Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics
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Abstract
Chemogenetic techniques allow selective manipulation of neurons by activating engineered actuator proteins with otherwise inert effector molecules. A recent study (Magnus et al. Science 2019;364:eaav5282) describes the coevolution of highly potent actuator-effector pairs based on a clinically approved antismoking drug. These tools allow selective excitation or inhibition of neurons in the living brain with high specificity and no detectable side-effects.
Bibliographical data
Original language | English |
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ISSN | 0165-6147 |
DOIs | |
Publication status | Published - 06.2019 |
Comment Deanary
Editorial Material
PubMed | 31072638 |
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