Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers.
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Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers. / Rubinow, D R; Post, R M; Pickar, D; Naber, Dieter; Ballenger, J C; Gold, P W; Bunney, W E.
In: PSYCHIAT RES, Vol. 5, No. 1, 1, 1981, p. 87-93.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers.
AU - Rubinow, D R
AU - Post, R M
AU - Pickar, D
AU - Naber, Dieter
AU - Ballenger, J C
AU - Gold, P W
AU - Bunney, W E
PY - 1981
Y1 - 1981
N2 - We investigated the relationship between hypothalamic-pituitary-adrenal (HPA) activity, as measured by 24-hour mean urinary free cortisol (MUFC), and cerebrospinal fluid (CSF) opioid activity in patients with major affective disorder and normal volunteers. Among depressed patients, but not normal volunteers, mean 24-hour urinary cortisol values were significantly correlated with CSF opioid activity measured by radioreceptor assay, but were not significantly correlated with beta-endorphin immunoreactivity measured by radioimmunoassay. MUFC, as expected, was significantly higher in depressed patients than in normal volunteers. Mean values of CSF opioid activity and beta-endorphin immunoreactivity did not differ significantly in the two groups. The positive opioid-MUFC correlation found in the depressed group appeared to depend on patients who were cortisol hypersecretors. These data, using relatively crude measures of cortisol and opioid activity, are suggestive of a relationship between these two systems, particularly under "activated" conditions such as those observed in depression.
AB - We investigated the relationship between hypothalamic-pituitary-adrenal (HPA) activity, as measured by 24-hour mean urinary free cortisol (MUFC), and cerebrospinal fluid (CSF) opioid activity in patients with major affective disorder and normal volunteers. Among depressed patients, but not normal volunteers, mean 24-hour urinary cortisol values were significantly correlated with CSF opioid activity measured by radioreceptor assay, but were not significantly correlated with beta-endorphin immunoreactivity measured by radioimmunoassay. MUFC, as expected, was significantly higher in depressed patients than in normal volunteers. Mean values of CSF opioid activity and beta-endorphin immunoreactivity did not differ significantly in the two groups. The positive opioid-MUFC correlation found in the depressed group appeared to depend on patients who were cortisol hypersecretors. These data, using relatively crude measures of cortisol and opioid activity, are suggestive of a relationship between these two systems, particularly under "activated" conditions such as those observed in depression.
M3 - SCORING: Zeitschriftenaufsatz
VL - 5
SP - 87
EP - 93
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
IS - 1
M1 - 1
ER -