Villin expression in human tumors: a tissue microarray study on 14,398 tumors
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Villin expression in human tumors: a tissue microarray study on 14,398 tumors. / Dum, David; Lennartz, Maximilian; Menz, Anne; Kluth, Martina; Hube-Magg, Claudia; Weidemann, Sören; Fraune, Christoph; Luebke, Andreas M; Hornsteiner, Lisa; Bernreuther, Christian; Simon, Ronald; Clauditz, Till S; Sauter, Guido; Uhlig, Ria; Hinsch, Andrea; Kind, Simon; Jacobsen, Frank; Möller, Katharina; Wilczak, Waldemar; Steurer, Stefan; Minner, Sarah; Burandt, Eike; Marx, Andreas H; Krech, Till; Lebok, Patrick.
in: EXPERT REV MOL DIAGN, Jahrgang 22, Nr. 6, 06.2022, S. 665-675.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Villin expression in human tumors: a tissue microarray study on 14,398 tumors
AU - Dum, David
AU - Lennartz, Maximilian
AU - Menz, Anne
AU - Kluth, Martina
AU - Hube-Magg, Claudia
AU - Weidemann, Sören
AU - Fraune, Christoph
AU - Luebke, Andreas M
AU - Hornsteiner, Lisa
AU - Bernreuther, Christian
AU - Simon, Ronald
AU - Clauditz, Till S
AU - Sauter, Guido
AU - Uhlig, Ria
AU - Hinsch, Andrea
AU - Kind, Simon
AU - Jacobsen, Frank
AU - Möller, Katharina
AU - Wilczak, Waldemar
AU - Steurer, Stefan
AU - Minner, Sarah
AU - Burandt, Eike
AU - Marx, Andreas H
AU - Krech, Till
AU - Lebok, Patrick
PY - 2022/6
Y1 - 2022/6
N2 - BACKGROUND: Villin is a protein of the brush border of epithelial cells, which is used as an immunohistochemical marker for colorectal and gastrointestinal neoplasms. However, other tumor entities can also express villin.METHODS: To comprehensively determine villin expression, tissue microarrays containing 14,398 samples from 118 different tumor types as well as 608 samples of 76 different normal tissues were analyzed by immunohistochemistry.RESULTS: Villin was found in 54 of 118 tumor categories, including 36 tumor categories with strong staining. Villin expression was frequent in colorectal (60-100%), upper gastrointestinal tract (61-100%), pancreatobiliary (25-86%), and renal tumors (≤18%) as well as in mucinous ovarian cancers (67%), yolk sac tumors (76%) and in neuroendocrine neoplasms (22-41%). Reduced villin expression was linked to advanced pT stage, lymph vessel invasion, and microsatellite instability (p ≤ 0.0006) in colorectal adenocarcinoma.CONCLUSION: Our data support a high utility of villin immunohistochemistry for the identification of tumors with gastrointestinal, pancreatobiliary, and yolk sac tumor origin. However, considering that at least a weak villin positivity in some tumor cells occurred in 54 different tumor categories, villin immunohistochemistry should be applied as a part of a marker panel rather than as a stand-alone marker.
AB - BACKGROUND: Villin is a protein of the brush border of epithelial cells, which is used as an immunohistochemical marker for colorectal and gastrointestinal neoplasms. However, other tumor entities can also express villin.METHODS: To comprehensively determine villin expression, tissue microarrays containing 14,398 samples from 118 different tumor types as well as 608 samples of 76 different normal tissues were analyzed by immunohistochemistry.RESULTS: Villin was found in 54 of 118 tumor categories, including 36 tumor categories with strong staining. Villin expression was frequent in colorectal (60-100%), upper gastrointestinal tract (61-100%), pancreatobiliary (25-86%), and renal tumors (≤18%) as well as in mucinous ovarian cancers (67%), yolk sac tumors (76%) and in neuroendocrine neoplasms (22-41%). Reduced villin expression was linked to advanced pT stage, lymph vessel invasion, and microsatellite instability (p ≤ 0.0006) in colorectal adenocarcinoma.CONCLUSION: Our data support a high utility of villin immunohistochemistry for the identification of tumors with gastrointestinal, pancreatobiliary, and yolk sac tumor origin. However, considering that at least a weak villin positivity in some tumor cells occurred in 54 different tumor categories, villin immunohistochemistry should be applied as a part of a marker panel rather than as a stand-alone marker.
KW - Adenocarcinoma/metabolism
KW - Biomarkers, Tumor
KW - Carrier Proteins/metabolism
KW - Colorectal Neoplasms
KW - Humans
KW - Microfilament Proteins/genetics
U2 - 10.1080/14737159.2022.2104122
DO - 10.1080/14737159.2022.2104122
M3 - SCORING: Journal article
C2 - 35866621
VL - 22
SP - 665
EP - 675
JO - EXPERT REV MOL DIAGN
JF - EXPERT REV MOL DIAGN
SN - 1473-7159
IS - 6
ER -