Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages

Dmytro Royzman; Katrin Peckert-Maier; Lena Stich; Christina König; Andreas B Wild; Miyuki Tauchi; Christian Ostalecki; Franklin Kiesewetter; Stefan Seyferth; Geoffrey Lee; Sabine A Eming; Maximilian Fuchs; Meik Kunz; Ewa K Stürmer; Eva M J Peters; Carola Berking; Elisabeth Zinser; Alexander Steinkasserer

doi:10.3389/fimmu.2022.1012647

Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages

Standard

Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages. / Royzman, Dmytro; Peckert-Maier, Katrin; Stich, Lena; König, Christina; Wild, Andreas B; Tauchi, Miyuki; Ostalecki, Christian; Kiesewetter, Franklin; Seyferth, Stefan; Lee, Geoffrey; Eming, Sabine A; Fuchs, Maximilian; Kunz, Meik; Stürmer, Ewa K; Peters, Eva M J; Berking, Carola; Zinser, Elisabeth; Steinkasserer, Alexander.

In: FRONT IMMUNOL, Vol. 13, 1012647, 2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Royzman, D, Peckert-Maier, K, Stich, L, König, C, Wild, AB, Tauchi, M, Ostalecki, C, Kiesewetter, F, Seyferth, S, Lee, G, Eming, SA, Fuchs, M, Kunz, M, Stürmer, EK, Peters, EMJ, Berking, C, Zinser, E & Steinkasserer, A 2022, 'Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages', FRONT IMMUNOL, vol. 13, 1012647. https://doi.org/10.3389/fimmu.2022.1012647

APA

Royzman, D., Peckert-Maier, K., Stich, L., König, C., Wild, A. B., Tauchi, M., Ostalecki, C., Kiesewetter, F., Seyferth, S., Lee, G., Eming, S. A., Fuchs, M., Kunz, M., Stürmer, E. K., Peters, E. M. J., Berking, C., Zinser, E., & Steinkasserer, A. (2022). Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages. FRONT IMMUNOL, 13, [1012647]. https://doi.org/10.3389/fimmu.2022.1012647

Vancouver

Royzman D, Peckert-Maier K, Stich L, König C, Wild AB, Tauchi M et al. Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages. FRONT IMMUNOL. 2022;13. 1012647. https://doi.org/10.3389/fimmu.2022.1012647

Bibtex

@article{b1ff150ea4144723890578d2e0557a73,

title = "Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages",

abstract = "To facilitate the recovery process of chronic and hard-to-heal wounds novel pro-resolving treatment options are urgently needed. We investigated the pro-regenerative properties of soluble CD83 (sCD83) on cutaneous wound healing, where sCD83 accelerated wound healing not only after systemic but also after topical application, which is of high therapeutic interest. Cytokine profile analyses revealed an initial upregulation of inflammatory mediators such as TNFα and IL-1β, followed by a switch towards pro-resolving factors, including YM-1 and IL-10, both expressed by tissue repair macrophages. These cells are known to mediate resolution of inflammation and stimulate wound healing processes by secretion of growth factors such as epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), which promote vascularization as well as fibroblast and keratinocyte differentiation. In conclusion, we have found strong wound healing capacities of sCD83 beyond the previously described role in transplantation and autoimmunity. This makes sCD83 a promising candidate for the treatment of chronic- and hard-to-heal wounds.",

keywords = "Epidermal Growth Factor, Inflammation Mediators/metabolism, Interleukin-10/metabolism, Macrophages, Tumor Necrosis Factor-alpha/metabolism, Vascular Endothelial Growth Factor A/metabolism, Wound Healing/physiology",

author = "Dmytro Royzman and Katrin Peckert-Maier and Lena Stich and Christina K{\"o}nig and Wild, {Andreas B} and Miyuki Tauchi and Christian Ostalecki and Franklin Kiesewetter and Stefan Seyferth and Geoffrey Lee and Eming, {Sabine A} and Maximilian Fuchs and Meik Kunz and St{\"u}rmer, {Ewa K} and Peters, {Eva M J} and Carola Berking and Elisabeth Zinser and Alexander Steinkasserer",

note = "Copyright {\textcopyright} 2022 Royzman, Peckert-Maier, Stich, K{\"o}nig, Wild, Tauchi, Ostalecki, Kiesewetter, Seyferth, Lee, Eming, Fuchs, Kunz, St{\"u}rmer, Peters, Berking, Zinser and Steinkasserer.",

year = "2022",

doi = "10.3389/fimmu.2022.1012647",

language = "English",

volume = "13",

journal = "FRONT IMMUNOL",

issn = "1664-3224",

publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages

AU - Royzman, Dmytro

AU - Peckert-Maier, Katrin

AU - Stich, Lena

AU - König, Christina

AU - Wild, Andreas B

AU - Tauchi, Miyuki

AU - Ostalecki, Christian

AU - Kiesewetter, Franklin

AU - Seyferth, Stefan

AU - Lee, Geoffrey

AU - Eming, Sabine A

AU - Fuchs, Maximilian

AU - Kunz, Meik

AU - Stürmer, Ewa K

AU - Peters, Eva M J

AU - Berking, Carola

AU - Zinser, Elisabeth

AU - Steinkasserer, Alexander

PY - 2022

Y1 - 2022

N2 - To facilitate the recovery process of chronic and hard-to-heal wounds novel pro-resolving treatment options are urgently needed. We investigated the pro-regenerative properties of soluble CD83 (sCD83) on cutaneous wound healing, where sCD83 accelerated wound healing not only after systemic but also after topical application, which is of high therapeutic interest. Cytokine profile analyses revealed an initial upregulation of inflammatory mediators such as TNFα and IL-1β, followed by a switch towards pro-resolving factors, including YM-1 and IL-10, both expressed by tissue repair macrophages. These cells are known to mediate resolution of inflammation and stimulate wound healing processes by secretion of growth factors such as epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), which promote vascularization as well as fibroblast and keratinocyte differentiation. In conclusion, we have found strong wound healing capacities of sCD83 beyond the previously described role in transplantation and autoimmunity. This makes sCD83 a promising candidate for the treatment of chronic- and hard-to-heal wounds.

AB - To facilitate the recovery process of chronic and hard-to-heal wounds novel pro-resolving treatment options are urgently needed. We investigated the pro-regenerative properties of soluble CD83 (sCD83) on cutaneous wound healing, where sCD83 accelerated wound healing not only after systemic but also after topical application, which is of high therapeutic interest. Cytokine profile analyses revealed an initial upregulation of inflammatory mediators such as TNFα and IL-1β, followed by a switch towards pro-resolving factors, including YM-1 and IL-10, both expressed by tissue repair macrophages. These cells are known to mediate resolution of inflammation and stimulate wound healing processes by secretion of growth factors such as epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), which promote vascularization as well as fibroblast and keratinocyte differentiation. In conclusion, we have found strong wound healing capacities of sCD83 beyond the previously described role in transplantation and autoimmunity. This makes sCD83 a promising candidate for the treatment of chronic- and hard-to-heal wounds.

KW - Epidermal Growth Factor

KW - Inflammation Mediators/metabolism

KW - Interleukin-10/metabolism

KW - Macrophages

KW - Tumor Necrosis Factor-alpha/metabolism

KW - Vascular Endothelial Growth Factor A/metabolism

KW - Wound Healing/physiology

U2 - 10.3389/fimmu.2022.1012647

DO - 10.3389/fimmu.2022.1012647

M3 - SCORING: Journal article

C2 - 36248909

VL - 13

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

M1 - 1012647

ER -