Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.
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Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545. / Deuse, Tobias; Hua, Xiaoqin; Taylor, Vanessa; Stubendorff, Mandy; Baluom, Muhammad; Chen, Yan; Park, Gary; Velden, Joachim; Streichert, Thomas; Reichenspurner, Hermann; Robbins, Robert C; Schrepfer, Sonja.
in: TRANSPLANTATION, Jahrgang 94, Nr. 7, 7, 2012, S. 695-702.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.
AU - Deuse, Tobias
AU - Hua, Xiaoqin
AU - Taylor, Vanessa
AU - Stubendorff, Mandy
AU - Baluom, Muhammad
AU - Chen, Yan
AU - Park, Gary
AU - Velden, Joachim
AU - Streichert, Thomas
AU - Reichenspurner, Hermann
AU - Robbins, Robert C
AU - Schrepfer, Sonja
PY - 2012
Y1 - 2012
N2 - Selective inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as a new strategy for immunosuppression. This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection.
AB - Selective inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as a new strategy for immunosuppression. This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection.
KW - Animals
KW - Male
KW - Cells, Cultured
KW - Rats
KW - Coculture Techniques
KW - Enzyme-Linked Immunosorbent Assay
KW - Phosphorylation
KW - Drug Administration Schedule
KW - Drug Therapy, Combination
KW - Drug Synergism
KW - Interferon-gamma/metabolism
KW - Rats, Inbred Lew
KW - Lymphocyte Activation/drug effects
KW - T-Lymphocytes/drug effects/immunology
KW - STAT3 Transcription Factor/metabolism
KW - Immunoglobulin M/blood
KW - Tacrolimus/pharmacology
KW - Graft Rejection/enzymology/immunology/pathology/prevention & control
KW - Graft Survival/drug effects
KW - Heart Transplantation/adverse effects/immunology
KW - Immunosuppressive Agents/administration & dosage/pharmacokinetics/pharmacology
KW - Interleukin-10/metabolism
KW - Janus Kinase 1/antagonists & inhibitors/metabolism
KW - Janus Kinase 3/antagonists & inhibitors/metabolism
KW - Lymphocyte Culture Test, Mixed
KW - Myocardium/enzymology/immunology/pathology
KW - Protein Kinase Inhibitors/administration & dosage/pharmacokinetics/pharmacology
KW - Rats, Inbred BN
KW - Animals
KW - Male
KW - Cells, Cultured
KW - Rats
KW - Coculture Techniques
KW - Enzyme-Linked Immunosorbent Assay
KW - Phosphorylation
KW - Drug Administration Schedule
KW - Drug Therapy, Combination
KW - Drug Synergism
KW - Interferon-gamma/metabolism
KW - Rats, Inbred Lew
KW - Lymphocyte Activation/drug effects
KW - T-Lymphocytes/drug effects/immunology
KW - STAT3 Transcription Factor/metabolism
KW - Immunoglobulin M/blood
KW - Tacrolimus/pharmacology
KW - Graft Rejection/enzymology/immunology/pathology/prevention & control
KW - Graft Survival/drug effects
KW - Heart Transplantation/adverse effects/immunology
KW - Immunosuppressive Agents/administration & dosage/pharmacokinetics/pharmacology
KW - Interleukin-10/metabolism
KW - Janus Kinase 1/antagonists & inhibitors/metabolism
KW - Janus Kinase 3/antagonists & inhibitors/metabolism
KW - Lymphocyte Culture Test, Mixed
KW - Myocardium/enzymology/immunology/pathology
KW - Protein Kinase Inhibitors/administration & dosage/pharmacokinetics/pharmacology
KW - Rats, Inbred BN
M3 - SCORING: Journal article
VL - 94
SP - 695
EP - 702
JO - TRANSPLANTATION
JF - TRANSPLANTATION
SN - 0041-1337
IS - 7
M1 - 7
ER -