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Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish

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Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. / Geudens, Ilse; Herpers, Robert; Hermans, Karlien; Segura, Inmaculada; Ruiz de Almodovar, Carmen; Bussmann, Jeroen; De Smet, Frederik; Vandevelde, Wouter; Hogan, Benjamin M; Siekmann, Arndt; Claes, Filip; Moore, John C; Pistocchi, Anna Silvia; Loges, Sonja; Mazzone, Massimiliano; Mariggi, Giovanni; Bruyère, Françoise; Cotelli, Franco; Kerjaschki, Dontscho; Noël, Agnes; Foidart, Jean-Michel; Gerhardt, Holger; Ny, Annelii; Langenberg, Tobias; Lawson, Nathan D; Duckers, Henricus J; Schulte-Merker, Stefan; Carmeliet, Peter; Dewerchin, Mieke.

in: ARTERIOSCL THROM VAS, Jahrgang 30, Nr. 9, 09.2010, S. 1695-702.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Geudens, I, Herpers, R, Hermans, K, Segura, I, Ruiz de Almodovar, C, Bussmann, J, De Smet, F, Vandevelde, W, Hogan, BM, Siekmann, A, Claes, F, Moore, JC, Pistocchi, AS, Loges, S, Mazzone, M, Mariggi, G, Bruyère, F, Cotelli, F, Kerjaschki, D, Noël, A, Foidart, J-M, Gerhardt, H, Ny, A, Langenberg, T, Lawson, ND, Duckers, HJ, Schulte-Merker, S, Carmeliet, P & Dewerchin, M 2010, 'Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish', ARTERIOSCL THROM VAS, Jg. 30, Nr. 9, S. 1695-702. https://doi.org/10.1161/ATVBAHA.110.203034

APA

Geudens, I., Herpers, R., Hermans, K., Segura, I., Ruiz de Almodovar, C., Bussmann, J., De Smet, F., Vandevelde, W., Hogan, B. M., Siekmann, A., Claes, F., Moore, J. C., Pistocchi, A. S., Loges, S., Mazzone, M., Mariggi, G., Bruyère, F., Cotelli, F., Kerjaschki, D., ... Dewerchin, M. (2010). Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. ARTERIOSCL THROM VAS, 30(9), 1695-702. https://doi.org/10.1161/ATVBAHA.110.203034

Vancouver

Geudens I, Herpers R, Hermans K, Segura I, Ruiz de Almodovar C, Bussmann J et al. Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. ARTERIOSCL THROM VAS. 2010 Sep;30(9):1695-702. https://doi.org/10.1161/ATVBAHA.110.203034

Bibtex

@article{c58cdc5a367340039627758b84461cbb,
title = "Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish",
abstract = "OBJECTIVE: To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development.METHODS AND RESULTS: In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal lymphangioblasts; instead, sprouts connecting to the intersomitic vessels were formed. At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates.CONCLUSIONS: These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network.",
keywords = "Animals, Animals, Genetically Modified, Biomarkers, COS Cells, Cell Movement, Cell Proliferation, Cercopithecus aethiops, Coculture Techniques, Embryo, Nonmammalian, Endothelial Cells, Gene Expression Regulation, Developmental, Gene Knockdown Techniques, Gene Silencing, Humans, Intracellular Signaling Peptides and Proteins, Luminescent Proteins, Lymphangiogenesis, Lymphatic System, Membrane Proteins, RNA, Messenger, Receptors, Notch, Signal Transduction, Thoracic Duct, Zebrafish, Zebrafish Proteins, Journal Article, Research Support, Non-U.S. Gov't",
author = "Ilse Geudens and Robert Herpers and Karlien Hermans and Inmaculada Segura and {Ruiz de Almodovar}, Carmen and Jeroen Bussmann and {De Smet}, Frederik and Wouter Vandevelde and Hogan, {Benjamin M} and Arndt Siekmann and Filip Claes and Moore, {John C} and Pistocchi, {Anna Silvia} and Sonja Loges and Massimiliano Mazzone and Giovanni Mariggi and Fran{\c c}oise Bruy{\`e}re and Franco Cotelli and Dontscho Kerjaschki and Agnes No{\"e}l and Jean-Michel Foidart and Holger Gerhardt and Annelii Ny and Tobias Langenberg and Lawson, {Nathan D} and Duckers, {Henricus J} and Stefan Schulte-Merker and Peter Carmeliet and Mieke Dewerchin",
year = "2010",
month = sep,
doi = "10.1161/ATVBAHA.110.203034",
language = "English",
volume = "30",
pages = "1695--702",
journal = "ARTERIOSCL THROM VAS",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

RIS

TY - JOUR

T1 - Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish

AU - Geudens, Ilse

AU - Herpers, Robert

AU - Hermans, Karlien

AU - Segura, Inmaculada

AU - Ruiz de Almodovar, Carmen

AU - Bussmann, Jeroen

AU - De Smet, Frederik

AU - Vandevelde, Wouter

AU - Hogan, Benjamin M

AU - Siekmann, Arndt

AU - Claes, Filip

AU - Moore, John C

AU - Pistocchi, Anna Silvia

AU - Loges, Sonja

AU - Mazzone, Massimiliano

AU - Mariggi, Giovanni

AU - Bruyère, Françoise

AU - Cotelli, Franco

AU - Kerjaschki, Dontscho

AU - Noël, Agnes

AU - Foidart, Jean-Michel

AU - Gerhardt, Holger

AU - Ny, Annelii

AU - Langenberg, Tobias

AU - Lawson, Nathan D

AU - Duckers, Henricus J

AU - Schulte-Merker, Stefan

AU - Carmeliet, Peter

AU - Dewerchin, Mieke

PY - 2010/9

Y1 - 2010/9

N2 - OBJECTIVE: To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development.METHODS AND RESULTS: In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal lymphangioblasts; instead, sprouts connecting to the intersomitic vessels were formed. At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates.CONCLUSIONS: These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network.

AB - OBJECTIVE: To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development.METHODS AND RESULTS: In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal lymphangioblasts; instead, sprouts connecting to the intersomitic vessels were formed. At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates.CONCLUSIONS: These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network.

KW - Animals

KW - Animals, Genetically Modified

KW - Biomarkers

KW - COS Cells

KW - Cell Movement

KW - Cell Proliferation

KW - Cercopithecus aethiops

KW - Coculture Techniques

KW - Embryo, Nonmammalian

KW - Endothelial Cells

KW - Gene Expression Regulation, Developmental

KW - Gene Knockdown Techniques

KW - Gene Silencing

KW - Humans

KW - Intracellular Signaling Peptides and Proteins

KW - Luminescent Proteins

KW - Lymphangiogenesis

KW - Lymphatic System

KW - Membrane Proteins

KW - RNA, Messenger

KW - Receptors, Notch

KW - Signal Transduction

KW - Thoracic Duct

KW - Zebrafish

KW - Zebrafish Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1161/ATVBAHA.110.203034

DO - 10.1161/ATVBAHA.110.203034

M3 - SCORING: Journal article

C2 - 20466977

VL - 30

SP - 1695

EP - 1702

JO - ARTERIOSCL THROM VAS

JF - ARTERIOSCL THROM VAS

SN - 1079-5642

IS - 9

ER -