem-Cell Regulation
Nathansen, J., Meyer, F., Müller, L., Schmitz, M., Borgmann, K. & Dubrovska, A., 26.09.2021, In: CANCERS. 13, 19, 4818.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Molecular Mechanisms Associated with Brain Metastases in HER2-Positive and Triple Negative Breast Cancers
Bryan, S., Witzel, I., Borgmann, K. & Oliveira-Ferrer, L., 17.08.2021, In: CANCERS. 13, 16, 4137.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L
Nathansen, J., Lukiyanchuk, V., Hein, L., Stolte, M-I., Borgmann, K., Löck, S., Kurth, I., Baumann, M., Krause, M., Linge, A. & Dubrovska, A., 06.2021, In: ONCOGENE. 40, 24, p. 4214-4228 15 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Late Sequelae of Radiotherapy: The Effect of Technical and Conceptual Innovations in Radiation Oncology
Hoeller, U., Borgmann, K., Oertel, M., Haverkamp, U., Budach, V. & Eich, H. T., 26.03.2021, In: DTSCH ARZTEBL INT. 118, 12, p. 205-211 7 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
DNA Damage Response during Replication Correlates with CIN70 Score and Determines Survival in HNSCC Patients
Bold, I. T., Specht, A-K., Droste, C. F., Zielinski, A., Meyer, F., Clauditz, T. S., Münscher, A., Werner, S., Rothkamm, K., Petersen, C. & Borgmann, K., 10.03.2021, In: CANCERS. 13, 6Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Targeting the DNA replication stress phenotype of KRAS mutant cancer cells
Al Zubaidi, T., Gehrisch, O. H. F., Genois, M-M., Liu, Q., Lu, S., Kung, J., Xie, Y., Schuemann, J., Lu, H-M., Hata, A. N., Zou, L., Borgmann, K. & Willers, H., 11.02.2021, In: SCI REP-UK. 11, 1, 3656.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2020
The POLD1R689W variant increases the sensitivity of colorectal cancer cells to ATR and CHK1 inhibitors
Job, A., Tatura, M., Schäfer, C., Lutz, V., Schneider, H., Lankat-Buttgereit, B., Zielinski, A., Borgmann, K., Bauer, C., Gress, T. M., Buchholz, M. & Gallmeier, E., 03.11.2020, In: SCI REP-UK. 10, 1, p. 18924Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner
Rieckhoff, J., Meyer, F., Classen, S., Zielinski, A., Riepen, B., Wikman, H., Petersen, C., Rothkamm, K., Borgmann, K. & Parplys, A. C., 29.09.2020, In: CANCERS. 12, 10Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity
Koch, C., Kuske, A., Joosse, S. A., Yigit, G., Sflomos, G., Thaler, S., Smit, D. J., Werner, S., Borgmann, K., Gärtner, S., Mossahebi Mohammadi, P., Battista, L., Cayrefourcq, L., Altmüller, J., Salinas-Riester, G., Raithatha, K., Zibat, A., Goy, Y., Ott, L., Bartkowiak, K., Tan, T. Z., Zhou, Q., Speicher, M. R., Müller, V., Gorges, T. M., Jücker, M., Thiery, J-P., Brisken, C., Riethdorf, S., Alix-Panabières, C. & Pantel, K., 07.09.2020, In: EMBO MOL MED. 12, 9, e11908.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Intermediate Filament Synemin Regulates Non-Homologous End Joining in an ATM-Dependent Manner
Deville, S. S., Vehlow, A., Förster, S., Dickreuter, E., Borgmann, K. & Cordes, N., 28.06.2020, In: CANCERS. 12, 7Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer
Meyer, F., Becker, S., Classen, S., Parplys, A. C., Mansour, W. Y., Riepen, B., Timm, S., Ruebe, C., Jasin, M., Wikman, H., Petersen, C., Rothkamm, K. & Borgmann, K., 17.01.2020, In: CELLS-BASEL. 9, 1Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2019
BRCA1 mislocalization leads to aberrant DNA damage response in heterozygous ABRAXAS1 mutation carrier cells
Bose, M., Sachsenweger, J., Laurila, N., Parplys, A. C., Willmann, J., Jungwirth, J., Groth, M., Rapakko, K., Nieminen, P., Friedl, T. W. P., Heiserich, L., Meyer, F., Tuppurainen, H., Peltoketo, H., Nevanlinna, H., Pylkäs, K., Borgmann, K., Wiesmüller, L., Winqvist, R. & Pospiech, H., 15.12.2019, In: HUM MOL GENET. 28, 24, p. 4148-4160 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Clonality of circulating tumor cells in breast cancer brain metastasis patients
Riebensahm, C., Joosse, S. A., Mohme, M., Hanssen, A., Matschke, J., Goy, Y., Witzel, I., Lamszus, K., Kropidlowski, J., Petersen, C., Kolb-Kokocinski, A., Sauer, S., Borgmann, K., Glatzel, M., Müller, V., Westphal, M., Riethdorf, S., Pantel, K. & Wikman, H., 03.09.2019, In: BREAST CANCER RES. 21, 1, p. 101Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cancer Stem Cells and Radioresistance: DNA Repair and Beyond
Meyer, F., Borgmann, K., Schulz, A. & Dubrovska, A., 21.06.2019, In: CANCERS. 2019, 11, p. 1-20 11060862.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity
Marcar, L., Bardhan, K., Gheorghiu, L., Dinkelborg, P., Pfäffle, H., Liu, Q., Wang, M., Piotrowska, Z., Sequist, L. V., Borgmann, K., Settleman, J. E., Engelman, J. A., Hata, A. N. & Willers, H., 18.06.2019, In: CELL REP. 27, 12, p. 3422-3432.e4Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A common Chk1-dependent phenotype of DNA double-strand break suppression in two distinct radioresistant cancer types
Dinkelborg, P. H., Wang, M., Gheorghiu, L., Gurski, J. M., Hong, T. S., Benes, C. H., Juric, D., Jimenez, R. B., Borgmann, K. & Willers, H., 04.2019, In: BREAST CANCER RES TR. 174, 3, p. 605-613 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy
Oing, C., Tennstedt, P., Simon, R., Volquardsen, J., Borgmann, K., Bokemeyer, C., Petersen, C., Dikomey, E., Rothkamm, K. & Mansour, W. Y., 01.06.2018, In: CANCER LETT. 423, p. 60-70 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects and poor outcome in patients with advanced head and neck squamous cell carcinoma
Verhagen, C. V. M., Vossen, D. M., Borgmann, K., Hageman, F., Grénman, R., Verwijs-Janssen, M., Mout, L., Kluin, R. J. C., Nieuwland, M., Severson, T. M., Velds, A., Kerkhoven, R., O'Connor, M. J., van der Heijden, M., van Velthuysen, M-L., Verheij, M., Wreesmann, V. B., Wessels, L. F. A., van den Brekel, M. W. M. & Vens, C., 06.04.2018, In: ONCOTARGET. 9, 26, p. 18198-18213 16 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer
Mansour, W. Y., Tennstedt, P., Volquardsen, J., Oing, C., Kluth, M., Hube-Magg, C., Borgmann, K., Simon, R., Petersen, C., Dikomey, E. & Rothkamm, K., 02.03.2018, In: SCI REP-UK. 8, 1, p. 3947 1 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Prevalence of fibroblast growth factor receptor 1 (FGFR1) amplification in squamous cell carcinomas of the head and neck
Clauditz, T. S., Böttcher, A., Hanken, H., Borgmann, K., Sauter, G., Wilczak, W., Grob, T. & Münscher, A., 01.2018, In: J CANCER RES CLIN. 144, 1, p. 53-61 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2017
DNA Fiber Spreading Assay to Test HDACi Effects on DNA and Its Replication
Nikolova, T., Göder, A., Parplys, A. & Borgmann, K., 2017, In: Methods Mol Biol. 1510, p. 103-113 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2016
TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress
Pai, G. M., Zielinski, A., Koalick, D., Ludwig, K., Wang, Z-Q., Borgmann, K., Pospiech, H. & Rubio, I., 20.12.2016, In: ONCOTARGET. 7, 51, p. 85365-85380Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs
Berte, N., Piée-Staffa, A., Piecha, N., Wang, M., Borgmann, K., Kaina, B. & Nikolova, T., 11.2016, In: MOL CANCER THER. 15, 11, p. 2665-2678 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci
Foertsch, F., Szambowska, A., Weise, A., Zielinski, A., Schlott, B., Kraft, F., Mrasek, K., Borgmann, K., Pospiech, H., Grosse, F. & Melle, C., 17.10.2016, In: CELL CYCLE. 15, 20, p. 2766-79 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1
Bakr, A., Köcher, S., Volquardsen, J., Petersen, C., Borgmann, K., Dikomey, E., Rothkamm, K. & Mansour Khalfallah, W. Y., 06.09.2016, In: ONCOTARGET. 7, 36, p. 57679-57693Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response
Heim, D., Gil-Ibanez, I., Herden, J., Parplys, A. C., Borgmann, K., Schmidt-Arras, D., Lohse, A. W., Rose-John, S. & Wege, H., 23.08.2016, In: ONCOTARGET. 7, 34, p. 55639-55648Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice
Bakr, A., Köcher, S., Volquardsen, J., Reimer, R., Borgmann, K., Dikomey, E., Rothkamm, K. & Mansour Khalfallah, W. Y., 05.2016, In: RADIOTHER ONCOL. 119, 2, p. 276-81 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells
Dickreuter, E., Eke, I., Krause, M., Borgmann, K., van Vugt, M. A. & Cordes, N., 17.03.2016, In: ONCOGENE. 35, 11, p. 1353-62 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response
Wurster, S., Hennes, F., Parplys, A. C., Seelbach, J. I., Mansour Khalfallah, W. Y., Zielinski, A., Petersen, C., Clauditz, T. S., Münscher, A., Friedl, A. A. & Borgmann, K., 01.03.2016, In: ONCOTARGET. 7, 9, p. 9732-41Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cdc45 is limiting for replication initiation in humans
Köhler, C., Koalick, D., Fabricius, A., Parplys, A. C., Borgmann, K., Pospiech, H. & Grosse, F., 2016, In: CELL CYCLE. 15, 7, p. 974-85 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair
Penterling, C., Drexler, G. A., Böhland, C., Stamp, R., Wilke, C., Braselmann, H., Caldwell, R. B., Reindl, J., Girst, S., Greubel, C., Siebenwirth, C., Mansour Khalfallah, W. Y., Borgmann, K., Dollinger, G., Unger, K. & Friedl, A. A., 2016, In: PLOS ONE. 11, 6, p. e0156599Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
DNA Repair
Borgmann, K., Köcher, S., Kriegs, M., Mansour Khalfallah, W. Y., Parplys, A. C., Rieckmann, T. & Rothkamm, K., 2016, Molecular Radio-Oncology. Baumann, M., Krause, M. & Cordes, N. (eds.). 1 ed. Berlin Heidelberg: Springer, Vol. 198. p. 1-24 24 p. (Recent Results in Cancer Research).Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
DNA repair after oncological therapy (radiotherapy and chemotherapy)
Dikomey, E., Borgmann, K., Kriegs, M., Mansour Khalfallah, W. Y., Petersen, C. & Rieckmann, T., 2016, Oxford Textbook of Oncology. Kerr, D. J., Haller, D. G., van de Velde, C. J. H. & Baumann, M. (eds.). 3 ed. Oxford: Oxford University Press, p. 82-85 4 p. Chapter 9Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
Radiation DNA damage and use in cancer/therapeutics-translation of radiation modifiers
Dikomey, E., Borgmann, K., Köcher, S., Kriegs, M., Mansour Khalfallah, W. Y., Parplys, A. C., Rieckmann, T. & Rothkamm, K., 2016, DNA Repair in Cancer Therapy: Molecular Targets and Clinical Applications. Kelley, M. R. & Fishel, M. L. (eds.). 2 ed. London: Elsevier Science, p. 329 - 352 23 p. Chapter11Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
- 2015
High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation
Parplys, A. C., Seelbach, J. I., Becker, S., Behr, M., Wrona, A., Jend, C., Mansour Khalfallah, W. Y., Joosse, S. A., Stuerzbecher, H-W., Pospiech, H., Petersen, C., Dikomey, E. & Borgmann, K., 02.10.2015, In: CELL CYCLE. 14, 19, p. 3190-202 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application
Salewsky, B., Hildebrand, G., Rothe, S., Parplys, A. C., Radszewski, J., Kieslich, M., Wessendorf, P., Krenzlin, H., Borgmann, K., Nussenzweig, A., Sperling, K. & Digweed, M., 12.08.2015, In: MOL THER. 24, 1, p. 117-124Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair
Srinivas, U. S., Dyczkowski, J., Beißbarth, T., Gaedcke, J., Mansour Khalfallah, W. Y., Borgmann, K. & Dobbelstein, M., 20.05.2015, In: ONCOTARGET. 6, 14, p. 12574-86 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation
Bakr, A., Oing, C., Köcher, S., Borgmann, K., Dornreiter, I., Petersen, C., Dikomey, E. & Mansour Khalfallah, W. Y., 31.03.2015, In: NUCLEIC ACIDS RES. 43, 6, p. 3154-66 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Association between SNPs in defined functional pathways and risk of early or late toxicity as well as individual radiosensitivity
Reuther, S., Szymczak, S., Raabe, A., Borgmann, K., Ziegler, A., Petersen, C., Dikomey, E. & Hoeller, U., 01.01.2015, In: STRAHLENTHER ONKOL. 191, 1, p. 59-66 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review