Treatment response of CNS high-grade neuroepithelial tumors with MN1 alteration
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Treatment response of CNS high-grade neuroepithelial tumors with MN1 alteration. / Baroni, Lorena V; Rugilo, Carlos; Lubieniecki, Fabiana; Sampor, Claudia; Freytes, Candela; Nobre, Liana; Hansford, Jordan R; Malalasekera, Vajiranee S; Zapotocky, Michal; Dodgshun, Andrew; Martinez, Ofelia Cruz; La Madrid, Andres Morales; Lavarino, Cinzia; Suñol, Mariona; Rutkowski, Stefan; Schuller, Ulrich; Bouffet, Eric; Ramaswamy, Vijay; Alderete, Daniel.
in: PEDIATR BLOOD CANCER, Jahrgang 67, Nr. 12, 12.2020, S. e28627.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Treatment response of CNS high-grade neuroepithelial tumors with MN1 alteration
AU - Baroni, Lorena V
AU - Rugilo, Carlos
AU - Lubieniecki, Fabiana
AU - Sampor, Claudia
AU - Freytes, Candela
AU - Nobre, Liana
AU - Hansford, Jordan R
AU - Malalasekera, Vajiranee S
AU - Zapotocky, Michal
AU - Dodgshun, Andrew
AU - Martinez, Ofelia Cruz
AU - La Madrid, Andres Morales
AU - Lavarino, Cinzia
AU - Suñol, Mariona
AU - Rutkowski, Stefan
AU - Schuller, Ulrich
AU - Bouffet, Eric
AU - Ramaswamy, Vijay
AU - Alderete, Daniel
N1 - © 2020 Wiley Periodicals LLC.
PY - 2020/12
Y1 - 2020/12
N2 - Central nervous system high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1) is a rare recently described entity. Fourteen CNS HGNET-MN1 patients were identified using genome-wide methylation arrays/RT-PCR across seven institutions. All patients had surgery (gross total resection: 10; subtotal resection: four) as initial management followed by observation alone in three patients, followed by radiotherapy in eight patients (focal: five; craniospinal: two; CyberKnife: one) and systemic chemotherapy in three patients. Seven patients relapsed; five local and two metastatic, despite adjuvant radiotherapy, of which three died. Treatment of CNS HGNET-MN1 remains a major treatment challenge despite aggressive surgical resections and upfront radiotherapy, warranting new approaches to this rare malignancy.
AB - Central nervous system high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1) is a rare recently described entity. Fourteen CNS HGNET-MN1 patients were identified using genome-wide methylation arrays/RT-PCR across seven institutions. All patients had surgery (gross total resection: 10; subtotal resection: four) as initial management followed by observation alone in three patients, followed by radiotherapy in eight patients (focal: five; craniospinal: two; CyberKnife: one) and systemic chemotherapy in three patients. Seven patients relapsed; five local and two metastatic, despite adjuvant radiotherapy, of which three died. Treatment of CNS HGNET-MN1 remains a major treatment challenge despite aggressive surgical resections and upfront radiotherapy, warranting new approaches to this rare malignancy.
U2 - 10.1002/pbc.28627
DO - 10.1002/pbc.28627
M3 - SCORING: Journal article
C2 - 32959992
VL - 67
SP - e28627
JO - PEDIATR BLOOD CANCER
JF - PEDIATR BLOOD CANCER
SN - 1545-5009
IS - 12
ER -