Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.

Tobias Deuse; Xiaoqin Hua; Vanessa Taylor; Mandy Stubendorff; Muhammad Baluom; Yan Chen; Gary Park; Joachim Velden; Thomas Streichert; Hermann Reichenspurner; Robert C Robbins; Sonja Schrepfer

Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.

Standard

Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545. / Deuse, Tobias; Hua, Xiaoqin; Taylor, Vanessa; Stubendorff, Mandy; Baluom, Muhammad; Chen, Yan; Park, Gary; Velden, Joachim; Streichert, Thomas; Reichenspurner, Hermann; Robbins, Robert C; Schrepfer, Sonja.

In: TRANSPLANTATION, Vol. 94, No. 7, 7, 2012, p. 695-702.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Deuse, T, Hua, X, Taylor, V, Stubendorff, M, Baluom, M, Chen, Y, Park, G, Velden, J, Streichert, T, Reichenspurner, H, Robbins, RC & Schrepfer, S 2012, 'Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.', TRANSPLANTATION, vol. 94, no. 7, 7, pp. 695-702. <http://www.ncbi.nlm.nih.gov/pubmed/22971540?dopt=Citation>

APA

Deuse, T., Hua, X., Taylor, V., Stubendorff, M., Baluom, M., Chen, Y., Park, G., Velden, J., Streichert, T., Reichenspurner, H., Robbins, R. C., & Schrepfer, S. (2012). Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545. TRANSPLANTATION, 94(7), 695-702. [7]. http://www.ncbi.nlm.nih.gov/pubmed/22971540?dopt=Citation

Vancouver

Deuse T, Hua X, Taylor V, Stubendorff M, Baluom M, Chen Y et al. Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545. TRANSPLANTATION. 2012;94(7):695-702. 7.

Bibtex

@article{473d690242cb47ab980730dc31ed3fab,

title = "Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.",

abstract = "Selective inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as a new strategy for immunosuppression. This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection.",

keywords = "Animals, Male, Cells, Cultured, Rats, Coculture Techniques, Enzyme-Linked Immunosorbent Assay, Phosphorylation, Drug Administration Schedule, Drug Therapy, Combination, Drug Synergism, Interferon-gamma/metabolism, Rats, Inbred Lew, Lymphocyte Activation/drug effects, T-Lymphocytes/drug effects/immunology, STAT3 Transcription Factor/metabolism, Immunoglobulin M/blood, Tacrolimus/pharmacology, Graft Rejection/enzymology/immunology/pathology/*prevention & control, Graft Survival/*drug effects, Heart Transplantation/adverse effects/*immunology, Immunosuppressive Agents/administration & dosage/pharmacokinetics/*pharmacology, Interleukin-10/metabolism, Janus Kinase 1/*antagonists & inhibitors/metabolism, Janus Kinase 3/*antagonists & inhibitors/metabolism, Lymphocyte Culture Test, Mixed, Myocardium/*enzymology/immunology/pathology, Protein Kinase Inhibitors/administration & dosage/pharmacokinetics/*pharmacology, Rats, Inbred BN, Animals, Male, Cells, Cultured, Rats, Coculture Techniques, Enzyme-Linked Immunosorbent Assay, Phosphorylation, Drug Administration Schedule, Drug Therapy, Combination, Drug Synergism, Interferon-gamma/metabolism, Rats, Inbred Lew, Lymphocyte Activation/drug effects, T-Lymphocytes/drug effects/immunology, STAT3 Transcription Factor/metabolism, Immunoglobulin M/blood, Tacrolimus/pharmacology, Graft Rejection/enzymology/immunology/pathology/*prevention & control, Graft Survival/*drug effects, Heart Transplantation/adverse effects/*immunology, Immunosuppressive Agents/administration & dosage/pharmacokinetics/*pharmacology, Interleukin-10/metabolism, Janus Kinase 1/*antagonists & inhibitors/metabolism, Janus Kinase 3/*antagonists & inhibitors/metabolism, Lymphocyte Culture Test, Mixed, Myocardium/*enzymology/immunology/pathology, Protein Kinase Inhibitors/administration & dosage/pharmacokinetics/*pharmacology, Rats, Inbred BN",

author = "Tobias Deuse and Xiaoqin Hua and Vanessa Taylor and Mandy Stubendorff and Muhammad Baluom and Yan Chen and Gary Park and Joachim Velden and Thomas Streichert and Hermann Reichenspurner and Robbins, {Robert C} and Sonja Schrepfer",

year = "2012",

language = "English",

volume = "94",

pages = "695--702",

journal = "TRANSPLANTATION",

issn = "0041-1337",

publisher = "Lippincott Williams and Wilkins",

number = "7",

}

RIS

TY - JOUR

T1 - Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.

AU - Deuse, Tobias

AU - Hua, Xiaoqin

AU - Taylor, Vanessa

AU - Stubendorff, Mandy

AU - Baluom, Muhammad

AU - Chen, Yan

AU - Park, Gary

AU - Velden, Joachim

AU - Streichert, Thomas

AU - Reichenspurner, Hermann

AU - Robbins, Robert C

AU - Schrepfer, Sonja

PY - 2012

Y1 - 2012

N2 - Selective inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as a new strategy for immunosuppression. This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection.

AB - Selective inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as a new strategy for immunosuppression. This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection.

KW - Animals

KW - Male

KW - Cells, Cultured

KW - Rats

KW - Coculture Techniques

KW - Enzyme-Linked Immunosorbent Assay

KW - Phosphorylation

KW - Drug Administration Schedule

KW - Drug Therapy, Combination

KW - Drug Synergism

KW - Interferon-gamma/metabolism

KW - Rats, Inbred Lew

KW - Lymphocyte Activation/drug effects

KW - T-Lymphocytes/drug effects/immunology

KW - STAT3 Transcription Factor/metabolism

KW - Immunoglobulin M/blood

KW - Tacrolimus/pharmacology

KW - Graft Rejection/enzymology/immunology/pathology/prevention & control

KW - Graft Survival/drug effects

KW - Heart Transplantation/adverse effects/immunology

KW - Immunosuppressive Agents/administration & dosage/pharmacokinetics/pharmacology

KW - Interleukin-10/metabolism

KW - Janus Kinase 1/antagonists & inhibitors/metabolism

KW - Janus Kinase 3/antagonists & inhibitors/metabolism

KW - Lymphocyte Culture Test, Mixed

KW - Myocardium/enzymology/immunology/pathology

KW - Protein Kinase Inhibitors/administration & dosage/pharmacokinetics/pharmacology

KW - Rats, Inbred BN