The UGT1A6_19_GG genotype is a breast cancer risk factor
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The UGT1A6_19_GG genotype is a breast cancer risk factor. / Justenhoven, Christina; Obazee, Ofure; Winter, Stefan; Rabstein, Sylvia; Lotz, Anne; Harth, Volker; Pesch, Beate; Brüning, Thomas; Baisch, Christian; Hartikainen, Jaana M; Mannermaa, Arto; Kosma, Veli-Matti; Kataja, Vesa; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Fasching, Peter A; Beckmann, Matthias; Ekici, Arif B; Hein, Alexander; Hall, Per; Li, Jingmei; Chang-Claude, Jenny; Flesch-Janys, Dieter; Seibold, Petra; Rudolph, Anja; Hamann, Ute; Ko, Yon-Dschun; Brauch, Hiltrud.
In: FRONT GENET, Vol. 4, 01.01.2013, p. 104.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The UGT1A6_19_GG genotype is a breast cancer risk factor
AU - Justenhoven, Christina
AU - Obazee, Ofure
AU - Winter, Stefan
AU - Rabstein, Sylvia
AU - Lotz, Anne
AU - Harth, Volker
AU - Pesch, Beate
AU - Brüning, Thomas
AU - Baisch, Christian
AU - Hartikainen, Jaana M
AU - Mannermaa, Arto
AU - Kosma, Veli-Matti
AU - Kataja, Vesa
AU - Winqvist, Robert
AU - Pylkäs, Katri
AU - Jukkola-Vuorinen, Arja
AU - Grip, Mervi
AU - Fasching, Peter A
AU - Beckmann, Matthias
AU - Ekici, Arif B
AU - Hein, Alexander
AU - Hall, Per
AU - Li, Jingmei
AU - Chang-Claude, Jenny
AU - Flesch-Janys, Dieter
AU - Seibold, Petra
AU - Rudolph, Anja
AU - Hamann, Ute
AU - Ko, Yon-Dschun
AU - Brauch, Hiltrud
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Validation of an association between the UGT1A6_19_T>G (rs6759892) polymorphism and overall breast cancer risk. A pilot study included two population-based case-control studies from Germany (MARIE-GENICA). An independent validation study comprised four independent breast cancer case-control studies from Finland (KBCP, OBCS), Germany (BBCC), and Sweden (SASBAC). The pooled analysis included 7418 cases and 8720 controls from all six studies. Participants were of European descent. Genotyping was done by MALDI-TOF MS and statistical analysis was performed by logistic regression adjusted for age and study. The increased overall breast cancer risk for women with the UGT1A6_19_GG genotype which was observed in the pilot study was confirmed in the set of four independent study collections (OR 1.13, 95% CI 1.05-1.22; p = 0.001). The pooled study showed a similar effect (OR 1.09, 95% CI 1.04-1.14; p = 0.001). The risk effect on the basis of allele frequencies was highly significant, the pooled analysis showed an OR of 1.11 (95% CI 1.06-1.16; p = 5.8 × 10(-6)). We confirmed the association of UGT1A6_19_GG with increased overall breast cancer risk and conclude that our result from a well powered multi-stage study adds a novel candidate to the panel of validated breast cancer susceptibility loci.
AB - Validation of an association between the UGT1A6_19_T>G (rs6759892) polymorphism and overall breast cancer risk. A pilot study included two population-based case-control studies from Germany (MARIE-GENICA). An independent validation study comprised four independent breast cancer case-control studies from Finland (KBCP, OBCS), Germany (BBCC), and Sweden (SASBAC). The pooled analysis included 7418 cases and 8720 controls from all six studies. Participants were of European descent. Genotyping was done by MALDI-TOF MS and statistical analysis was performed by logistic regression adjusted for age and study. The increased overall breast cancer risk for women with the UGT1A6_19_GG genotype which was observed in the pilot study was confirmed in the set of four independent study collections (OR 1.13, 95% CI 1.05-1.22; p = 0.001). The pooled study showed a similar effect (OR 1.09, 95% CI 1.04-1.14; p = 0.001). The risk effect on the basis of allele frequencies was highly significant, the pooled analysis showed an OR of 1.11 (95% CI 1.06-1.16; p = 5.8 × 10(-6)). We confirmed the association of UGT1A6_19_GG with increased overall breast cancer risk and conclude that our result from a well powered multi-stage study adds a novel candidate to the panel of validated breast cancer susceptibility loci.
U2 - 10.3389/fgene.2013.00104
DO - 10.3389/fgene.2013.00104
M3 - SCORING: Journal article
C2 - 23781229
VL - 4
SP - 104
JO - FRONT GENET
JF - FRONT GENET
SN - 1664-8021
ER -