Institute of Synaptic Neuroscience
Publications
- 2019
Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics
Yizhar, O. & Wiegert, J. S., 06.2019, In: TRENDS PHARMACOL SCI. 40, 6, p. 362-364 3 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
High-speed imaging of glutamate release with genetically encoded sensors
Dürst, C. D., Wiegert, J. S., Helassa, N., Kerruth, S., Coates, C., Schulze, C., Geeves, M. A., Török, K. & Oertner, T. G., 05.2019, In: NAT PROTOC. 14, 5, p. 1401-1424 24 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The kinetic mechanisms of fast-decay red-fluorescent genetically encoded calcium indicators
Kerruth, S., Coates, C., Dürst, C. D., Oertner, T. G. & Török, K., 15.03.2019, In: J BIOL CHEM. 294, 11, p. 3934-3946 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Improved methods for marking active neuron populations
Moeyaert, B., Holt, G., Madangopal, R., Perez-Alvarez, A., Fearey, B. C., Trojanowski, N. F., Ledderose, J., Zolnik, T. A., Das, A., Patel, D., Brown, T. A., Sachdev, R. N. S., Eickholt, B. J., Larkum, M. E., Turrigiano, G. G., Dana, H., Gee, C. E., Oertner, T. G., Hope, B. T. & Schreiter, E. R., 25.10.2018, In: NAT COMMUN. 9, 1, p. 4440Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The fate of hippocampal synapses depends on the sequence of plasticity-inducing events
Wiegert, J. S., Pulin, M., Gee, C. E. & Oertner, T. G., 12.10.2018, In: ELIFE. 7, p. e39151Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior
Gromova, K. V., Muhia, M., Rothammer, N., Gee, C. E., Thies, E., Schaefer, I., Kress, S., Kilimann, M. W., Shevchuk, O., Oertner, T. G. & Kneussel, M., 29.05.2018, In: CELL REP. 23, 9, p. 2705-2717 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
Scheib, U., Broser, M., Constantin, O. M., Yang, S., Gao, S., Mukherjee, S., Stehfest, K., Nagel, G., Gee, C. E. & Hegemann, P., 24.05.2018, In: NAT COMMUN. 9, 1, p. 2046Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses
Helassa, N., Dürst, C. D., Coates, C., Kerruth, S., Arif, U., Schulze, C., Wiegert, J. S., Geeves, M., Oertner, T. G. & Török, K., 22.05.2018, In: P NATL ACAD SCI USA. 115, 21, p. 5594-5599 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Author Correction: Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior
Wietek, J., Rodriguez-Rozada, S., Tutas, J., Tenedini, F., Grimm, C., Oertner, T. G., Soba, P., Hegemann, P. & Wiegert, J. S., 14.03.2018, In: SCI REP-UK. 8, 1, p. 4765Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Synthetic Light-Activated Ion Channels for Optogenetic Activation and Inhibition
Beck, S., Yu-Strzelczyk, J., Pauls, D., Constantin, O. M., Gee, C. E., Ehmann, N., Kittel, R. J., Nagel, G. & Gao, S., 2018, In: FRONT NEUROSCI-SWITZ. 12, p. 643Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2017
Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior
Wietek, J., Rodriguez-Rozada, S., Tutas, J., Tenedini, F., Grimm, C., Oertner, T. G., Soba, P., Hegemann, P. & Wiegert, J. S., 02.11.2017, In: SCI REP-UK. 7, 1, p. 14957Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B
Wroblewski, M., Bauer, R., Cubas Córdova, M., Udonta, F., Ben-Batalla, I., Legler, K., Hauser, C., Egberts, J., Janning, M., Velthaus, J., Schulze, C., Pantel, K., Bokemeyer, C. & Loges, S., 16.08.2017, In: NAT COMMUN. 8, 1, p. 269Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Silencing Neurons: Tools, Applications, and Experimental Constraints
Wiegert, J. S., Mahn, M., Prigge, M., Printz, Y. & Yizhar, O., 02.08.2017, In: NEURON. 95, 3, p. 504-529 26 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks
Bitzenhofer, S. H., Ahlbeck, J., Wolff, A., Wiegert, J. S., Gee, C. E., Oertner, T. G. & Hanganu-Opatz, I. L., 20.02.2017, In: NAT COMMUN. 8, p. 14563Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Sex-dependent regulation of aromatase-mediated synaptic plasticity in the basolateral amygdala
Bender, R. A., Zhou, L., Vierk, R., Brandt, N., Keller, A., Gee, C. E., Schäfer, M. K. E. & Rune, G. M., 08.02.2017, In: J NEUROSCI. 37, 6, p. 1532-1545Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Preparation of Slice Cultures from Rodent Hippocampus
Gee, C. E., Ohmert, I., Wiegert, J. S. & Oertner, T. G., 01.02.2017, In: Cold Spring Harbor protocols. 2017, 2, p. pdb.prot094888Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Single-Cell Electroporation of Neurons
Wiegert, J. S., Gee, C. E. & Oertner, T. G., 01.02.2017, In: Cold Spring Harbor protocols. 2017, 2, p. pdb.prot094904Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Stimulating Neurons with Heterologously Expressed Light-Gated Ion Channels
Wiegert, J. S., Gee, C. E. & Oertner, T. G., 01.02.2017, In: Cold Spring Harbor protocols. 2017, 2, p. pdb.top089714Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Viral Vector-Based Transduction of Slice Cultures
Wiegert, J. S., Gee, C. E. & Oertner, T. G., 01.02.2017, In: Cold Spring Harbor protocols. 2017, 2, p. pdb.prot094896Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I
Fernandez, A. M., Hernandez-Garzón, E., Perez-Domper, P., Perez-Alvarez, A., Mederos, S., Matsui, T., Santi, A., Trueba-Saiz, A., García-Guerra, L., Pose-Utrilla, J., Fielitz, J., Olson, E. N., Fernandez de la Rosa, R., Garcia Garcia, L., Pozo, M. A., Iglesias, T., Araque, A., Soya, H., Perea, G., Martin, E. D. & Torres Aleman, I., 01.2017, In: DIABETES. 66, 1, p. 64-74 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2016
Active cortical dendrites modulate perception
Takahashi, N., Oertner, T. G., Hegemann, P. & Larkum, M. E., 23.12.2016, In: SCIENCE. 354, 6319, p. 1587-1590 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The insulin-like growth factor I receptor regulates glucose transport by astrocytes
Hernandez-Garzón, E., Fernandez, A. M., Perez-Alvarez, A., Genis, L., Bascuñana, P., Fernandez de la Rosa, R., Delgado, M., Angel Pozo, M., Moreno, E., McCormick, P. J., Santi, A., Trueba-Saiz, A., Garcia-Caceres, C., Tschöp, M. H., Araque, A., Martin, E. D. & Torres Aleman, I., 11.2016, In: GLIA. 64, 11, p. 1962-71 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
DFG Forschergruppe FOR 2419 „Plastizität versus Stabilität: Molekulare Mechanismen der Synapsenstärke"
Kneussel, M. & Oertner, T., 01.06.2016, In: NEUROFORUM. 22, 2, p. 60-61Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
How (not) to silence long-range projections with light
Wiegert, J. S. & Oertner, T. G., 04.2016, In: NAT NEUROSCI. 19, 4, p. 527-8 2 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Neurobiology: Pull out the stops for plasticity
Gee, C. E. & Oertner, T. G., 14.01.2016, In: NATURE. 529, 7585, p. 164-5 2 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
- 2015
Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs)
Behnke, D., Cotesta, S., Hintermann, S., Fendt, M., Gee, C. E., Jacobson, L. H., Laue, G., Meyer, A., Wagner, T., Badiger, S., Chaudhari, V., Chebrolu, M., Pandit, C., Hoyer, D. & Betschart, C., 01.12.2015, In: BIOORG MED CHEM LETT. 25, 23, p. 5555-5560Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo
Wietek, J., Beltramo, R., Scanziani, M., Hegemann, P., Oertner, T. G. & Simon Wiegert, J., 07.10.2015, In: SCI REP-UK. 5, p. 14807Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Neighborly synapses help each other out
Wiegert, S. & Oertner, T. G., 24.02.2015, In: NAT NEUROSCI. 18, 3, p. 326-7Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Automated analysis of spine dynamics on live CA1 pyramidal cells
Blumer, C., Vivien, C., Genoud, C., Perez-Alvarez, A., Wiegert, S., Vetter, T. & Oertner, T. G., 01.2015, In: MED IMAGE ANAL. 19, 1, p. 87-97 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling
Scheib, U., Stehfest, K., Gee, C. E., Körschen, H. G., Fudim, R., Oertner, T. G. & Hegemann, P., 2015, In: SCI SIGNAL. 8, 389, p. rs8Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2014
Structural and functional plasticity of astrocyte processes and dendritic spine interactions
Perez-Alvarez, A., Navarrete, M., Covelo, A., Martin, E. D. & Araque, A., 17.09.2014, In: J NEUROSCI. 34, 38, p. 12738-44 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Conversion of channelrhodopsin into a light-gated chloride channel
Wietek, J., Wiegert, J. S., Adeishvili, N., Schneider, F., Watanabe, H., Tsunoda, S. P., Vogt, A., Elstner, M., Oertner, T. G. & Hegemann, P., 25.04.2014, In: SCIENCE. 344, 6182, p. 409-12 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior
Gee, C. E., Peterlik, D., Neuhäuser, C., Bouhelal, R., Kaupmann, K., Laue, G., Uschold-Schmidt, N., Feuerbach, D., Zimmermann, K., Ofner, S., Cryan, J. F., van der Putten, H., Fendt, M., Vranesic, I., Glatthar, R. & Flor, P. J., 18.04.2014, In: J BIOL CHEM. 289, 16, p. 10975-87 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Active dendrites under parental supervision
Oertner, T., 19.03.2014, In: NEURON. 81, 6, p. 1217-1219 3 p., 24656245.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Imaging of molecular surface dynamics in brain slices using single-particle tracking
Biermann, B., Sokoll, S., Klueva, J., Missler, M., Wiegert, S., Sibarita, J-B. & Heine, M., 01.01.2014, In: NAT COMMUN. 5, p. 3024Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2013
Long-term depression triggers the selective elimination of weakly integrated synapses
Wiegert, J. S. & Oertner, T. G., 19.11.2013, In: P NATL ACAD SCI USA. 110, 47, p. E4510-9Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Astrocyte-neuron interaction at tripartite synapses
Araque, A. & Perez-Alvarez, A., 01.10.2013, In: CURR DRUG TARGETS. 14, 11, p. 1220-1224Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Developmental refinement of vesicle cycling at Schaffer collateral synapses
Rose, T., Schoenenberger, P., Jezek, K. & Oertner, T. G., 20.03.2013, In: NEURON. 77, 6, p. 1109-21 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Confocal microscopy for astrocyte in vivo imaging: Recycle and reuse in microscopy
Pérez-Alvarez, A., Araque, A. & Martín, E. D., 01.01.2013, In: FRONT CELL NEUROSCI. 7, p. 1-10 51.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Distinct effects of IPSU and suvorexant on mouse sleep architecture
Hoyer, D., Dürst, T., Fendt, M., Jacobson, L. H., Betschart, C., Hintermann, S., Behnke, D., Cotesta, S., Laue, G., Ofner, S., Legangneux, E. & Gee, C. E., 01.01.2013, In: FRONT HUM NEUROSCI. 7, p. 235 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology.
Fendt, M., Imobersteg, S., Peterlik, D., Chaperon, F., Mattes, C., Wittmann, C., Olpe, H-R., Mosbacher, J., Vranesic, I., van der Putten, H., McAllister, K. H., Flor, P. J. & Gee, C. E., 2013, In: NEUROPHARMACOLOGY. 72, p. 215-223 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Optogenetic analysis of mammalian neural circuits
Oertner, T., Helmchen, F., de Lecea, L., Beck, H., Konnerth, A., Benjamin, K., Yawo, H., Knöpfel, T. & Hausser, M., 2013, Optogenetics . Hegemann, P. & Sigrist, S. (eds.). Dahlem Workshop Reports ed. Berlin: De Gryter, p. 109-126 17 p. 10. (Dahlem Workshop Reports).Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research
- 2012
If you don't look, you won't see: intravital multiphoton imaging of primary and metastatic breast cancer.
Bonapace, L., Wyckoff, J., Oertner, T. G., Jacco, V. R., Junt, T. & Bentires-Alj, M., 01.06.2012, In: J MAMMARY GLAND BIOL. 17, 2, p. 125-129 5 p., 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Depolarization gates spine calcium transients and spike-timing-dependent potentiation.
Hao, J. & Oertner, T. G., 2012, In: CURR OPIN NEUROBIOL. 22, 3, p. 509-515 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Gastrin-releasing peptide signaling plays a limited and subtle role in amygdala physiology and aversive memory.
Chaperon, F., Fendt, M., Kelly, P. H., Lingenhoehl, K., Mosbacher, J., Olpe, H-R., Schmid, P., Sturchler, C., McAllister, K. H., Putten, V. D. & Gee, C. E., 2012, In: PLOS ONE. 7, 4, p. 1-11 34963.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Multiple dynamic representations in the motor cortex during sensorimotor learning.
Huber, D., Gutnisky, D. A., Peron, S., O'Connor, D. H., Wiegert, J. S., Tian, L., Oertner, T. G., Looger, L. L. & Svoboda, K., 2012, In: NATURE. 484, 7395, p. 473-478 7395.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Native α6β4* nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland.
Perez-Alvarez, A., Hernández-Vivanco, A., McIntosh, J. M. & Albillos, A., 2012, In: FASEB J. 26, 1, p. 346-354 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pharmacological characterization of native α7 nicotinic ACh receptors and their contribution to depolarization-elicited exocytosis in human chromaffin cells.
Perez-Alvarez, A., Hernández-Vivanco, A., Sergio, A. Y. G., Tabernero, A., McIntosh, J. M. & Albillos, A., 2012, In: BRIT J PHARMACOL. 165, 4, p. 908-921 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Selectivity of action of pregabalin on Ca(2+) channels but not on fusion pore, exocytotic machinery, or mitochondria in chromaffin cells of the adrenal gland.
Hernández-Vivanco, A., Perez-Alvarez, A., Caba-González, J. C., Alonso, M. T., Moreno-Ortega, A. J., Cano-Abad, M., Ruiz-Nuño, A., Carmona-Hidalgo, B. & Albillos, A., 2012, In: J PHARMACOL EXP THER. 342, 2, p. 263-272 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.
Mang, G. M., Dürst, T., Bürki, H., Imobersteg, S., Abramowski, D., Schuepbach, E., Hoyer, D., Fendt, M. & Gee, C. E., 2012, In: SLEEP. 35, 12, p. 1625-1635 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review