The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study

Ming Yan; Li-Yuan Xiao; Martin Gosau; Reinhard E Friedrich; Ralf Smeets; Ling-Ling Fu; Hong-Chao Feng; Simon Burg

doi:10.3389/fimmu.2023.1281292

The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study

Standard

The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study. / Yan, Ming; Xiao, Li-Yuan; Gosau, Martin ; Friedrich, Reinhard E ; Smeets, Ralf; Fu, Ling-Ling; Feng, Hong-Chao; Burg, Simon.

in: FRONT IMMUNOL, Jahrgang 14, 2023, S. 1281292.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Yan, M, Xiao, L-Y, Gosau, M , Friedrich, RE , Smeets, R, Fu, L-L, Feng, H-C & Burg, S 2023, 'The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study', FRONT IMMUNOL, Jg. 14, S. 1281292. https://doi.org/10.3389/fimmu.2023.1281292

APA

Yan, M., Xiao, L-Y., Gosau, M., Friedrich, R. E., Smeets, R., Fu, L-L., Feng, H-C., & Burg, S. (2023). The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study. FRONT IMMUNOL, 14, 1281292. https://doi.org/10.3389/fimmu.2023.1281292

Vancouver

Yan M, Xiao L-Y, Gosau M , Friedrich RE , Smeets R, Fu L-L et al. The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study. FRONT IMMUNOL. 2023;14:1281292. https://doi.org/10.3389/fimmu.2023.1281292

Bibtex

@article{a3cc0d38724647c08ac9f1ed89830d79,

title = "The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study",

abstract = "INTRODUCTION: The coronavirus disease 2019 (COVID-19) has emerged as a main global public health challenge. Additionally, herpes simplex virus type-1 (HSV-1) and type 2 (HSV-2) are widespread viruses that can cause orolabial herpes and genital herpes. Several clinical case reports have declared a possible association between the two, however, the causal relationship between them has not been clarified.METHODS: This study utilized a Mendelian randomization (MR) approach for causality assessment between COVID-19 infection and HSV infection based on the latest public health data and Genome-Wide Association Study (GWAS) data. Multiple causal estimation methods, such as IVW, weighted median, simple mode, and weighted mode, were employed to validate the causal relation between COVID-19 infection and HSV infection, with COVID-19 infection, COVID-19 hospitalization, and severe COVID-19 as exposures, and HSV1/2 infection as the outcome. A reverse MR analysis was subsequently performed.RESULTS: MR analysis exhibited that COVID-19 infection was relevant to a reduced risk of HSV1 infection (p=7.603239e-152, OR=0.5690, 95%CI=0.5455-0.5935, IVW). Regarding the effect of COVID-19 infection on HSV2, MR analysis suggested that COVID-19 infection was correlated with an augmented risk of HSV2 infection (p=6.46735e-11, OR=1.1137, 95%CI=1.0782-1.1502, IVW). The reverse MR analysis did not demonstrate a reverse causal relationship between HSV and COVID-19.DISCUSSION: Altogether, COVID-19 infection might cause a decreased risk of HSV1 infection and an elevated risk of HSV2 infection.",

keywords = "Humans, Genome-Wide Association Study, Mendelian Randomization Analysis, COVID-19, Herpesvirus 1, Human/genetics, Herpes Simplex/complications",

author = "Ming Yan and Li-Yuan Xiao and Martin Gosau and Friedrich, {Reinhard E} and Ralf Smeets and Ling-Ling Fu and Hong-Chao Feng and Simon Burg",

note = "Copyright {\textcopyright} 2023 Yan, Xiao, Gosau, Friedrich, Smeets, Fu, Feng and Burg.",

year = "2023",

doi = "10.3389/fimmu.2023.1281292",

language = "English",

volume = "14",

pages = "1281292",

journal = "FRONT IMMUNOL",

issn = "1664-3224",

publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study

AU - Yan, Ming

AU - Xiao, Li-Yuan

AU - Gosau, Martin

AU - Friedrich, Reinhard E

AU - Smeets, Ralf

AU - Fu, Ling-Ling

AU - Feng, Hong-Chao

AU - Burg, Simon

PY - 2023

Y1 - 2023

N2 - INTRODUCTION: The coronavirus disease 2019 (COVID-19) has emerged as a main global public health challenge. Additionally, herpes simplex virus type-1 (HSV-1) and type 2 (HSV-2) are widespread viruses that can cause orolabial herpes and genital herpes. Several clinical case reports have declared a possible association between the two, however, the causal relationship between them has not been clarified.METHODS: This study utilized a Mendelian randomization (MR) approach for causality assessment between COVID-19 infection and HSV infection based on the latest public health data and Genome-Wide Association Study (GWAS) data. Multiple causal estimation methods, such as IVW, weighted median, simple mode, and weighted mode, were employed to validate the causal relation between COVID-19 infection and HSV infection, with COVID-19 infection, COVID-19 hospitalization, and severe COVID-19 as exposures, and HSV1/2 infection as the outcome. A reverse MR analysis was subsequently performed.RESULTS: MR analysis exhibited that COVID-19 infection was relevant to a reduced risk of HSV1 infection (p=7.603239e-152, OR=0.5690, 95%CI=0.5455-0.5935, IVW). Regarding the effect of COVID-19 infection on HSV2, MR analysis suggested that COVID-19 infection was correlated with an augmented risk of HSV2 infection (p=6.46735e-11, OR=1.1137, 95%CI=1.0782-1.1502, IVW). The reverse MR analysis did not demonstrate a reverse causal relationship between HSV and COVID-19.DISCUSSION: Altogether, COVID-19 infection might cause a decreased risk of HSV1 infection and an elevated risk of HSV2 infection.

AB - INTRODUCTION: The coronavirus disease 2019 (COVID-19) has emerged as a main global public health challenge. Additionally, herpes simplex virus type-1 (HSV-1) and type 2 (HSV-2) are widespread viruses that can cause orolabial herpes and genital herpes. Several clinical case reports have declared a possible association between the two, however, the causal relationship between them has not been clarified.METHODS: This study utilized a Mendelian randomization (MR) approach for causality assessment between COVID-19 infection and HSV infection based on the latest public health data and Genome-Wide Association Study (GWAS) data. Multiple causal estimation methods, such as IVW, weighted median, simple mode, and weighted mode, were employed to validate the causal relation between COVID-19 infection and HSV infection, with COVID-19 infection, COVID-19 hospitalization, and severe COVID-19 as exposures, and HSV1/2 infection as the outcome. A reverse MR analysis was subsequently performed.RESULTS: MR analysis exhibited that COVID-19 infection was relevant to a reduced risk of HSV1 infection (p=7.603239e-152, OR=0.5690, 95%CI=0.5455-0.5935, IVW). Regarding the effect of COVID-19 infection on HSV2, MR analysis suggested that COVID-19 infection was correlated with an augmented risk of HSV2 infection (p=6.46735e-11, OR=1.1137, 95%CI=1.0782-1.1502, IVW). The reverse MR analysis did not demonstrate a reverse causal relationship between HSV and COVID-19.DISCUSSION: Altogether, COVID-19 infection might cause a decreased risk of HSV1 infection and an elevated risk of HSV2 infection.

KW - Humans

KW - Genome-Wide Association Study

KW - Mendelian Randomization Analysis

KW - COVID-19

KW - Herpesvirus 1, Human/genetics

KW - Herpes Simplex/complications

U2 - 10.3389/fimmu.2023.1281292

DO - 10.3389/fimmu.2023.1281292

M3 - SCORING: Journal article

C2 - 38146366

VL - 14

SP - 1281292

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

ER -