Dr. rer. nat. ID: 42443
Gabriele Loers
Publications
- 2024
Mice mutated in the first fibronectin domain of adhesion molecule L1 show brain malformations and behavioral abnormalities
Granato, V., Congiu, L., Jakovcevski, I., Kleene, R., Schwindenhammer, B., Fernandes, L., Freitag, S., Schachner, M. & Loers, G., 11.04.2024, In: BIOMOLECULES. 14, 4, 468.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2023
CHL1 depletion affects dopamine receptor D2-dependent modulation of mouse behavior
Fernandes, L., Kleene, R., Congiu, L., Freitag, S., Kneussel, M., Loers, G. & Schachner, M., 09.11.2023, In: FRONT BEHAV NEUROSCI. 17, p. 1288509Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Interaction of L1CAM with LC3 Is Required for L1-Dependent Neurite Outgrowth and Neuronal Survival
Loers, G., Kleene, R., Granato, V., Bork, U. & Schachner, M., 07.08.2023, In: INT J MOL SCI. 24, 15, 12531.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mice Mutated in the Third Fibronectin Domain of L1 Show Enhanced Hippocampal Neuronal Cell Death, Astrogliosis and Alterations in Behavior
Congiu, L., Granato, V., Jakovcevski, I., Kleene, R., Fernandes, L., Freitag, S., Kneussel, M., Schachner, M. & Loers, G., 29.04.2023, In: BIOMOLECULES. 13, 5, 776.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
X-ray structure and function of fibronectin domains two and three of the neural cell adhesion molecule L1
Guédez, G., Loers, G., Jeffries, C., Kozak, S., Meijers, R., Svergun, D., Schachner, M. & Löw, C., 03.2023, In: FASEB J. 37, 3, p. e22823 e22823.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Interactions of the 70 kDa Fragment of Cell Adhesion Molecule L1 with Topoisomerase 1, Peroxisome Proliferator-Activated Receptor γ and NADH Dehydrogenase (Ubiquinone) Flavoprotein 2 Are Involved in Gene Expression and Neuronal L1-Dependent Functions
Loers, G., Kleene, R., Bork, U. & Schachner, M., 20.01.2023, In: INT J MOL SCI. 24, 3, 2097.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The KDET Motif in the Intracellular Domain of the Cell Adhesion Molecule L1 Interacts with Several Nuclear, Cytoplasmic, and Mitochondrial Proteins Essential for Neuronal Functions
Kleene, R., Loers, G. & Schachner, M., 04.01.2023, In: INT J MOL SCI. 24, 2, 932.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2022
Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model
Sun, W., Wen, M., Wang, Q., Liu, Q., Li, L., Siebert, H-C., Loers, G., Zhang, R. & Zhang, N., 01.12.2022, In: FRONT AGING NEUROSCI. 14, p. 1075161 1075161.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
HDAC3 Inhibitor RGFP966 Ameliorated Neuroinflammation in the Cuprizone-Induced Demyelinating Mouse Model and LPS-Stimulated BV2 Cells by Downregulating the P2X7R/STAT3/NF-κB65/NLRP3 Activation
Sun, W., Zhang, N., Liu, B., Yang, J., Loers, G., Siebert, H-C., Wen, M., Zheng, X., Wang, Z., Han, J. & Zhang, R., 07.09.2022, In: ACS CHEM NEUROSCI. 13, 17, p. 2579-2598 20 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice
Congiu, L., Granato, V., Loers, G., Kleene, R. & Schachner, M., 14.04.2022, In: INT J MOL SCI. 23, 8, 4337.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Cell Adhesion Molecule L1 Interacts with Methyl CpG Binding Protein 2 via Its Intracellular Domain
Loers, G., Kleene, R., Girbes Minguez, M. & Schachner, M., 24.03.2022, In: INT J MOL SCI. 23, 7, 3554.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cell adhesion molecule L1 interacts with the chromo shadow domain of heterochromatin protein 1 isoforms α, β, and ɣ via its intracellular domain
Kleene, R., Loers, G., Castillo, G. & Schachner, M., 01.2022, In: FASEB J. 36, 1, e22074.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2021
Interplay in neural functions of cell adhesion molecule close homolog of L1 (CHL1) and Programmed Cell Death 6 (PDCD6)
Loers, G., Theis, T., Baixia Hao, H., Kleene, R., Arsha, S., Samuel, N., Arsha, N., Young, W. & Schachner, M., 03.11.2021, In: FASEB BIOADV. 4, 1, p. 43-59 17 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Proteins Binding to the Carbohydrate HNK-1: Common Origins?
Castillo, G., Kleene, R., Schachner, M., Loers, G. & Torda, A. E., 29.07.2021, In: INT J MOL SCI. 22, 15, 8116.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Revisiting the proteolytic processing of cell adhesion molecule L1
Kleene, R., Lutz, D., Loers, G., Bork, U., Borgmeyer, U., Hermans-Borgmeyer, I. & Schachner, M., 05.2021, In: J NEUROCHEM. 157, 4, p. 1102-1117 16 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Amelioration of the abnormal phenotype of a new L1 syndrome mouse mutation with L1 mimetics
Loers, G., Appel, D., Lutz, D., Congiu, L., Kleene, R., Hermans-Borgmeyer, I., Schäfer, M. K. E. & Schachner, M., 02.2021, In: FASEB J. 35, 2, p. e21329Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2020
Cuprizone-Induced Demyelination in Mouse Hippocampus Is Alleviated by Ketogenic Diet.
Liu, C., Zhang, N., Zhang, R., Jin, L., Petridis, A. K., Loers, G., Zheng, X., Wang, Z. & Siebert, H-C., 07.10.2020, In: J AGR FOOD CHEM. 68, 40, p. 11215–11228Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Functions of Small Organic Compounds that Mimic the HNK-1 Glycan
Wang, M., Theis, T., Kabat, M., Loers, G., Agre, L. A. & Schachner, M., 24.09.2020, In: INT J MOL SCI. 21, 19, 7018.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet
Zhang, N., Liu, C., Zhang, R., Jin, L., Yin, X., Zheng, X., Siebert, H-C., Li, Y., Wang, Z., Loers, G. & Petridis, A. K., 09.06.2020, In: FOOD FUNCT. 11, 6, p. 5647-5663Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2019
Microscaffolds by Direct Laser Writing for Neurite Guidance Leading to Tailor-Made Neuronal Networks
Fendler, C., Denker, C., Harberts, J., Bayat, P., Zierold, R., Loers, G., Münzenberg, M. & Blick, R. H., 05.2019, In: ADV BIOSYST. 3, 5, p. e1800329Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Correction: Culturing and patch clamping of Jurkat T cells and neurons on Al2O3 coated nanowire arrays of altered morphology
Harberts, J., Zierold, R., Fendler, C., Koitmäe, A., Bayat, P., Fernandez-Cuesta, I., Loers, G., Diercks, B-P., Fliegert, R., Guse, A. H., Ronning, C., Otnes, G., Borgström, M. & Blick, R. H., 30.04.2019, In: RSC ADV. 9, 24, p. 13614Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Culturing and patch clamping of Jurkat T cells and neurons on Al2O3 coated nanowire arrays of altered morphology
Harberts, J., Zierold, R., Fendler, C., Koitmäe, A., Bayat, P., Fernandez-Cuesta, I., Loers, G., Diercks, B-P., Fliegert, R., Guse, A. H., Ronning, C., Otnes, G., Borgström, M. & Blick, R. H., 09.04.2019, In: RSC ADV. 9, 20, p. 11194-11201 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Identification and characterization of synthetic chondroitin-4-sulfate binding peptides in neuronal functions
Loers, G., Liao, Y., Hu, C., Xue, W., Shen, H., Zhao, W. & Schachner, M., 31.01.2019, In: SCI REP-UK. 9, 1, p. 1064Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Knockdown of chondroitin-4-sulfotransferase-1, but not of dermatan-4-sulfotransferase-1, accelerates regeneration of zebrafish after spinal cord injury.
Sahu, S., Li, R., Loers, G. & Schachner, M., 30.01.2019, In: FASEB J. 33, 2, p. 2252-2262Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Histone H1 improves regeneration after mouse spinal cord injury and changes shape and gene expression of cultured astrocytes
Kleene, R., Loers, G., Jakovcevski, I., Mishra, B. & Schachner, M., 2019, In: RESTOR NEUROL NEUROS. 37, 4, p. 291-313 23 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Localising functionalised gold-nanoparticles in murine spinal cords by X-ray fluorescence imaging and background-reduction through spatial filtering for human-sized objects.
Grüner, F., Blumendorf, F., Schmutzler, O., Staufer, T., Bradbury, M., Wiesner, U., Rosentreter, T., Loers, G., Lutz, D., Richter, B., Fischer, M., Schulz, F., Steiner, S., Warmer, M., Burkhardt, A., Meents, A., Kupinski, M. & Hoeschen, C., 08.11.2018, In: SCI REP-UK. 8, 1, p. 16561Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A Fragment of Adhesion Molecule L1 Binds to Nuclear Receptors to Regulate Synaptic Plasticity and Motor Coordination
Kraus, K., Kleene, R., Henis, M., Braren, I., Kataria, H., Sharaf, A., Loers, G., Schachner, M. & Lutz, D., 09.2018, In: MOL NEUROBIOL. 55, 9, p. 7164-7178Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A fragment of adhesion molecule L1 is imported into mitochondria, and regulates mitochondrial metabolism and trafficking.
Kraus, K., Kleene, R., Braren, I., Loers, G., Lutz, D. & Schachner, M., 08.05.2018, In: J CELL SCI. 131, 9, p. UNSP jcs210500Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Designer Neural Networks with Embedded Semiconductor Microtube Arrays.
Koitmäe, A., Müller, M., Bausch, C. S., Harberts, J., Hansen, W., Loers, G. & Blick, R. H., 30.01.2018, In: LANGMUIR. 34, 4, p. 1528-1534Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A Small Organic Compound Mimicking the L1 Cell Adhesion Molecule Promotes Functional Recovery after Spinal Cord Injury in Zebrafish.
Sahu, S., Zhang, Z., Li, R., Hu, J., Shen, H., Loers, G., Shen, Y. & Schachner, M., 01.2018, In: MOL NEUROBIOL. 55, 1, p. 859-878Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2017
Proteolytic cleavage of transmembrane cell adhesion molecule L1 by extracellular matrix molecule Reelin is important for mouse brain development
Lutz, D., Sharaf, A., Drexler, D., Kataria, H., Wolters-Eisfeld, G., Brunne, B., Kleene, R., Loers, G., Frotscher, M. & Schachner, M., 10.11.2017, In: SCI REP-UK. 7, 1, p. 15268Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Nuclear fragments of the neural cell adhesion molecule NCAM with or without polysialic acid differentially regulate gene expression
Westphal, N., Theis, T., Loers, G., Schachner, M. & Kleene, R., 19.10.2017, In: SCI REP-UK. 7, 1, p. 13631Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Generation and intracellular trafficking of a polysialic acid-carrying fragment of the neural cell adhesion molecule NCAM to the cell nucleus.
Westphal, N., Loers, G., Lutz, D., Theis, T., Kleene, R. & Schachner, M., 17.08.2017, In: SCI REP-UK. 7, 1, p. 8622Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The cell adhesion molecule CHL1 interacts with patched-1 to regulate neuritogenesis, neuronal cell migration and apoptosis during postnatal cerebellar development.
Katic, J., Loers, G., Tosic, J., Schachner, M. & Kleene, R., 01.08.2017, In: J CELL SCI. 130, 5, p. 2606-2619Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The polysialic acid mimetics idarubicin and irinotecan stimulate neuronal survival and neurite outgrowth and signal via protein kinase C.
Loers, G., Astafiev, S., Hapiak, Y., Saini, V., Mishra, B., Gul, S., Kaur, G., Schachner, M. & Theis, T., 08.2017, In: J NEUROCHEM. 142, 3, p. 392-406Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2016
Approaching integrated hybrid neural circuits: axon guiding on optically active semiconductor microtube arrays.
Koitmäe, A., Harberts, J., Loers, G., Müller, M., Bausch, C. S., Sonnenberg, D., Heyn, C., Zierold, R., Hansen, W. & Blick, R. H., 24.12.2016, In: ADV MATER INTERFACES. 3, 24, p. 1600746Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Small Molecule Agonists of Cell Adhesion Molecule L1 Mimic L1 Functions In Vivo.
Kataria, H., Lutz, D., Chaudhary, H., Schachner, M. & Loers, G., 15.09.2016, In: MOL NEUROBIOL. 53, 7, p. 4461-4483Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impact of neural cell adhesion molecule deletion on regeneration after mouse spinal cord injury
Saini, V., Loers, G., Kaur, G., Schachner, M. & Jakovcevski, I., 15.07.2016, In: EUR J NEUROSCI. 44, 1, p. 1734-1746Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Myelin Basic Protein Cleaves Cell Adhesion Molecule L1 and Improves Regeneration After Injury.
Lutz, D., Kataria, H., Kleene, R., Loers, G., Chaudhary, H., Guseva, D., Wu, B., Jakovcevski, I. & Schachner, M., 15.07.2016, In: MOL NEUROBIOL. 53, 5, p. 3360-3376Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair
Saini, V., Lutz, D., Kataria, H., Kaur, G., Schachner, M. & Loers, G., 21.06.2016, In: SCI REP-UK. 6, p. 1-12Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein
Guitart, K., Loers, G., Buck, F., Bork, U., Schachner, M. & Kleene, R., 06.2016, In: GLIA. 64, 6, p. 896-910 15 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides
Zhang, R., Loers, G., Schachner, M., Boelens, R., Wienk, H., Siebert, S., Eckert, T., Kraan, S., Rojas-Macias, M. A., Lütteke, T., Galuska, S. P., Scheidig, A., Petridis, A. K., Liang, S., Billeter, M., Schauer, R., Steinmeyer, J., Schröder, J-M. & Siebert, H-C., 06.05.2016, In: CHEMMEDCHEM. 11, 9, p. 990-1002Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functions.
Loers, G., Saini, V., Mishra, B., Gul, S., Chaudhury, S., Wallqvist, A., Kaur, G. & Schachner, M., 01.01.2016, In: J NEUROCHEM. 136, 1, p. 48-62Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2015
Interaction between CHL1 and serotonin receptor 2c regulates signal transduction and behavior in mice
Kleene, R., Chaudhary, H., Karl, N., Katic, J., Kotarska, A., Guitart, K., Loers, G. & Schachner, M., 15.12.2015, In: J CELL SCI. 128, 24, p. 4642-52 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Intraspinal Delivery of Polyethylene Glycol-coated Gold Nanoparticles Promotes Functional Recovery After Spinal Cord Injury.
Papastefanaki, F., Jakovcevski, I., Poulia, N., Djogo, N., Schulz, F., Martinovic, T., Ciric, D., Loers, G., Vossmeyer, T., Weller, H., Schachner, M. & Matsas, R., 25.03.2015, In: MOL THER. 23, 6, p. 993-1002Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2014
Function-Triggering Antibodies to the Adhesion Molecule L1 Enhance Recovery after Injury of the Adult Mouse Femoral Nerve
Guseva, D., Loers, G. & Schachner, M., 13.11.2014, In: PLOS ONE. 9, 11, p. e112984 11 p., journal.pone.0112984.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Interaction of the Cell Adhesion Molecule CHL1 with Vitronectin, Integrins, and the Plasminogen Activator Inhibitor-2 Promotes CHL1-Induced Neurite Outgrowth and Neuronal Migration
Katic, J., Loers, G., Kleene, R., Karl, N., Schmidt, C., Buck, F., Zmijewski, J. W., Jakovcevski, I., Preissner, K. T. & Schachner, M., 29.10.2014, In: J NEUROSCI. 34, 44, p. 14606-23 18 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Tegaserod, a small compound mimetic of polysialic acid, promotes functional recovery after spinal cord injury in mice
Pan, H-C., Shen, Y-Q., Loers, G., Jakovcevski, I. & Schachner, M., 26.09.2014, In: NEUROSCIENCE. 277, p. 356-66 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Neural Cell Activation by Phenolic Compounds from the Siberian Larch (Larix sibirica)
Loers, G., Yashunsky, D. V., Nifantiev, N. E. & Schachner, M., 25.07.2014, In: J NAT PROD. 77, 7, p. 1554-61 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Myelin basic protein cleaves cell adhesion molecule l1 and promotes neuritogenesis and cell survival.
Lutz, D., Loers, G., Kleene, R., Oezen, I., Kataria, H., Katagihallimath, N., Braren, I., Harauz, G. & Schachner, M., 05.2014, In: J BIOL CHEM. 289, 19, p. 13503-13518 16 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review