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Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers.

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Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers. / Rubinow, D R; Post, R M; Pickar, D; Naber, Dieter; Ballenger, J C; Gold, P W; Bunney, W E.

in: PSYCHIAT RES, Jahrgang 5, Nr. 1, 1, 1981, S. 87-93.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rubinow, DR, Post, RM, Pickar, D, Naber, D, Ballenger, JC, Gold, PW & Bunney, WE 1981, 'Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers.', PSYCHIAT RES, Jg. 5, Nr. 1, 1, S. 87-93. <http://www.ncbi.nlm.nih.gov/pubmed/6269142?dopt=Citation>

APA

Rubinow, D. R., Post, R. M., Pickar, D., Naber, D., Ballenger, J. C., Gold, P. W., & Bunney, W. E. (1981). Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers. PSYCHIAT RES, 5(1), 87-93. [1]. http://www.ncbi.nlm.nih.gov/pubmed/6269142?dopt=Citation

Vancouver

Rubinow DR, Post RM, Pickar D, Naber D, Ballenger JC, Gold PW et al. Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers. PSYCHIAT RES. 1981;5(1):87-93. 1.

Bibtex

@article{cde8ff59e65a4d5b9444dba12e76cd5d,
title = "Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers.",
abstract = "We investigated the relationship between hypothalamic-pituitary-adrenal (HPA) activity, as measured by 24-hour mean urinary free cortisol (MUFC), and cerebrospinal fluid (CSF) opioid activity in patients with major affective disorder and normal volunteers. Among depressed patients, but not normal volunteers, mean 24-hour urinary cortisol values were significantly correlated with CSF opioid activity measured by radioreceptor assay, but were not significantly correlated with beta-endorphin immunoreactivity measured by radioimmunoassay. MUFC, as expected, was significantly higher in depressed patients than in normal volunteers. Mean values of CSF opioid activity and beta-endorphin immunoreactivity did not differ significantly in the two groups. The positive opioid-MUFC correlation found in the depressed group appeared to depend on patients who were cortisol hypersecretors. These data, using relatively crude measures of cortisol and opioid activity, are suggestive of a relationship between these two systems, particularly under {"}activated{"} conditions such as those observed in depression.",
author = "Rubinow, {D R} and Post, {R M} and D Pickar and Dieter Naber and Ballenger, {J C} and Gold, {P W} and Bunney, {W E}",
year = "1981",
language = "Deutsch",
volume = "5",
pages = "87--93",
journal = "PSYCHIAT RES",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers.

AU - Rubinow, D R

AU - Post, R M

AU - Pickar, D

AU - Naber, Dieter

AU - Ballenger, J C

AU - Gold, P W

AU - Bunney, W E

PY - 1981

Y1 - 1981

N2 - We investigated the relationship between hypothalamic-pituitary-adrenal (HPA) activity, as measured by 24-hour mean urinary free cortisol (MUFC), and cerebrospinal fluid (CSF) opioid activity in patients with major affective disorder and normal volunteers. Among depressed patients, but not normal volunteers, mean 24-hour urinary cortisol values were significantly correlated with CSF opioid activity measured by radioreceptor assay, but were not significantly correlated with beta-endorphin immunoreactivity measured by radioimmunoassay. MUFC, as expected, was significantly higher in depressed patients than in normal volunteers. Mean values of CSF opioid activity and beta-endorphin immunoreactivity did not differ significantly in the two groups. The positive opioid-MUFC correlation found in the depressed group appeared to depend on patients who were cortisol hypersecretors. These data, using relatively crude measures of cortisol and opioid activity, are suggestive of a relationship between these two systems, particularly under "activated" conditions such as those observed in depression.

AB - We investigated the relationship between hypothalamic-pituitary-adrenal (HPA) activity, as measured by 24-hour mean urinary free cortisol (MUFC), and cerebrospinal fluid (CSF) opioid activity in patients with major affective disorder and normal volunteers. Among depressed patients, but not normal volunteers, mean 24-hour urinary cortisol values were significantly correlated with CSF opioid activity measured by radioreceptor assay, but were not significantly correlated with beta-endorphin immunoreactivity measured by radioimmunoassay. MUFC, as expected, was significantly higher in depressed patients than in normal volunteers. Mean values of CSF opioid activity and beta-endorphin immunoreactivity did not differ significantly in the two groups. The positive opioid-MUFC correlation found in the depressed group appeared to depend on patients who were cortisol hypersecretors. These data, using relatively crude measures of cortisol and opioid activity, are suggestive of a relationship between these two systems, particularly under "activated" conditions such as those observed in depression.

M3 - SCORING: Zeitschriftenaufsatz

VL - 5

SP - 87

EP - 93

JO - PSYCHIAT RES

JF - PSYCHIAT RES

SN - 0165-1781

IS - 1

M1 - 1

ER -