Dr. rer. nat. ID: 42443
Gabriele Loers
Publications
- 2014
Tegaserod mimics the neurostimulatory glycan polysialic acid and promotes nervous system repair.
Bushman, J., Mishra, B., Ezra, M., Gul, S., Schulze, C., Chaudhury, S., Ripoll, D., Wallqvist, A., Kohn, J., Schachner, M. & Loers, G., 04.2014, In: NEUROPHARMACOLOGY. 79, p. 456-466 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Nonyloxytryptamine mimics polysialic acid and modulates neuronal and glial functions in cell culture.
Loers, G., Saini, V., Mishra, B., Papastefanaki, F., Lutz, D., Chaudhury, S., Ripoll, D. R., Wallqvist, A., Gul, S., Schachner, M. & Kaur, G., 01.2014, In: J NEUROCHEM. 128, 1, p. 88-100 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A Fab fragment directed against the neural cell adhesion molecule L1 enhances functional recovery after injury of the adult mouse spinal cord.
Loers, G., Cui, Y-F., Neumaier, I., Schachner, M. & Skerra, A., 2014, In: BIOCHEM J. 460, 3, p. 437-446 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2013
Gold nanoparticles functionalized with a fragment of the neural cell adhesion molecule L1 stimulate L1-mediated functions.
Schulz, F., Lutz, D., Rusche, N., Bastus, N., Stieben, M., Höltig, M., Grüner, F., Weller, H., Schachner, M., Vossmeyer, T. & Loers, G., 07.11.2013, In: NANOSCALE. 5, 21, p. 10606-10617 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Dermatan 4-O-sulfotransferase1 ablation accelerates peripheral nerve regeneration.
Akyüz, N., Rost, S., Mehanna, A., Bian, S., Loers, G., Oezen, I., Mishra, B., Hoffmann, K., Guseva, D., Laczynska, E., Irintchev, A., Jakovcevski, I. & Schachner, M., 09.2013, In: EXP NEUROL. 247, p. 517-530 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Adhesion molecule L1 binds to amyloid beta and reduces Alzheimer's disease pathology in mice.
Djogo, N., Jakovcevski, I., Müller, C., Lee, H. J., Xu, J-C., Jakovcevski, M., Kügler, S., Loers, G. & Schachner, M., 08.2013, In: NEUROBIOL DIS. 56, p. 104-115 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin
Stemmer, N., Strekalova, E., Djogo, N., Plöger, F., Loers, G., Lutz, D., Buck, F., Michalak, M., Schachner, M. & Kleene, R., 01.01.2013, In: PLOS ONE. 8, 4, p. e61299Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Functional role of the interaction between polysialic acid and myristoylated alanine-rich C kinase substrate at the plasma membrane.
Theis, T., Mishra, B., von der Ohe, M., Loers, G., Prondzynski, M., Pless, O., Blackshear, P. J., Schachner, M. & Kleene, R., 2013, In: J BIOL CHEM. 288, 9, p. 6726-6742 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM).
Euteneuer, S., Yang, K. H., Chavez, E., Leichtle, A., Loers, G., Olshansky, A., Pak, K., Schachner, M. & Ryan, A. F., 2013, In: MOL CELL NEUROSCI. 54, p. 30-43Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2012
Antibody fragments directed against different portions of the human neural cell adhesion molecule L1 act as inhibitors or activators of L1 function.
Wang, Y., Loers, G., Pan, H-C., Gouveia, R., Zhao, W-J., Shen, Y-Q., Kleene, R., Costa, J. & Schachner, M., 2012, In: PLOS ONE. 7, 12, p. 52404 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Inhibition of the bacterial lectins of Pseudomonas aeruginosa with monosaccharides and peptides.
Gustke, H., Kleene, R., Loers, G., Nehmann, N., Jaehne, M., Bartels, K-M., Jaeger, K-E., Schachner, M. & Schumacher, U., 2012, In: EUR J CLIN MICROBIOL. 31, 2, p. 207-215 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Neurite outgrowth triggered by the cell adhesion molecule L1 requires activation and inactivation of the cytoskeletal protein cofilin.
Figge, C., Loers, G., Schachner, M. & Tilling, T., 2012, In: MOL CELL NEUROSCI. 49, 2, p. 196-204 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Oriented, multimeric biointerfaces of the l1 cell adhesion molecule: an approach to enhance neuronal and neural stem cell functions on 2-d and 3-d polymer substrates.
Cherry, J. F., Carlson, A. L., Benarba, F. L., Sommerfeld, S. D., Verma, D., Loers, G., Kohn, J., Schachner, M. & Moghe, P. V., 2012, In: BIOINTERPHASES. 7, 1-4, p. 22 1-4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Synthesis and molecular recognition studies of the HNK-1 trisaccharide and related oligosaccharides. The specificity of monoclonal anti-HNK-1 antibodies as assessed by surface plasmon resonance and STD NMR.
Tsvetkov, Y. E., Burg-Roderfeld, M., Loers, G., Ardá, A., Sukhova, E. V., Khatuntseva, E. A., Grachev, A. A., Chizhov, A. O., Siebert, H-C., Schachner, M., Jiménez-Barbero, J. & Nifantiev, N. E., 2012, In: J AM CHEM SOC. 134, 1, p. 426-435 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The effect of glycomimetic functionalized collagen on peripheral nerve repair.
Masand, S. N., Chen, J., Perron, I. J., Hammerling, B. C., Loers, G., Schachner, M. & Shreiber, D. I., 2012, In: BIOMATERIALS. 33, 33, p. 8353-8362 33.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The interaction between cell adhesion molecule L1, matrix metalloproteinase 14, and adenine nucleotide translocator at the plasma membrane regulates L1-mediated neurite outgrowth of murine cerebellar neurons.
Loers, G., Makhina, T., Bork, U., Dörner, A., Schachner, M. & Kleene, R., 2012, In: J NEUROSCI. 32, 11, p. 3917-3930 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2011
Dermatan sulfotransferase Chst14/D4st1, but not chondroitin sulfotransferase Chst11/C4st1, regulates proliferation and neurogenesis of neural progenitor cells.
Bian, S., Akyüz, N., Bernreuther, C., Loers, G., Laczynska, E., Jakovcevski, I. & Schachner, M., 2011, In: J CELL SCI. 124, Pt 23, p. 4051-4063 Pt 23.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Glycomimetic improves recovery after femoral injury in a non-human primate.
Irintchev, A., Wu, M-M., Lee, H. J., Zhu, H., Feng, Y-P., Liu, Y-S., Bernreuther, C., Loers, G., You, S-W. & Schachner, M., 2011, In: J NEUROTRAUM. 28, 7, p. 1295-1306 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Synapsin I is an oligomannose-carrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes.
Wang, S., Cesca, F., Loers, G., Schweizer, M., Buck, F., Benfenati, F., Schachner, M. & Kleene, R., 2011, In: J NEUROSCI. 31, 20, p. 7275-7290 20.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2010
Functional role of the interaction between polysialic acid and extracellular histone H1.
Mishra, B., von der Ohe, M., Schulze, C., Bian, S., Makhina, T., Loers, G., Kleene, R. & Schachner, M., 2010, In: J NEUROSCI. 30, 37, p. 12400-12413 37.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Polysialic acid glycomimetic promotes functional recovery and plasticity after spinal cord injury in mice.
Mehanna, A., Jakovcevski, I., Acar, A., Xiao, M., Loers, G., Rougon, G., Irintchev, A. & Schachner, M., 2010, In: MOL THER. 18, 1, p. 34-43 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The extracellular matrix glycoprotein tenascin-C is beneficial for spinal cord regeneration.
Chen, J., Lee, H. J., Jakovcevski, I., Shah, R., Bhagat, N., Loers, G., Liu, H-Y., Meiners, S., Taschenberger, G., Kügler, S., Irintchev, A. & Schachner, M., 2010, In: MOL THER. 18, 10, p. 1769-1777 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2009
Cell surface sialylation and fucosylation are regulated by the cell recognition molecule L1 via PLCgamma and cooperate to modulate embryonic stem cell survival and proliferation.
Li, Y-L., Wu, G-Z., Zeng, L., Dawe, G. S., Sun, L., Loers, G., Tilling, T., Cui, S-S., Schachner, M. & Xiao, Z-C., 2009, In: FEBS LETT. 583, 4, p. 703-710 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Extracellular GAPDH binds to L1 and enhances neurite outgrowth.
Makhina, T., Loers, G., Schulze, C., Ueberle, B., Schachner, M. & Kleene, R., 2009, In: MOL CELL NEUROSCI. 41, 2, p. 206-218 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth.
Lieberoth, A., Splittstoesser, F., Katagihallimath, N., Jakovcevski, I., Loers, G., Ranscht, B., Karagogeos, D., Schachner, M. & Kleene, R., 2009, In: J NEUROSCI. 29, 20, p. 6677-6690 20.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Polysialic acid glycomimetics promote myelination and functional recovery after peripheral nerve injury in mice.
Mehanna, A., Mishra, B., Kurschat, N., Schulze, C., Bian, S., Loers, G., Irintchev, A. & Schachner, M., 2009, In: BRAIN. 132, 6, p. 1449-1462 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2008
Cell surface sialylation and fucosylation are regulated by L1 via phospholipase Cgamma and cooperate to modulate neurite outgrowth, cell survival and migration.
Li, Y-L., Wu, G-Z., Dawe, G. S., Zeng, L., Cui, S-S., Loers, G., Tilling, T., Sun, L., Schachner, M. & Xiao, Z-C., 2008, In: PLOS ONE. 3, 12, p. 3841 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2007
Prion protein regulates glutamate-dependent lactate transport of astrocytes.
Kleene, R., Loers, G., Langer, J., Frobert, Y., Buck, F. & Schachner, M., 2007, In: J NEUROSCI. 27, 45, p. 12331-12340 45.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Recognition molecules and neural repair.
Loers, G. & Schachner, M., 2007, In: J NEUROCHEM. 101, 4, p. 865-882 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2006
Carbohydrate mimics promote functional recovery after peripheral nerve repair.
Simova, O., Irintchev, A., Mehanna, A., Liu, J., Dihné, M., Bächle, D., Sewald, N., Loers, G. & Schachner, M., 2006, In: ANN NEUROL. 60, 4, p. 430-437 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Glycomimetic cyclic peptides stimulate neurite outgrowth.
Bächle, D., Loers, G., Guthöhrlein, E. W., Schachner, M. & Sewald, N., 2006, In: ANGEW CHEM INT EDIT. 45, 39, p. 6582-6585 39.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2005
Signal transduction pathways implicated in neural recognition molecule L1 triggered neuroprotection and neuritogenesis.
Loers, G., Chen, S., Grumet, M. & Schachner, M., 2005, In: J NEUROCHEM. 92, 6, p. 1463-1476 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2004
Comparison of myelin, axon, lipid, and immunopathology in the central nervous system of differentially myelin-compromised mutant mice: a morphological and biochemical study.
Loers, G., Aboul-Enein, F., Bartsch, U., Lassmann, H. & Schachner, M., 10.2004, In: MOL CELL NEUROSCI. 27, 2, p. 175-189 15 p., 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pathology of a mouse mutation in peripheral myelin protein P0 is characteristic of a severe and early onset form of human Charcot-Marie-Tooth type 1B disorder.
Rünker, A. E., Kobsar, I., Fink, T., Loers, G., Tilling, T., Putthoff, P., Wessig, C., Martini, R. & Schachner, M., 2004, In: J CELL BIOL. 165, 4, p. 565-573 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1997
Differential Induction of Lipoxygenase Isoforms in Wheat upon Treatment with Rust Fungus Elicitor, Chitin Oligosaccharides, Chitosan, and Methyl Jasmonate.
Bohland, C., Balkenhohl, T., Loers, G., Feussner, I. & Grambow, H. J., 1997, In: Plant Physiol. 114, 2, p. 679-685 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review