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The UGT1A6_19_GG genotype is a breast cancer risk factor

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The UGT1A6_19_GG genotype is a breast cancer risk factor. / Justenhoven, Christina; Obazee, Ofure; Winter, Stefan; Rabstein, Sylvia; Lotz, Anne; Harth, Volker; Pesch, Beate; Brüning, Thomas; Baisch, Christian; Hartikainen, Jaana M; Mannermaa, Arto; Kosma, Veli-Matti; Kataja, Vesa; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Fasching, Peter A; Beckmann, Matthias; Ekici, Arif B; Hein, Alexander; Hall, Per; Li, Jingmei; Chang-Claude, Jenny; Flesch-Janys, Dieter; Seibold, Petra; Rudolph, Anja; Hamann, Ute; Ko, Yon-Dschun; Brauch, Hiltrud.

in: FRONT GENET, Jahrgang 4, 01.01.2013, S. 104.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Justenhoven, C, Obazee, O, Winter, S, Rabstein, S, Lotz, A, Harth, V, Pesch, B, Brüning, T, Baisch, C, Hartikainen, JM, Mannermaa, A, Kosma, V-M, Kataja, V, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Fasching, PA, Beckmann, M, Ekici, AB, Hein, A, Hall, P, Li, J, Chang-Claude, J, Flesch-Janys, D, Seibold, P, Rudolph, A, Hamann, U, Ko, Y-D & Brauch, H 2013, 'The UGT1A6_19_GG genotype is a breast cancer risk factor', FRONT GENET, Jg. 4, S. 104. https://doi.org/10.3389/fgene.2013.00104

APA

Justenhoven, C., Obazee, O., Winter, S., Rabstein, S., Lotz, A., Harth, V., Pesch, B., Brüning, T., Baisch, C., Hartikainen, J. M., Mannermaa, A., Kosma, V-M., Kataja, V., Winqvist, R., Pylkäs, K., Jukkola-Vuorinen, A., Grip, M., Fasching, P. A., Beckmann, M., ... Brauch, H. (2013). The UGT1A6_19_GG genotype is a breast cancer risk factor. FRONT GENET, 4, 104. https://doi.org/10.3389/fgene.2013.00104

Vancouver

Justenhoven C, Obazee O, Winter S, Rabstein S, Lotz A, Harth V et al. The UGT1A6_19_GG genotype is a breast cancer risk factor. FRONT GENET. 2013 Jan 1;4:104. https://doi.org/10.3389/fgene.2013.00104

Bibtex

@article{16b50a22425c41ab94e0dbbcf1cc8468,
title = "The UGT1A6_19_GG genotype is a breast cancer risk factor",
abstract = "Validation of an association between the UGT1A6_19_T>G (rs6759892) polymorphism and overall breast cancer risk. A pilot study included two population-based case-control studies from Germany (MARIE-GENICA). An independent validation study comprised four independent breast cancer case-control studies from Finland (KBCP, OBCS), Germany (BBCC), and Sweden (SASBAC). The pooled analysis included 7418 cases and 8720 controls from all six studies. Participants were of European descent. Genotyping was done by MALDI-TOF MS and statistical analysis was performed by logistic regression adjusted for age and study. The increased overall breast cancer risk for women with the UGT1A6_19_GG genotype which was observed in the pilot study was confirmed in the set of four independent study collections (OR 1.13, 95% CI 1.05-1.22; p = 0.001). The pooled study showed a similar effect (OR 1.09, 95% CI 1.04-1.14; p = 0.001). The risk effect on the basis of allele frequencies was highly significant, the pooled analysis showed an OR of 1.11 (95% CI 1.06-1.16; p = 5.8 × 10(-6)). We confirmed the association of UGT1A6_19_GG with increased overall breast cancer risk and conclude that our result from a well powered multi-stage study adds a novel candidate to the panel of validated breast cancer susceptibility loci.",
author = "Christina Justenhoven and Ofure Obazee and Stefan Winter and Sylvia Rabstein and Anne Lotz and Volker Harth and Beate Pesch and Thomas Br{\"u}ning and Christian Baisch and Hartikainen, {Jaana M} and Arto Mannermaa and Veli-Matti Kosma and Vesa Kataja and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Fasching, {Peter A} and Matthias Beckmann and Ekici, {Arif B} and Alexander Hein and Per Hall and Jingmei Li and Jenny Chang-Claude and Dieter Flesch-Janys and Petra Seibold and Anja Rudolph and Ute Hamann and Yon-Dschun Ko and Hiltrud Brauch",
year = "2013",
month = jan,
day = "1",
doi = "10.3389/fgene.2013.00104",
language = "English",
volume = "4",
pages = "104",
journal = "FRONT GENET",
issn = "1664-8021",
publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - The UGT1A6_19_GG genotype is a breast cancer risk factor

AU - Justenhoven, Christina

AU - Obazee, Ofure

AU - Winter, Stefan

AU - Rabstein, Sylvia

AU - Lotz, Anne

AU - Harth, Volker

AU - Pesch, Beate

AU - Brüning, Thomas

AU - Baisch, Christian

AU - Hartikainen, Jaana M

AU - Mannermaa, Arto

AU - Kosma, Veli-Matti

AU - Kataja, Vesa

AU - Winqvist, Robert

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Grip, Mervi

AU - Fasching, Peter A

AU - Beckmann, Matthias

AU - Ekici, Arif B

AU - Hein, Alexander

AU - Hall, Per

AU - Li, Jingmei

AU - Chang-Claude, Jenny

AU - Flesch-Janys, Dieter

AU - Seibold, Petra

AU - Rudolph, Anja

AU - Hamann, Ute

AU - Ko, Yon-Dschun

AU - Brauch, Hiltrud

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Validation of an association between the UGT1A6_19_T>G (rs6759892) polymorphism and overall breast cancer risk. A pilot study included two population-based case-control studies from Germany (MARIE-GENICA). An independent validation study comprised four independent breast cancer case-control studies from Finland (KBCP, OBCS), Germany (BBCC), and Sweden (SASBAC). The pooled analysis included 7418 cases and 8720 controls from all six studies. Participants were of European descent. Genotyping was done by MALDI-TOF MS and statistical analysis was performed by logistic regression adjusted for age and study. The increased overall breast cancer risk for women with the UGT1A6_19_GG genotype which was observed in the pilot study was confirmed in the set of four independent study collections (OR 1.13, 95% CI 1.05-1.22; p = 0.001). The pooled study showed a similar effect (OR 1.09, 95% CI 1.04-1.14; p = 0.001). The risk effect on the basis of allele frequencies was highly significant, the pooled analysis showed an OR of 1.11 (95% CI 1.06-1.16; p = 5.8 × 10(-6)). We confirmed the association of UGT1A6_19_GG with increased overall breast cancer risk and conclude that our result from a well powered multi-stage study adds a novel candidate to the panel of validated breast cancer susceptibility loci.

AB - Validation of an association between the UGT1A6_19_T>G (rs6759892) polymorphism and overall breast cancer risk. A pilot study included two population-based case-control studies from Germany (MARIE-GENICA). An independent validation study comprised four independent breast cancer case-control studies from Finland (KBCP, OBCS), Germany (BBCC), and Sweden (SASBAC). The pooled analysis included 7418 cases and 8720 controls from all six studies. Participants were of European descent. Genotyping was done by MALDI-TOF MS and statistical analysis was performed by logistic regression adjusted for age and study. The increased overall breast cancer risk for women with the UGT1A6_19_GG genotype which was observed in the pilot study was confirmed in the set of four independent study collections (OR 1.13, 95% CI 1.05-1.22; p = 0.001). The pooled study showed a similar effect (OR 1.09, 95% CI 1.04-1.14; p = 0.001). The risk effect on the basis of allele frequencies was highly significant, the pooled analysis showed an OR of 1.11 (95% CI 1.06-1.16; p = 5.8 × 10(-6)). We confirmed the association of UGT1A6_19_GG with increased overall breast cancer risk and conclude that our result from a well powered multi-stage study adds a novel candidate to the panel of validated breast cancer susceptibility loci.

U2 - 10.3389/fgene.2013.00104

DO - 10.3389/fgene.2013.00104

M3 - SCORING: Journal article

C2 - 23781229

VL - 4

SP - 104

JO - FRONT GENET

JF - FRONT GENET

SN - 1664-8021

ER -