Research ExplorerPublicationsVillin expression in human tumors: a tissue microarray study...

Villin expression in human tumors: a tissue microarray study on 14,398 tumors

Standard

Villin expression in human tumors: a tissue microarray study on 14,398 tumors. / Dum, David; Lennartz, Maximilian; Menz, Anne; Kluth, Martina; Hube-Magg, Claudia; Weidemann, Sören; Fraune, Christoph; Luebke, Andreas M; Hornsteiner, Lisa; Bernreuther, Christian; Simon, Ronald; Clauditz, Till S; Sauter, Guido; Uhlig, Ria; Hinsch, Andrea; Kind, Simon; Jacobsen, Frank; Möller, Katharina; Wilczak, Waldemar; Steurer, Stefan; Minner, Sarah; Burandt, Eike; Marx, Andreas H; Krech, Till; Lebok, Patrick.

In: EXPERT REV MOL DIAGN, Vol. 22, No. 6, 06.2022, p. 665-675.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dum, D, Lennartz, M, Menz, A, Kluth, M, Hube-Magg, C, Weidemann, S, Fraune, C, Luebke, AM, Hornsteiner, L, Bernreuther, C, Simon, R, Clauditz, TS, Sauter, G, Uhlig, R, Hinsch, A, Kind, S, Jacobsen, F, Möller, K, Wilczak, W, Steurer, S, Minner, S, Burandt, E, Marx, AH, Krech, T & Lebok, P 2022, 'Villin expression in human tumors: a tissue microarray study on 14,398 tumors', EXPERT REV MOL DIAGN, vol. 22, no. 6, pp. 665-675. https://doi.org/10.1080/14737159.2022.2104122

APA

Dum, D., Lennartz, M., Menz, A., Kluth, M., Hube-Magg, C., Weidemann, S., Fraune, C., Luebke, A. M., Hornsteiner, L., Bernreuther, C., Simon, R., Clauditz, T. S., Sauter, G., Uhlig, R., Hinsch, A., Kind, S., Jacobsen, F., Möller, K., Wilczak, W., ... Lebok, P. (2022). Villin expression in human tumors: a tissue microarray study on 14,398 tumors. EXPERT REV MOL DIAGN, 22(6), 665-675. https://doi.org/10.1080/14737159.2022.2104122

Vancouver

Dum D, Lennartz M, Menz A, Kluth M, Hube-Magg C, Weidemann S et al. Villin expression in human tumors: a tissue microarray study on 14,398 tumors. EXPERT REV MOL DIAGN. 2022 Jun;22(6):665-675. https://doi.org/10.1080/14737159.2022.2104122

Bibtex

@article{736bc05bd2dd477183350ffe79e7e127,
title = "Villin expression in human tumors: a tissue microarray study on 14,398 tumors",
abstract = "BACKGROUND: Villin is a protein of the brush border of epithelial cells, which is used as an immunohistochemical marker for colorectal and gastrointestinal neoplasms. However, other tumor entities can also express villin.METHODS: To comprehensively determine villin expression, tissue microarrays containing 14,398 samples from 118 different tumor types as well as 608 samples of 76 different normal tissues were analyzed by immunohistochemistry.RESULTS: Villin was found in 54 of 118 tumor categories, including 36 tumor categories with strong staining. Villin expression was frequent in colorectal (60-100%), upper gastrointestinal tract (61-100%), pancreatobiliary (25-86%), and renal tumors (≤18%) as well as in mucinous ovarian cancers (67%), yolk sac tumors (76%) and in neuroendocrine neoplasms (22-41%). Reduced villin expression was linked to advanced pT stage, lymph vessel invasion, and microsatellite instability (p ≤ 0.0006) in colorectal adenocarcinoma.CONCLUSION: Our data support a high utility of villin immunohistochemistry for the identification of tumors with gastrointestinal, pancreatobiliary, and yolk sac tumor origin. However, considering that at least a weak villin positivity in some tumor cells occurred in 54 different tumor categories, villin immunohistochemistry should be applied as a part of a marker panel rather than as a stand-alone marker.",
keywords = "Adenocarcinoma/metabolism, Biomarkers, Tumor, Carrier Proteins/metabolism, Colorectal Neoplasms, Humans, Microfilament Proteins/genetics",
author = "David Dum and Maximilian Lennartz and Anne Menz and Martina Kluth and Claudia Hube-Magg and S{\"o}ren Weidemann and Christoph Fraune and Luebke, {Andreas M} and Lisa Hornsteiner and Christian Bernreuther and Ronald Simon and Clauditz, {Till S} and Guido Sauter and Ria Uhlig and Andrea Hinsch and Simon Kind and Frank Jacobsen and Katharina M{\"o}ller and Waldemar Wilczak and Stefan Steurer and Sarah Minner and Eike Burandt and Marx, {Andreas H} and Till Krech and Patrick Lebok",
year = "2022",
month = jun,
doi = "10.1080/14737159.2022.2104122",
language = "English",
volume = "22",
pages = "665--675",
journal = "EXPERT REV MOL DIAGN",
issn = "1473-7159",
publisher = "Expert Reviews Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Villin expression in human tumors: a tissue microarray study on 14,398 tumors

AU - Dum, David

AU - Lennartz, Maximilian

AU - Menz, Anne

AU - Kluth, Martina

AU - Hube-Magg, Claudia

AU - Weidemann, Sören

AU - Fraune, Christoph

AU - Luebke, Andreas M

AU - Hornsteiner, Lisa

AU - Bernreuther, Christian

AU - Simon, Ronald

AU - Clauditz, Till S

AU - Sauter, Guido

AU - Uhlig, Ria

AU - Hinsch, Andrea

AU - Kind, Simon

AU - Jacobsen, Frank

AU - Möller, Katharina

AU - Wilczak, Waldemar

AU - Steurer, Stefan

AU - Minner, Sarah

AU - Burandt, Eike

AU - Marx, Andreas H

AU - Krech, Till

AU - Lebok, Patrick

PY - 2022/6

Y1 - 2022/6

N2 - BACKGROUND: Villin is a protein of the brush border of epithelial cells, which is used as an immunohistochemical marker for colorectal and gastrointestinal neoplasms. However, other tumor entities can also express villin.METHODS: To comprehensively determine villin expression, tissue microarrays containing 14,398 samples from 118 different tumor types as well as 608 samples of 76 different normal tissues were analyzed by immunohistochemistry.RESULTS: Villin was found in 54 of 118 tumor categories, including 36 tumor categories with strong staining. Villin expression was frequent in colorectal (60-100%), upper gastrointestinal tract (61-100%), pancreatobiliary (25-86%), and renal tumors (≤18%) as well as in mucinous ovarian cancers (67%), yolk sac tumors (76%) and in neuroendocrine neoplasms (22-41%). Reduced villin expression was linked to advanced pT stage, lymph vessel invasion, and microsatellite instability (p ≤ 0.0006) in colorectal adenocarcinoma.CONCLUSION: Our data support a high utility of villin immunohistochemistry for the identification of tumors with gastrointestinal, pancreatobiliary, and yolk sac tumor origin. However, considering that at least a weak villin positivity in some tumor cells occurred in 54 different tumor categories, villin immunohistochemistry should be applied as a part of a marker panel rather than as a stand-alone marker.

AB - BACKGROUND: Villin is a protein of the brush border of epithelial cells, which is used as an immunohistochemical marker for colorectal and gastrointestinal neoplasms. However, other tumor entities can also express villin.METHODS: To comprehensively determine villin expression, tissue microarrays containing 14,398 samples from 118 different tumor types as well as 608 samples of 76 different normal tissues were analyzed by immunohistochemistry.RESULTS: Villin was found in 54 of 118 tumor categories, including 36 tumor categories with strong staining. Villin expression was frequent in colorectal (60-100%), upper gastrointestinal tract (61-100%), pancreatobiliary (25-86%), and renal tumors (≤18%) as well as in mucinous ovarian cancers (67%), yolk sac tumors (76%) and in neuroendocrine neoplasms (22-41%). Reduced villin expression was linked to advanced pT stage, lymph vessel invasion, and microsatellite instability (p ≤ 0.0006) in colorectal adenocarcinoma.CONCLUSION: Our data support a high utility of villin immunohistochemistry for the identification of tumors with gastrointestinal, pancreatobiliary, and yolk sac tumor origin. However, considering that at least a weak villin positivity in some tumor cells occurred in 54 different tumor categories, villin immunohistochemistry should be applied as a part of a marker panel rather than as a stand-alone marker.

KW - Adenocarcinoma/metabolism

KW - Biomarkers, Tumor

KW - Carrier Proteins/metabolism

KW - Colorectal Neoplasms

KW - Humans

KW - Microfilament Proteins/genetics

U2 - 10.1080/14737159.2022.2104122

DO - 10.1080/14737159.2022.2104122

M3 - SCORING: Journal article

C2 - 35866621

VL - 22

SP - 665

EP - 675

JO - EXPERT REV MOL DIAGN

JF - EXPERT REV MOL DIAGN

SN - 1473-7159

IS - 6

ER -