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The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample

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The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample. / Karsak, Meliha; Malkin, Ida; Toliat, Mohammad R; Kubisch, Christian; Nürnberg, Peter; Zimmer, Andreas; Livshits, Gregory.

in: HUM GENET, Jahrgang 126, Nr. 5, 11.2009, S. 629-36.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Karsak, M, Malkin, I, Toliat, MR, Kubisch, C, Nürnberg, P, Zimmer, A & Livshits, G 2009, 'The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample', HUM GENET, Jg. 126, Nr. 5, S. 629-36. https://doi.org/10.1007/s00439-009-0708-8

APA

Karsak, M., Malkin, I., Toliat, M. R., Kubisch, C., Nürnberg, P., Zimmer, A., & Livshits, G. (2009). The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample. HUM GENET, 126(5), 629-36. https://doi.org/10.1007/s00439-009-0708-8

Vancouver

Karsak M, Malkin I, Toliat MR, Kubisch C, Nürnberg P, Zimmer A et al. The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample. HUM GENET. 2009 Nov;126(5):629-36. https://doi.org/10.1007/s00439-009-0708-8

Bibtex

@article{39b881ad28c34f79b6b0360ace096416,
title = "The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample",
abstract = "Genetic variants within the CNR2 gene encoding the cannabinoid receptor CB2 have been shown to be associated with osteoporosis and low bone mineral density (BMD) in case-control studies. We now examined the association of polymorphisms in CNR2 with hand bone strength in an ethnically homogeneous healthy family sample of European origin (Chuvashians) living in Russia. We show that non-synonymous CNR2 SNPs are significantly associated with radiographic hand BMD and breaking bending resistance index (BBRI) by two different transmission disequilibrium tests. For both tests highly significant p values (ranging from 0.007 to 0.008 for hand BMD, and from 0.001 to 0.003 for BBRI) were also obtained with additional SNPs at the CNR2 locus. The associations remained significant after correction for multiple testing. In conclusion, in addition to the association of CNR2 polymorphisms with low BMD at selected clinically relevant skeletal sites, we now report their significant association with hand bone strength phenotypes using a family-based study design implying an even broader impact of genetic variation at the CNR2 locus on bone structure and function.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Bone Density/genetics, Bone Remodeling/genetics, Ethnicity, Family, Female, Genetic Variation, Hand Bones/anatomy & histology, Hand Strength/physiology, Humans, Male, Middle Aged, Osteoporosis/genetics, Pedigree, Phenotype, Polymorphism, Genetic, Receptor, Cannabinoid, CB2/genetics, Young Adult",
author = "Meliha Karsak and Ida Malkin and Toliat, {Mohammad R} and Christian Kubisch and Peter N{\"u}rnberg and Andreas Zimmer and Gregory Livshits",
year = "2009",
month = nov,
doi = "10.1007/s00439-009-0708-8",
language = "English",
volume = "126",
pages = "629--36",
journal = "HUM GENET",
issn = "0340-6717",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample

AU - Karsak, Meliha

AU - Malkin, Ida

AU - Toliat, Mohammad R

AU - Kubisch, Christian

AU - Nürnberg, Peter

AU - Zimmer, Andreas

AU - Livshits, Gregory

PY - 2009/11

Y1 - 2009/11

N2 - Genetic variants within the CNR2 gene encoding the cannabinoid receptor CB2 have been shown to be associated with osteoporosis and low bone mineral density (BMD) in case-control studies. We now examined the association of polymorphisms in CNR2 with hand bone strength in an ethnically homogeneous healthy family sample of European origin (Chuvashians) living in Russia. We show that non-synonymous CNR2 SNPs are significantly associated with radiographic hand BMD and breaking bending resistance index (BBRI) by two different transmission disequilibrium tests. For both tests highly significant p values (ranging from 0.007 to 0.008 for hand BMD, and from 0.001 to 0.003 for BBRI) were also obtained with additional SNPs at the CNR2 locus. The associations remained significant after correction for multiple testing. In conclusion, in addition to the association of CNR2 polymorphisms with low BMD at selected clinically relevant skeletal sites, we now report their significant association with hand bone strength phenotypes using a family-based study design implying an even broader impact of genetic variation at the CNR2 locus on bone structure and function.

AB - Genetic variants within the CNR2 gene encoding the cannabinoid receptor CB2 have been shown to be associated with osteoporosis and low bone mineral density (BMD) in case-control studies. We now examined the association of polymorphisms in CNR2 with hand bone strength in an ethnically homogeneous healthy family sample of European origin (Chuvashians) living in Russia. We show that non-synonymous CNR2 SNPs are significantly associated with radiographic hand BMD and breaking bending resistance index (BBRI) by two different transmission disequilibrium tests. For both tests highly significant p values (ranging from 0.007 to 0.008 for hand BMD, and from 0.001 to 0.003 for BBRI) were also obtained with additional SNPs at the CNR2 locus. The associations remained significant after correction for multiple testing. In conclusion, in addition to the association of CNR2 polymorphisms with low BMD at selected clinically relevant skeletal sites, we now report their significant association with hand bone strength phenotypes using a family-based study design implying an even broader impact of genetic variation at the CNR2 locus on bone structure and function.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Bone Density/genetics

KW - Bone Remodeling/genetics

KW - Ethnicity

KW - Family

KW - Female

KW - Genetic Variation

KW - Hand Bones/anatomy & histology

KW - Hand Strength/physiology

KW - Humans

KW - Male

KW - Middle Aged

KW - Osteoporosis/genetics

KW - Pedigree

KW - Phenotype

KW - Polymorphism, Genetic

KW - Receptor, Cannabinoid, CB2/genetics

KW - Young Adult

U2 - 10.1007/s00439-009-0708-8

DO - 10.1007/s00439-009-0708-8

M3 - SCORING: Journal article

C2 - 19565271

VL - 126

SP - 629

EP - 636

JO - HUM GENET

JF - HUM GENET

SN - 0340-6717

IS - 5

ER -