The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study
Standard
The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study. / Yan, Ming; Xiao, Li-Yuan; Gosau, Martin; Friedrich, Reinhard E; Smeets, Ralf; Fu, Ling-Ling; Feng, Hong-Chao; Burg, Simon.
In: FRONT IMMUNOL, Vol. 14, 2023, p. 1281292.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study
AU - Yan, Ming
AU - Xiao, Li-Yuan
AU - Gosau, Martin
AU - Friedrich, Reinhard E
AU - Smeets, Ralf
AU - Fu, Ling-Ling
AU - Feng, Hong-Chao
AU - Burg, Simon
N1 - Copyright © 2023 Yan, Xiao, Gosau, Friedrich, Smeets, Fu, Feng and Burg.
PY - 2023
Y1 - 2023
N2 - INTRODUCTION: The coronavirus disease 2019 (COVID-19) has emerged as a main global public health challenge. Additionally, herpes simplex virus type-1 (HSV-1) and type 2 (HSV-2) are widespread viruses that can cause orolabial herpes and genital herpes. Several clinical case reports have declared a possible association between the two, however, the causal relationship between them has not been clarified.METHODS: This study utilized a Mendelian randomization (MR) approach for causality assessment between COVID-19 infection and HSV infection based on the latest public health data and Genome-Wide Association Study (GWAS) data. Multiple causal estimation methods, such as IVW, weighted median, simple mode, and weighted mode, were employed to validate the causal relation between COVID-19 infection and HSV infection, with COVID-19 infection, COVID-19 hospitalization, and severe COVID-19 as exposures, and HSV1/2 infection as the outcome. A reverse MR analysis was subsequently performed.RESULTS: MR analysis exhibited that COVID-19 infection was relevant to a reduced risk of HSV1 infection (p=7.603239e-152, OR=0.5690, 95%CI=0.5455-0.5935, IVW). Regarding the effect of COVID-19 infection on HSV2, MR analysis suggested that COVID-19 infection was correlated with an augmented risk of HSV2 infection (p=6.46735e-11, OR=1.1137, 95%CI=1.0782-1.1502, IVW). The reverse MR analysis did not demonstrate a reverse causal relationship between HSV and COVID-19.DISCUSSION: Altogether, COVID-19 infection might cause a decreased risk of HSV1 infection and an elevated risk of HSV2 infection.
AB - INTRODUCTION: The coronavirus disease 2019 (COVID-19) has emerged as a main global public health challenge. Additionally, herpes simplex virus type-1 (HSV-1) and type 2 (HSV-2) are widespread viruses that can cause orolabial herpes and genital herpes. Several clinical case reports have declared a possible association between the two, however, the causal relationship between them has not been clarified.METHODS: This study utilized a Mendelian randomization (MR) approach for causality assessment between COVID-19 infection and HSV infection based on the latest public health data and Genome-Wide Association Study (GWAS) data. Multiple causal estimation methods, such as IVW, weighted median, simple mode, and weighted mode, were employed to validate the causal relation between COVID-19 infection and HSV infection, with COVID-19 infection, COVID-19 hospitalization, and severe COVID-19 as exposures, and HSV1/2 infection as the outcome. A reverse MR analysis was subsequently performed.RESULTS: MR analysis exhibited that COVID-19 infection was relevant to a reduced risk of HSV1 infection (p=7.603239e-152, OR=0.5690, 95%CI=0.5455-0.5935, IVW). Regarding the effect of COVID-19 infection on HSV2, MR analysis suggested that COVID-19 infection was correlated with an augmented risk of HSV2 infection (p=6.46735e-11, OR=1.1137, 95%CI=1.0782-1.1502, IVW). The reverse MR analysis did not demonstrate a reverse causal relationship between HSV and COVID-19.DISCUSSION: Altogether, COVID-19 infection might cause a decreased risk of HSV1 infection and an elevated risk of HSV2 infection.
KW - Humans
KW - Genome-Wide Association Study
KW - Mendelian Randomization Analysis
KW - COVID-19
KW - Herpesvirus 1, Human/genetics
KW - Herpes Simplex/complications
U2 - 10.3389/fimmu.2023.1281292
DO - 10.3389/fimmu.2023.1281292
M3 - SCORING: Journal article
C2 - 38146366
VL - 14
SP - 1281292
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
ER -