Carbohydrate mimics promote functional recovery after peripheral nerve repair.

  • Olga Simova
  • Andrey Irintchev
  • Ali Mehanna
  • Jiankun Liu
  • Marcel Dihné
  • Dirk Bächle
  • Norbert Sewald
  • Gabriele Loers
  • Melitta Schachner

Abstract

The outcome of peripheral nerve repair is often unsatisfactory, and efficient therapies are not available. We tested the therapeutic potential of functional mimics of the human natural killer cell glycan (3-sulfoglucuronyl beta1-3 galactoside) (HNK-1) epitope, a carbohydrate indicated to favor specificity of motor reinnervation in mice.

Bibliographical data

Original languageGerman
Article number4
ISSN0364-5134
Publication statusPublished - 2006
pubmed 16958115