Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages
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Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages. / Royzman, Dmytro; Peckert-Maier, Katrin; Stich, Lena; König, Christina; Wild, Andreas B; Tauchi, Miyuki; Ostalecki, Christian; Kiesewetter, Franklin; Seyferth, Stefan; Lee, Geoffrey; Eming, Sabine A; Fuchs, Maximilian; Kunz, Meik; Stürmer, Ewa K; Peters, Eva M J; Berking, Carola; Zinser, Elisabeth; Steinkasserer, Alexander.
in: FRONT IMMUNOL, Jahrgang 13, 1012647, 2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages
AU - Royzman, Dmytro
AU - Peckert-Maier, Katrin
AU - Stich, Lena
AU - König, Christina
AU - Wild, Andreas B
AU - Tauchi, Miyuki
AU - Ostalecki, Christian
AU - Kiesewetter, Franklin
AU - Seyferth, Stefan
AU - Lee, Geoffrey
AU - Eming, Sabine A
AU - Fuchs, Maximilian
AU - Kunz, Meik
AU - Stürmer, Ewa K
AU - Peters, Eva M J
AU - Berking, Carola
AU - Zinser, Elisabeth
AU - Steinkasserer, Alexander
N1 - Copyright © 2022 Royzman, Peckert-Maier, Stich, König, Wild, Tauchi, Ostalecki, Kiesewetter, Seyferth, Lee, Eming, Fuchs, Kunz, Stürmer, Peters, Berking, Zinser and Steinkasserer.
PY - 2022
Y1 - 2022
N2 - To facilitate the recovery process of chronic and hard-to-heal wounds novel pro-resolving treatment options are urgently needed. We investigated the pro-regenerative properties of soluble CD83 (sCD83) on cutaneous wound healing, where sCD83 accelerated wound healing not only after systemic but also after topical application, which is of high therapeutic interest. Cytokine profile analyses revealed an initial upregulation of inflammatory mediators such as TNFα and IL-1β, followed by a switch towards pro-resolving factors, including YM-1 and IL-10, both expressed by tissue repair macrophages. These cells are known to mediate resolution of inflammation and stimulate wound healing processes by secretion of growth factors such as epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), which promote vascularization as well as fibroblast and keratinocyte differentiation. In conclusion, we have found strong wound healing capacities of sCD83 beyond the previously described role in transplantation and autoimmunity. This makes sCD83 a promising candidate for the treatment of chronic- and hard-to-heal wounds.
AB - To facilitate the recovery process of chronic and hard-to-heal wounds novel pro-resolving treatment options are urgently needed. We investigated the pro-regenerative properties of soluble CD83 (sCD83) on cutaneous wound healing, where sCD83 accelerated wound healing not only after systemic but also after topical application, which is of high therapeutic interest. Cytokine profile analyses revealed an initial upregulation of inflammatory mediators such as TNFα and IL-1β, followed by a switch towards pro-resolving factors, including YM-1 and IL-10, both expressed by tissue repair macrophages. These cells are known to mediate resolution of inflammation and stimulate wound healing processes by secretion of growth factors such as epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), which promote vascularization as well as fibroblast and keratinocyte differentiation. In conclusion, we have found strong wound healing capacities of sCD83 beyond the previously described role in transplantation and autoimmunity. This makes sCD83 a promising candidate for the treatment of chronic- and hard-to-heal wounds.
KW - Epidermal Growth Factor
KW - Inflammation Mediators/metabolism
KW - Interleukin-10/metabolism
KW - Macrophages
KW - Tumor Necrosis Factor-alpha/metabolism
KW - Vascular Endothelial Growth Factor A/metabolism
KW - Wound Healing/physiology
U2 - 10.3389/fimmu.2022.1012647
DO - 10.3389/fimmu.2022.1012647
M3 - SCORING: Journal article
C2 - 36248909
VL - 13
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
M1 - 1012647
ER -