The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample
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The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample. / Karsak, Meliha; Malkin, Ida; Toliat, Mohammad R; Kubisch, Christian; Nürnberg, Peter; Zimmer, Andreas; Livshits, Gregory.
in: HUM GENET, Jahrgang 126, Nr. 5, 11.2009, S. 629-36.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample
AU - Karsak, Meliha
AU - Malkin, Ida
AU - Toliat, Mohammad R
AU - Kubisch, Christian
AU - Nürnberg, Peter
AU - Zimmer, Andreas
AU - Livshits, Gregory
PY - 2009/11
Y1 - 2009/11
N2 - Genetic variants within the CNR2 gene encoding the cannabinoid receptor CB2 have been shown to be associated with osteoporosis and low bone mineral density (BMD) in case-control studies. We now examined the association of polymorphisms in CNR2 with hand bone strength in an ethnically homogeneous healthy family sample of European origin (Chuvashians) living in Russia. We show that non-synonymous CNR2 SNPs are significantly associated with radiographic hand BMD and breaking bending resistance index (BBRI) by two different transmission disequilibrium tests. For both tests highly significant p values (ranging from 0.007 to 0.008 for hand BMD, and from 0.001 to 0.003 for BBRI) were also obtained with additional SNPs at the CNR2 locus. The associations remained significant after correction for multiple testing. In conclusion, in addition to the association of CNR2 polymorphisms with low BMD at selected clinically relevant skeletal sites, we now report their significant association with hand bone strength phenotypes using a family-based study design implying an even broader impact of genetic variation at the CNR2 locus on bone structure and function.
AB - Genetic variants within the CNR2 gene encoding the cannabinoid receptor CB2 have been shown to be associated with osteoporosis and low bone mineral density (BMD) in case-control studies. We now examined the association of polymorphisms in CNR2 with hand bone strength in an ethnically homogeneous healthy family sample of European origin (Chuvashians) living in Russia. We show that non-synonymous CNR2 SNPs are significantly associated with radiographic hand BMD and breaking bending resistance index (BBRI) by two different transmission disequilibrium tests. For both tests highly significant p values (ranging from 0.007 to 0.008 for hand BMD, and from 0.001 to 0.003 for BBRI) were also obtained with additional SNPs at the CNR2 locus. The associations remained significant after correction for multiple testing. In conclusion, in addition to the association of CNR2 polymorphisms with low BMD at selected clinically relevant skeletal sites, we now report their significant association with hand bone strength phenotypes using a family-based study design implying an even broader impact of genetic variation at the CNR2 locus on bone structure and function.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Bone Density/genetics
KW - Bone Remodeling/genetics
KW - Ethnicity
KW - Family
KW - Female
KW - Genetic Variation
KW - Hand Bones/anatomy & histology
KW - Hand Strength/physiology
KW - Humans
KW - Male
KW - Middle Aged
KW - Osteoporosis/genetics
KW - Pedigree
KW - Phenotype
KW - Polymorphism, Genetic
KW - Receptor, Cannabinoid, CB2/genetics
KW - Young Adult
U2 - 10.1007/s00439-009-0708-8
DO - 10.1007/s00439-009-0708-8
M3 - SCORING: Journal article
C2 - 19565271
VL - 126
SP - 629
EP - 636
JO - HUM GENET
JF - HUM GENET
SN - 0340-6717
IS - 5
ER -