Prof. Dr. ID: 59947
Jörg Heeren
Publications
- 2015
Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes
Lasrich, D., Bartelt, A., Grewal, T. & Heeren, J., 10.09.2015, In: EXP CELL RES. 337, 1, p. 94-102 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control
Klünder, S., Heeren, J., Markmann, S., Santer, R., Braulke, T. & Pohl, S., 08.2015, In: J LIPID RES. 56, 8, p. 1625-32 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice
Baumeier, C., Kaiser, D., Heeren, J., Scheja, L., John, C., Weise, C., Eravci, M., Lagerpusch, M., Schulze, G., Joost, H-G., Schwenk, R. W. & Schürmann, A., 05.2015, In: Biochim Biophys Acta. 1851, 5, p. 566-76 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue
Hoffmann, L. S., Etzrodt, J., Willkomm, L., Sanyal, A., Scheja, L., Fischer, A. W. C., Stasch, J-P., Bloch, W., Friebe, A., Heeren, J. & Pfeifer, A., 05.2015, In: NAT COMMUN. 6, p. Art. 7235Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lrp1/LDL receptor play critical roles in mannose 6-phosphate-independent lysosomal enzyme targeting
Markmann, S., Thelen, M., Cornils, K., Schweizer, M., Brocke-Ahmadinejad, N., Willnow, T., Heeren, J., Gieselmann, V., Braulke, T. & Kollmann, K., 18.03.2015, In: TRAFFIC.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice
Carambia, A., Freund, B., Schwinge, D., Bruns, O. T., Salmen, S. C., Ittrich, H., Reimer, R., Heine, M., Huber, S., Waurisch, C., Eychmüller, A., Wraith, D. C., Korn, T., Nielsen, P., Weller, H., Schramm, C., Lüth, S., Lohse, A. W., Heeren, J. & Herkel, J., 21.01.2015, In: J HEPATOL. 62, 6, p. 1349-1356Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice
Bargheer, D., Giemsa, A., Freund, B., Heine, M., Waurisch, C., Stachowski, G. M., Hickey, S. G., Eychmüller, A., Heeren, J. & Nielsen, P., 09.01.2015, In: BEILSTEIN J NANOTECH. 6, p. 111-23 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The fate of a designed protein corona on nanoparticles in vitro and in vivo
Bargheer, D., Nielsen, J., Gébel, G., Heine, M., Salmen, S. C., Stauber, R., Weller, H., Heeren, J. & Nielsen, P., 06.01.2015, In: BEILSTEIN J NANOTECH. 6, p. 36-46 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
Berbée, J. F. P., Boon, M. R., Khedoe, P. P. S. J., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., Jung, C., Vazirpanah, N., Brouwers, L. P. J., Gordts, P. L. S. M., Esko, J. D., Hiemstra, P. S., Havekes, L. M., Scheja, L., Heeren, J. & Rensen, P. C. N., 2015, In: NAT COMMUN. 6, p. 6356Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity
Wagner, T., Bartelt, A., Schlein, C. & Heeren, J., 2015, In: PLOS ONE. 10, 12, e0145102.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2014
Synthesis of radioactively labelled CdSe/CdS/ZnS quantum dots for in vivo experiments
Stachowski, G. M., Bauer, C., Waurisch, C., Bargheer, D., Nielsen, P., Heeren, J., Hickey, S. G. & Eychmüller, A., 10.12.2014, In: BEILSTEIN J NANOTECH. 5, p. 2383-2387 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids
John, C., Werner, P., Worthmann, A., Wegner, K., Tödter, K., Scheja, L., Rohn, S., Heeren, J. & Fischer, M., 05.12.2014, In: J CHROMATOGR A. 1371, p. 184-195 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High density lipoprotein metabolism in low density lipoprotein receptor-deficient mice
Rinninger, F., Heine, M., Singaraja, R., Hayden, M., Brundert, M., Ramakrishnan, R. & Heeren, J., 01.09.2014, In: J LIPID RES. 55, 9, p. 1914-1924 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
TGF-β-dependent induction of CD4⁺CD25⁺Foxp3⁺ Tregs by liver sinusoidal endothelial cells
Carambia, A., Freund, B., Schwinge, D., Heine, M., Laschtowitz, A., Huber, S., Wraith, D. C., Korn, T., Schramm, C., Lohse, A. W., Heeren, J. & Herkel, J., 01.09.2014, In: J HEPATOL. 61, 3, p. 594-9 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Dichloroacetate prevents restenosis in preclinical animal models of vessel injury
Deuse, T., Hua, X., Wang, D., Maegdefessel, L., Heeren, J., Scheja, L., Bolaños, J. P., Rakovic, A., Spin, J. M., Stubbendorff, M., Ikeno, F., Länger, F., Zeller, T., Schulte-Uentrop, L., Stoehr, A., Itagaki, R., Haddad, F., Eschenhagen, T., Blankenberg, S., Kiefmann, R., Reichenspurner, H., Velden, J., Klein, C., Yeung, A., Robbins, R. C., Tsao, P. S. & Schrepfer, S., 29.05.2014, In: NATURE. 509, 7502, p. 641-644 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries
Reverter, M., Rentero, C., Garcia-Melero, A., Hoque, M., Vilà de Muga, S., Alvarez-Guaita, A., Conway, J. R. W., Wood, P., Cairns, R., Lykopoulou, L., Grinberg, D., Vilageliu, L., Bosch, M., Heeren, J., Blasi, J., Timpson, P., Pol, A., Tebar, F., Murray, R. Z., Grewal, T. & Enrich, C., 08.05.2014, In: CELL REP. 7, 3, p. 883-897 15 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity
Bartelt, A., Beil, T., Müller, B., Koehne, T., Yorgan, T. A., Heine, M., Yilmaz, T., Ruether, W., Heeren, J., Schinke, T. & Niemeier, A., 01.05.2014, In: BONE. 62, p. 90-98 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism
Oehler, N., Volz, T., Bhadra, O. D., Kah, J., Allweiss, L., Giersch, K., Bierwolf, J., Riecken, K., Pollok, J. M., Lohse, A. W., Fehse, B., Petersen, J., Urban, S., Lütgehetmann, M., Heeren, J. & Dandri, M., 08.04.2014, In: HEPATOLOGY.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant
Albers, K., Schlein, C., Wenner, K., Lohse, P., Bartelt, A., Heeren, J., Santer, R. & Merkel, M., 01.03.2014, In: ATHEROSCLEROSIS. 233, 1, p. 97-103 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Intraperitoneal Injection Improves the Uptake of Nanoparticle-Labeled High-Density Lipoprotein to Atherosclerotic Plaques Compared With Intravenous Injection: A Multimodal Imaging Study in ApoE Knockout Mice
Jung, C., Kaul, M. G., Bruns, O. T., Dučić, T., Freund, B., Heine, M., Reimer, R., Meents, A., Salmen, S. C., Weller, H., Nielsen, P., Adam, G., Heeren, J. & Ittrich, H., 01.03.2014, In: CIRC-CARDIOVASC IMAG. 7, 2, p. 303-11 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Adipose tissue browning and metabolic health
Bartelt, A. & Heeren, J., 01.01.2014, In: NAT REV ENDOCRINOL. 10, 1, p. 24-36 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Selectins mediate small cell lung cancer systemic metastasis
Heidemann, F., Schildt, A., Schmid, K., Bruns, O. T., Riecken, K., Jung, C., Ittrich, H., Wicklein, D., Reimer, R., Fehse, B., Heeren, J., Lüers, G., Schumacher, U. & Heine, M., 01.01.2014, In: PLOS ONE. 9, 4, p. e92327Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver
Heine, M., Bartelt, A., Bruns, O. T., Bargheer, D., Giemsa, A., Freund, B., Scheja, L., Waurisch, C., Eychmüller, A., Reimer, R., Weller, H., Nielsen, P. & Heeren, J., 01.01.2014, In: BEILSTEIN J NANOTECH. 5, p. 1432-1440 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2013
Effects of adipocyte lipoprotein lipase on de novo lipogenesis and white adipose tissue browning
Bartelt, A., John, C., Cherradi, M. L., Niemeier, A., Tödter, K., Heeren, J. & Scheja, L., 01.05.2013, In: BBA-MOL CELL BIOL L. 1831, 5, p. 934-42 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Novel aspects of brown adipose tissue biology
Heeren, J. & Münzberg, H., 01.03.2013, In: ENDOCRIN METAB CLIN. 42, 1, p. 89-107 19 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
Kornfeld, J-W., Baitzel, C., Könner, A. C., Nicholls, H. T., Vogt, M. C., Herrmanns, K., Scheja, L., Haumaitre, C., Wolf, A. M., Knippschild, U., Seibler, J., Cereghini, S., Heeren, J., Stoffel, M. & Brüning, J. C., 07.02.2013, In: NATURE. 494, 7435, p. 111-5 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pharmacological characterization of 1-nitrosocyclohexyl acetate, a long-acting nitroxyl donor that shows vasorelaxant and antiaggregatory effects
Donzelli, S., Fischer, G., King, B. S., Niemann, C., DuMond, J. F., Heeren, J., Wieboldt, H., Baldus, S., Gerloff, C., Eschenhagen, T., Carrier, L., Böger, R. H. & Espey, M. G., 01.02.2013, In: J PHARMACOL EXP THER. 344, 2, p. 339-47 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain
Carlo, A-S., Gustafsen, C., Mastrobuoni, G., Nielsen, M. S., Burgert, T., Hartl, D., Rohe, M., Nykjaer, A., Herz, J., Heeren, J., Kempa, S., Petersen, C. M. & Willnow, T. E., 02.01.2013, In: J NEUROSCI. 33, 1, p. 358-70 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
Eissing, L., Scherer, T., Tödter, K., Knippschild, U., Greve, J. W., Buurman, W. A., Pinnschmidt, H. O., Rensen, S. S., Wolf, A. M., Bartelt, A., Heeren, J., Buettner, C. & Scheja, L., 01.01.2013, In: NAT COMMUN. 4, p. 1528Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Inhibition of mitogen-activated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells
Mulay, V., Wood, P., Manetsch, M., Darabi, M., Cairns, R., Hoque, M., Chan, K. C., Reverter, M., Alvarez-Guaita, A., Rye, K-A., Rentero, C., Heeren, J., Enrich, C. & Grewal, T., 01.01.2013, In: PLOS ONE. 8, 4, p. e62667Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection
Helk, E., Bernin, H., Ernst, T., Ittrich, H., Jacobs, T., Heeren, J., Tacke, F., Tannich, E. & Lotter, H., 01.01.2013, In: PLOS PATHOG. 9, 1, p. e1003096Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Increased expression of transthyretin in leptin-deficient ob/ob mice is not causative for their major phenotypic abnormalities.
Rendenbach, C., Ganswindt, S., Seitz, S., Barvencik, F., Hübner, A. K., Baranowsky, A., Streichert, T., Niemeier, A., Heeren, J., Amling, M., Bartelt, A. & Schinke, T., 2013, In: J NEUROENDOCRINOL. 25, 1, p. 14-22 9 p., 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2012
A new, powerful player in lipoprotein metabolism: brown adipose tissue.
Bartelt, A., Merkel, M. & Heeren, J., 2012, In: J MOL MED. 90, 8, p. 887-893 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A simple and widely applicable method to 59Fe-radiolabel monodisperse superparamagnetic iron oxide nanoparticles for in vivo quantification studies.
Freund, B., Tromsdorf, U. I., Bruns, O. T., Heine, M., Giemsa, A., Bartelt, A., Salmen, S. C., Raabe, N., Heeren, J., Ittrich, H., Reimer, R., Hohenberg, H., Schumacher, U., Weller, H. & Nielsen, P., 2012, In: ACS NANO. 6, 8, p. 7318-7325 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice.
Gordts, P. L. S. M., Bartelt, A., Nilsson, S. K., Annaert, W., Christoffersen, C., Nielsen, L. B., Heeren, J. & Roebroek, A. J. M., 2012, In: PLOS ONE. 7, 6, p. 38330 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E.
Laatsch, A., Panteli, M., Sornsakrin, M., Hoffzimmer, B., Grewal, T. & Heeren, J., 2012, In: PLOS ONE. 7, 1, p. 29385 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.
Makrypidi, G., Damme, M., Müller-Loennies, S., Trusch, M., Schmidt, B., Schlüter, H., Heeren, J., Lübke, T., Saftig, P. & Braulke, T., 2012, In: MOL CELL BIOL. 32, 4, p. 774-782 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Nanocrystals, a new tool to study lipoprotein metabolism and atherosclerosis.
Heeren, J. & Bruns, O., 2012, In: CURR PHARM BIOTECHNO. 13, 2, p. 365-372 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.
van Rahden, V., Brand, K., Najm, J., Heeren, J., Heeren, J., Braulke, T., Kutsche, K. & Kutsche, K., 2012, In: HUM MOL GENET. 21, 23, p. 5019-5038 23.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.
Jaschke, A., Chung, B., Hesse, D., Kluge, R., Zahn, C., Moser, M., Petzke, K-J., Brigelius-Flohé, R., Puchkov, D., Koepsell, H., Heeren, J., Joost, H-G. & Schürmann, A., 2012, In: HUM MOL GENET. 21, 14, p. 3128-3142 14.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The holy grail of metabolic disease: brown adipose tissue.
Bartelt, A. & Heeren, J., 2012, In: CURR OPIN LIPIDOL. 23, 3, p. 190-195 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The role of apolipoprotein E in bone metabolism.
Niemeier, A., Schinke, T., Heeren, J. & Amling, M., 2012, In: BONE. 50, 2, p. 518-524 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Triacylglycerol-rich lipoproteins protect lipoprotein lipase from inactivation by ANGPTL3 and ANGPTL4.
Nilsson, S. K., Anderson, F., Ericsson, M., Larsson, M., Makoveichuk, E., Lookene, A., Heeren, J. & Olivecrona, G., 2012, In: Biochim Biophys Acta. 1821, 10, p. 1370-1378 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2011
Altered endocannabinoid signalling after a high-fat diet in Apoe(-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance.
Bartelt, A., Orlando, P., Mele, C., Ligresti, A., Tödter, K., Scheja, L., Heeren, J. & Di Marzo, V., 2011, In: DIABETOLOGIA. 54, 11, p. 2900-2910 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Apolipoprotein A-V; a potent triglyceride reducer.
Nilsson, S. K., Heeren, J., Olivecrona, G. & Merkel, M., 2011, In: ATHEROSCLEROSIS. 219, 1, p. 15-21 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Brown adipose tissue activity controls triglyceride clearance.
Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M., Tromsdorf, U. I., Weller, H., Waurisch, C., Eychmüller, A., Gordts, P. L. S. M., Rinninger, F., Brügelmann, K., Freund, B., Nielsen, P., Merkel, M. & Heeren, J., 2011, In: NAT MED. 17, 2, p. 200-205 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
[Energy, brown adipose tissue, obesity].
Merkel, M. & Heeren, J., 2011, In: DEUT MED WOCHENSCHR. 136, 11, p. 548-550 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication.
Cuchet, D., Sykes, A., Nicolas, A., Orr, A., Murray, J., Sirma, H., Heeren, J., Bartelt, A. & Everett, R. D., 2011, In: J CELL SCI. 124, 2, p. 280-291 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Ras/mitogen-activated protein kinase (MAPK) signaling modulates protein stability and cell surface expression of scavenger receptor SR-BI.
Wood, P., Mulay, V., Darabi, M., Chan, K. C., Heeren, J., Pol, A., Lambert, G., Rye, K-A., Enrich, C. & Grewal, T., 2011, In: J BIOL CHEM. 286, 26, p. 23077-23092 26.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Role for LAMP-2 in endosomal cholesterol transport.
Schneede, A., Schmidt, C. K., Hölttä-Vuori, M., Heeren, J., Willenborg, M., Blanz, J., Domanskyy, M., Breiden, B., Brodesser, S., Landgrebe, J., Sandhoff, K., Ikonen, E., Saftig, P. & Eskelinen, E-L., 2011, In: J CELL MOL MED. 15, 2, p. 280-295 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review